CAS 75706-12-6
:Leflunomida
Descripción:
Leflunomida es un fármaco inmunomodulador utilizado principalmente en el tratamiento de la artritis reumatoide y la artritis psoriásica. Funciona como un profármaco, lo que significa que se metaboliza en el cuerpo a su forma activa, A77 1726, que inhibe la enzima dihidroorotato deshidrogenasa. Esta inhibición interrumpe la síntesis de novo de pirimidinas, lo que lleva a una reducción en la proliferación de linfocitos y a la modulación de las respuestas inmunitarias. Leflunomida se caracteriza por su vida media relativamente larga, lo que permite una dosificación una vez al día. Se administra típicamente por vía oral y es conocido por sus posibles efectos secundarios, que pueden incluir toxicidad hepática, trastornos gastrointestinales y efectos en los recuentos de células sanguíneas. El fármaco está contraindicado en el embarazo debido a sus efectos teratogénicos. Además, Leflunomida se utiliza a menudo en combinación con otros fármacos antirreumáticos modificadores de la enfermedad (DMARDs) para mejorar la eficacia terapéutica. Su estructura química incluye un derivado de pirimidina, que contribuye a su mecanismo de acción y propiedades farmacológicas.
Fórmula:C12H9F3N2O2
InChI:InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
Clave InChI:InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
SMILES:C(NC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(C)ON=C2
Sinónimos:- 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-
- 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
- 5-Methylisoxazole-4-Carboxylic Acid (4-Trifluoromethyl)Anilide
- 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide
- 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide
- Alpha,Alpha,Alpha-Trifluoro-5-Methyl-4-Isoxazolecarboxy-P-Toluidide
- Arava
- Avara
- Cleft
- Hwa 486
- Hwa486
- Leflunomida
- Leflunomidum
- Lefumide
- N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
- Repso
- Rs-34821
- SU 101 (pharmaceutical)
- Su 101
- alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine
- Ver más sinónimos
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Encontrado 18 productos.
Leflunomide
CAS:Fórmula:C12H9F3N2O2Pureza:>98.0%(HPLC)(N)Forma y color:White to Almost white powder to crystalPeso molecular:270.21Leflunomide
CAS:<p>An immunosuppressive agent. Inhibits T and B cell proliferation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU referenc</p>Fórmula:C12H9F3N2O2Peso molecular:270.21LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS
CAS:<p>LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS</p>Fórmula:C12H9F3N2O2Forma y color:White. Powder.Peso molecular:270.2073LEFLUNOMIDE CRS
CAS:<p>LEFLUNOMIDE CRS</p>Fórmula:C12H9F3N2O2Forma y color:White. Powder.Peso molecular:270.2073Leflunomide
CAS:LeflunomideFórmula:C12H9F3N2O2Pureza:99.9%Forma y color:Off-WhitePeso molecular:270.06161Leflunomide
CAS:<p>Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi</p>Fórmula:C12H9F3N2O2Forma y color:White PowderPeso molecular:270.06161Leflunomide
CAS:<p>Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.</p>Fórmula:C12H9F3N2O2Pureza:99.52% - 99.96%Forma y color:Off White Crystalline SolidPeso molecular:270.21Leflunomide
CAS:Fórmula:C12H9F3N2O2Pureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:270.21Leflunomide
CAS:Producto controlado<p>Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),<br></p>Fórmula:C12H9F3N2O2Forma y color:NeatPeso molecular:270.21Leflunomide - Bio-X ™
CAS:Producto controlado<p>Leflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.</p>Fórmula:C12H9F3N2O2Pureza:Min. 95%Forma y color:PowderPeso molecular:270.21 g/molLeflunomide
CAS:Producto controlado<p>Src kinase inhibitor; dihydroorotate dehydrogenase inhibitor; aryl hydrocarbon receptor agonist</p>Fórmula:C12H9F3N2O2Pureza:Min. 95%Forma y color:White PowderPeso molecular:270.21 g/mol5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
CAS:Fórmula:C12H9F3N2O2Pureza:97.0%Forma y color:No data available.Peso molecular:270.211
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