CAS 76-66-4

Rincofilina

Descripción:

Rincofilina es un alcaloide derivado principalmente de la especie de planta Uncaria rhynchophylla, comúnmente conocida como uña de gato. Se caracteriza por su compleja estructura química, que incluye un marco tetracíclico. Rincofilina exhibe una variedad de propiedades farmacológicas, incluyendo efectos neuroprotectores, antiinflamatorios y analgésicos. Se ha estudiado por sus posibles aplicaciones terapéuticas en condiciones como la hipertensión y enfermedades neurodegenerativas. El compuesto interactúa con varios sistemas de neurotransmisores, influyendo particularmente en el sistema nervioso central. Además, Rincofilina ha mostrado promesas en la modulación de canales de calcio y puede poseer propiedades antioxidantes. Su solubilidad es generalmente baja en agua, pero puede variar en disolventes orgánicos. Al igual que muchos alcaloides, el perfil de seguridad y los posibles efectos secundarios de Rincofilina requieren una investigación adicional, particularmente en el uso a largo plazo o en dosis altas. En general, Rincofilina representa un área significativa de interés en la química de productos naturales y farmacología, lo que justifica una investigación adicional para elucidar completamente sus mecanismos de acción y potencial terapéutico.

Fórmula: C₂₂H₂₈N₂O₄

InChI: InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

Clave InChI: InChIKey=DAXYUDFNWXHGBE-KAXDATADSA-N

SMILES: O=C1[C@@]2([C@]3(N(CC2)C[C@H](CC)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4

Sinónimos:

• Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7β,16E,20α)-
• Mitrinermin
• Mitrinermine
• NSC 21731
• Rhyncholphylline
• Rhynchophyllin
• Rhyncophylline
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1′R,6′R,7′S,8′aS)-
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1′R-[1′α,6′β,7′α(E),8′aβ]]-
• methyl (16Z)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16Z,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (7beta,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• Rhynchophylline
• UNCARINE D(P)
• (7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
• Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)-
• 16e,20-alpha)-(7-bet

Rhynchophylline

CAS: 76-66-4

Fórmula: C₂₂H₂₈N₂O₄

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 384.48

Ref: 3B-R0105

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Pureza: ≥98%

Peso molecular: 384.47g/mol

Ref: 54-BUP02284

Rhynchophylline

CAS: 76-66-4

Fórmula: C₂₂H₂₈N₂O₄

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 384.47

Ref: 7W-GP0939

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Pureza: 98%

Peso molecular: 384.47g/mol

Ref: 54-OR1023242

Rhynchophylline

CAS: 76-66-4

Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function.

Fórmula: C₂₂H₂₈N₂O₄

Pureza: 95%~99%

Peso molecular: 384.476

Ref: BP-BP1216

Rhynchophylline

CAS: 76-66-4

Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.

Fórmula: C₂₂H₂₈N₂O₄

Pureza: 99.44% - 99.98%

Forma y color: Red Brown Or White Fine Powder

Peso molecular: 384.47

Ref: TM-T6S0659

Rhynchophylline

CAS: 76-66-4

Fórmula: C₂₂H₂₈N₂O₄

Peso molecular: 384.48

Ref: 4Z-R-173001

Rhynchophylline

CAS: 76-66-4

Natural alkaloid

Fórmula: C₂₂H₂₈N₂O₄

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 384.48

Ref: 5G-80526

Rhynchophylline

CAS: 76-66-4

Applications Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.
References Fu, A K.Y., et. al.: P. Natl. Acad. Sci. USA., 111, 9959 (2014)

Fórmula: C₂₂H₂₈N₂O₄

Forma y color: Neat

Peso molecular: 384.47

Ref: TR-R414180

Rhynchophylline

CAS: 76-66-4

Rhynchophylline is an indole alkaloid, which is naturally sourced from the Uncaria genus, specifically from Uncaria rhynchophylla. This alkaloid exhibits its mode of action primarily through non-competitive inhibition of NMDA receptors and L-type calcium channels. It has been observed to modulate both glutamatergic and serotonergic signaling pathways, which underscores its potential neurological impacts.

Fórmula: C₂₂H₂₈N₂O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 384.47 g/mol

Ref: 3D-FR42770

Rhynchophylline - Bio-X ™

CAS: 76-66-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₂H₂₈N₂O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 384.47 g/mol

Ref: 3D-BR300119