CAS 76410-58-7

L-p-Boronofenilalanina

Descripción:

L-p-Boronofenilalanina (BPA) es un derivado de aminoácido que contiene boro de la fenilalanina, caracterizado por la presencia de un átomo de boro unido al grupo fenilo. Se reconoce principalmente por sus posibles aplicaciones en la terapia de captura de neutrones de boro (BNCT), un tratamiento contra el cáncer dirigido que explota las propiedades únicas del boro para destruir selectivamente las células cancerosas cuando se expone a la radiación de neutrones. BPA es típicamente un sólido cristalino blanco a blanco amarillento, soluble en agua y varios disolventes orgánicos, lo que facilita su uso en sistemas biológicos. El compuesto exhibe propiedades típicas de los aminoácidos, incluida la capacidad de participar en la formación de enlaces peptídicos e interacciones con receptores biológicos. Su funcionalidad única de boro permite interacciones específicas en entornos biológicos, lo que lo convierte en un tema de interés en química medicinal e investigación del cáncer. Además, la estabilidad y reactividad de L-p-Boronofenilalanina pueden verse influenciadas por el pH y la temperatura, que son factores importantes a considerar en aplicaciones terapéuticas.

Fórmula: C₉H₁₂BNO₄

InChI: InChI=1/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1

Clave InChI: InChIKey=NFIVJOSXJDORSP-QMMMGPOBSA-N

SMILES: C([C@@H](C(O)=O)N)C1=CC=C(B(O)O)C=C1

Sinónimos:

• 10B-Bpa
• 4-(Dihydroxyboranyl)Phenylalanine
• 4-(Dihydroxyboryl)-<span class="text-smallcaps">L</span>-phenylalanine
• 4-(dihydroxyboranyl)-L-phenylalanine
• 4-Borono-<span class="text-smallcaps">L</span>-phenylalanine
• 4-Boronophenylalanine
• 4-Dihydroxyborylphenylalanine
• <span class="text-smallcaps">L</span>-BPA
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-borono-
• <span class="text-smallcaps">L</span>-p-Boronophenylalanine
• L-Phenylalanine, 4-borono-
• para-Borono-L-phenylalanine
• para-Boronophenylalanine
• 4-(Dihydroxyboryl)-L-phenylalanine
• 4-Borono-L-phenylalanine
• L-BPA
• L-p-Boronophenylalanine
• 4-BORONO-L-PHENYLALANINE B10 ENRICHED
• L-4-PHENYLALANINEBORONIC ACID
• (S)-(4-BORONIC ACID)-PHENYLALANINE
• 4-L-BPA
• 4-Dihydroxyboryl-L-phenylalanine, L-BPA
• L-PHE[B(OH)2]

4-Borono-L-phenylalanine (contains varying amounts of Anhydride)

CAS: 76410-58-7

Fórmula: C₉H₁₂BNO₄

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 209.01

Ref: 3B-B6405

(S)-2-Amino-3-(4-boronophenyl)propanoic acid

CAS: 76410-58-7

Fórmula: C₉H₁₂BNO₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 209.0069

Ref: IN-DA005Y45

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine

Pureza: ≥95%

Peso molecular: 209.01g/mol

Ref: 54-BUP17237

4-Borono-L-phenylalanine

CAS: 76410-58-7

Peso molecular: 209.01

Ref: 7W-GM4799

L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid

CAS: 76410-58-7

L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid

Fórmula: C₉H₁₂BNO₄

Pureza: ≥95%

Forma y color: white solid

Peso molecular: 209.01g/mol

Ref: 54-OR60018

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine: antitumor agent for melanoma, glioblastoma trials in boron neutron capture therapy.

Fórmula: C₉H₁₂BNO₄

Pureza: 96.45%

Forma y color: Solid

Peso molecular: 209.01

Ref: TM-T77706

4-Borono-L-phenylalanine

Producto controlado

CAS: 76410-58-7

Applications 4-Borono-L-phenylalanine is an unnatural derivative of L-Phenylalanine (P319415). a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. 4-Borono-L-phenylalanine is also being used as a mediator in sequential boron neutron capture therapy, a new method of treating oral cancer.
References Birkmayer, W., et al.: J. Neural Transm., 59, 81 (1984); Johnson, D.,et al.: Nat. Chem. Biol., 7, 779 (2011); Kankaanranta, L., et al.: Int. J. Radiat. Oncol., 80, 369 (2011); Molinari, A., et al.: Radiat. Res., 175, 463 (2011)

Fórmula: C₉H₁₂BNO₄

Forma y color: Neat

Peso molecular: 209.01

Ref: TR-B675600

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine is a boron-containing compound that has been used to study the biological effects of radiation. 4-Borono-L-phenylalanine is an analytical tool for measuring neutron scattering and other physical properties. It has also been used as a biochemical probe in studies of DNA duplexes. 4-Borono-L-phenylalanine is toxic to cells, inhibiting protein synthesis, and it can induce apoptosis in tumor cells. In experimental models, 4-borono-L phenylalanine can be administered orally or intravenously and has shown acute toxicity in animals at doses of up to 1000 mg/kg body weight.

Fórmula: C₉H₁₂BNO₄

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 209.01 g/mol

Ref: 3D-FB139059

L-4-Phenylalanineboronic acid

CAS: 76410-58-7

Fórmula: C₉H₁₂BNO₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 209.01

Ref: 10-F011054