CAS 75706-12-6

Leflunomida

Descripción:

Leflunomida es un fármaco inmunomodulador utilizado principalmente en el tratamiento de la artritis reumatoide y la artritis psoriásica. Funciona como un profármaco, lo que significa que se metaboliza en el cuerpo a su forma activa, A77 1726, que inhibe la enzima dihidroorotato deshidrogenasa. Esta inhibición interrumpe la síntesis de novo de pirimidinas, lo que lleva a una reducción en la proliferación de linfocitos y a la modulación de las respuestas inmunitarias. Leflunomida se caracteriza por su vida media relativamente larga, lo que permite una dosificación una vez al día. Se administra típicamente por vía oral y es conocido por sus posibles efectos secundarios, que pueden incluir toxicidad hepática, trastornos gastrointestinales y efectos en los recuentos de células sanguíneas. El fármaco está contraindicado en el embarazo debido a sus efectos teratogénicos. Además, Leflunomida se utiliza a menudo en combinación con otros fármacos antirreumáticos modificadores de la enfermedad (DMARDs) para mejorar la eficacia terapéutica. Su estructura química incluye un derivado de pirimidina, que contribuye a su mecanismo de acción y propiedades farmacológicas.

Fórmula: C₁₂H₉F₃N₂O₂

InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

Clave InChI: InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N

SMILES: C(NC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(C)ON=C2

Sinónimos:

• 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-
• 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
• 5-Methylisoxazole-4-Carboxylic Acid (4-Trifluoromethyl)Anilide
• 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide
• 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide
• Alpha,Alpha,Alpha-Trifluoro-5-Methyl-4-Isoxazolecarboxy-P-Toluidide
• Arava
• Avara
• Cleft
• Hwa 486
• Hwa486
• Leflunomida
• Leflunomidum
• Lefumide
• N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
• Repso
• Rs-34821
• SU 101 (pharmaceutical)
• Su 101
• alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine

Leflunomide

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: >98.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 270.21

Ref: 3B-L0250

Leflunomide

CAS: 75706-12-6

An immunosuppressive agent. Inhibits T and B cell proliferation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU referenc

Fórmula: C₁₂H₉F₃N₂O₂

Peso molecular: 270.21

Ref: 02-J65917

LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS

CAS: 75706-12-6

LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: White. Powder.

Peso molecular: 270.2073

Ref: 41-Y0000674

LEFLUNOMIDE CRS

CAS: 75706-12-6

LEFLUNOMIDE CRS

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: White. Powder.

Peso molecular: 270.2073

Ref: 41-Y0000654

Leflunomide

CAS: 75706-12-6

Leflunomide

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: 99.9%

Forma y color: Off-White

Peso molecular: 270.06161

Ref: 47-1233

Leflunomide

CAS: 75706-12-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: White Powder

Peso molecular: 270.06161

Ref: 45-1356960

Leflunomide

CAS: 75706-12-6

Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: 99.52% - 99.96%

Forma y color: Off White Crystalline Solid

Peso molecular: 270.21

Ref: TM-T1159

Leflunomide

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: White To Off-White Solid

Peso molecular: 270.21

Ref: 4Z-L-041

Leflunomide

CAS: 75706-12-6

Leflunomide

Pureza: ≥98%

Peso molecular: 270.21g/mol

Ref: 54-BUP15817

Leflunomide

CAS: 75706-12-6

Leflunomide

Pureza: 99%

Peso molecular: 270.21g/mol

Ref: 54-PC109034

Leflunomide

Producto controlado

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: Neat

Peso molecular: 270.21

Ref: 86-MM0859.00

Leflunomide

Producto controlado

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: Neat

Peso molecular: 270.21

Ref: 04-C14606000

Leflunomide

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 270.21

Ref: 7W-GP6125

Teriflunomide Impurity 12

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Peso molecular: 270.21

Ref: ST-EA-CP-T19003

Leflunomide

Producto controlado

CAS: 75706-12-6

Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

Fórmula: C₁₂H₉F₃N₂O₂

Forma y color: Neat

Peso molecular: 270.21

Ref: TR-L322750

Leflunomide - Bio-X ™

Producto controlado

CAS: 75706-12-6

Leflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 270.21 g/mol

Ref: 3D-BM164612

Leflunomide

Producto controlado

CAS: 75706-12-6

Src kinase inhibitor; dihydroorotate dehydrogenase inhibitor; aryl hydrocarbon receptor agonist

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 270.21 g/mol

Ref: 3D-FL16204

5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

CAS: 75706-12-6

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: 97.0%

Forma y color: No data available.

Peso molecular: 270.211

Ref: 10-F358076