CAS 76712-82-8

des-gly10,(D-his(bzl)6)-lh-rh*etilamida

Descripción:

des-gly10,(D-his(bzl)6)-lh-rh*etilamida, con el número CAS 76712-82-8, es un análogo de péptido sintético derivado de la hormona que ocurre naturalmente, la hormona liberadora de luteinizante (LHRH). Este compuesto se caracteriza por sus modificaciones estructurales, que incluyen la eliminación del residuo de glicina en la posición 10 y la incorporación de un residuo de D-histidina con un grupo bencilo en la posición 6. Estas modificaciones mejoran su estabilidad y bioactividad en comparación con la LHRH nativa. El compuesto generalmente exhibe alta afinidad por los receptores de LHRH, lo que lo hace de interés en la investigación relacionada con la biología reproductiva y aplicaciones terapéuticas potenciales en trastornos relacionados con hormonas. Su estructura única permite una acción prolongada en sistemas biológicos, lo que puede ser beneficioso en entornos clínicos. Como péptido, es generalmente soluble en soluciones acuosas y puede requerir condiciones específicas para su almacenamiento y manejo para mantener su integridad. En general, des-gly10,(D-his(bzl)6)-lh-rh*etilamida representa un avance significativo en el diseño de péptidos para terapias hormonales dirigidas.

Fórmula: C₆₆H₈₆N₁₈O₁₂

InChI: InChI=1/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71);1H3,(H,3,4)/t47-,48-,49-,50-,51-,52-,53+,54-,55-;/m0./s1

Sinónimos:

• Histrelin
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
• ^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
• 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
• (n-ethyl-l-prolinamide)-10-deglycinamide-
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
• Supprelin
• Histreline Acetate
• histrelin acetate
• 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
• 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
• RWJ-17070
• DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
• ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
• orf17070
• (HIS(BZL)6)-HISTRELIN
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
• Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
• PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

Histrelin

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Peso molecular: 1323.50

Ref: 7W-GP6870

Histrelin

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Peso molecular: 1323.53

Ref: 4Z-PH-047001

Histrelin Acetate

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 1323.5

Ref: BP-BPPG040

Histrelin Acetic Acid Salt

CAS: 76712-82-8

Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.
References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);

Fórmula: C₆₆H₈₆N₁₈O₁₂•xCH₃COOH

Forma y color: Neat

Peso molecular: 1323.506005

Ref: TR-H456310

Histrelin Acetate

CAS: 76712-82-8

Histrelin acetate is a synthetic analog of the natural hormone histrelin. It has been used clinically to treat prostate cancer, androgenetic alopecia, and other conditions. Histrelin acetate binds to receptors in the hypothalamus and pituitary gland that are responsible for regulating the production of sex hormones. This drug is administered by injection into the pubic area or under the skin as an implant. Histrelin acetate's effectiveness is related to its suppression of gonadotropins, which results in decreased testosterone levels. Histrelin acetate also decreases testosterone production by inhibiting gonadotropin-releasing hormone from stimulating the anterior pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The long-term efficacy of this drug has been demonstrated in clinical studies lasting up to two years with no significant adverse effects on bone mineral density or sexual function.

Pureza: Min. 95%

Ref: 3D-FH138112