CAS 75607-67-9

Fosfato de fludarabina

Descripción:

Fosfato de fludarabina es un agente antineoplásico utilizado principalmente en el tratamiento de ciertos tipos de leucemia, particularmente la leucemia linfocítica crónica (LLC) y el linfoma no Hodgkin. Es un análogo de purina, específicamente un derivado de adenosina, que interfiere con la síntesis y reparación del ADN, lo que lleva a la muerte celular. El compuesto se administra típicamente por vía intravenosa y es conocido por su capacidad para penetrar eficazmente las membranas celulares debido a su forma de éster fosfato, que mejora su solubilidad. Fosfato de fludarabina presenta una vida media relativamente corta, lo que requiere un dosificación y monitoreo cuidadosos durante el tratamiento. Los efectos secundarios comunes incluyen mielosupresión, inmunosupresión y trastornos gastrointestinales. Su mecanismo de acción implica la inhibición de la ADN polimerasa y la ribonucleótido reductasa, interrumpiendo la proliferación de células malignas. Como agente quimioterapéutico, a menudo se utiliza en combinación con otros fármacos para mejorar la eficacia terapéutica. Debido a sus potentes efectos, Fosfato de fludarabina se clasifica como un fármaco peligroso, requiriendo medidas adecuadas de manejo y eliminación en entornos clínicos.

Fórmula: C₁₀H₁₃FN₅O₇P

InChI: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

Clave InChI: InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]3O)=NC(F)=N1

Sinónimos:

• 9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate
• 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-
• 9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate)
• 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
• Fludarabine phosphate
• Fludarabin Phosphate
• NSC 312887
• NSC 328002
• 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate
• 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
• 9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate
• 2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine

Fludarabine Monophosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 365.21

Ref: 3B-F0913

FLUDARABINE FOR SYSTEM SUITABILITY CRS

CAS: 75607-67-9

FLUDARABINE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001536

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 97.8%

Forma y color: White. To. Off-White

Peso molecular: 365.05366

Ref: 47-1321

FLUDARABINE PHOSPHATE CRS

CAS: 75607-67-9

FLUDARABINE PHOSPHATE CRS

Fórmula: C₁₀H₁₃FN₅O₇P

Forma y color: Added Added

Peso molecular: 365.2117

Ref: 41-Y0000419

FLUDARABINE FOR PEAK IDENTIFICATION CRS

CAS: 75607-67-9

FLUDARABINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002256

Fludarabine Phosphate

CAS: 75607-67-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₀H₁₃FN₅O₇P

Forma y color: White Crystalline Powder

Peso molecular: 365.05366

Ref: 45-1272204

{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 98%

Forma y color: Solid

Peso molecular: 365.2117

Ref: IN-DA00ICN9

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Pureza: 98%

Peso molecular: 365.21g/mol

Ref: 54-PC109175

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Pureza: ≥98%

Peso molecular: 365.21g/mol

Ref: 54-BUP15559

Fludarabine Phosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Forma y color: White To Off-White Solid

Peso molecular: 365.22

Ref: 4Z-F-588

Fludarabine phosphate, USP

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: ≤ 0.1%

Forma y color: White powder

Peso molecular: 365.21

Ref: 7W-GP3476

Fludarabine Phosphate

CAS: 75607-67-9

Forma y color: Neat

Ref: 86-MM3428.00

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate (NSC 312887 Phosphate) is a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine with antineoplastic activity.

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 99.25% - 99.78%

Forma y color: Solid

Peso molecular: 365.21

Ref: TM-T6501

Fludarabine phosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: ≥ 98.0%

Forma y color: White to almost white powder

Peso molecular: 365.21

Ref: 7W-GP0418

Fludarabine phosphate

CAS: 75607-67-9

Pureza: 98%

Peso molecular: 365.21

Ref: 10-F792862

Fludarabine Phosphate

Producto controlado

CAS: 75607-67-9

Applications 4-Desfluoro-4-(1,2,4-triazol-1-yl)phenyl Fluconazole is an impurity in the synthesis of Fluconazole (F421000), used as an antifungal.
References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985);

Fórmula: C₁₀H₁₃FN₅O₇P

Forma y color: White To Off-White

Peso molecular: 365.21

Ref: TR-F425005

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate is an antileukemic drug that inhibits DNA polymerase α and β, as well as other enzymes in the nucleotide synthesis pathway. It is used to treat patients with chronic myelogenous leukemia (CML) who have developed resistance to other treatments. Fludarabine phosphate has been shown to induce a cytotoxic effect against tumor cells by binding to ATP-binding cassette transporter proteins on the cell membrane and inhibiting intracellular targets such as DNA, RNA, and protein synthesis. Fludarabine phosphate has also been shown to inhibit the growth of tumor cells through synergistic interactions with other anticancer drugs such as hydroxyurea or busulfan, which may be due to its ability to inhibit enzyme activities such as erythrocyte alkaline phosphatase.

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 365.21 g/mol

Ref: 3D-NF01485