CAS 767340-03-4

(2Z)-3-Amino-1-[5,6-dihidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-ona

Descripción:

(2Z)-3-Amino-1-[5,6-dihidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-ona es un compuesto orgánico complejo caracterizado por sus características estructurales únicas, que incluyen un núcleo de triazolo-pirazina y múltiples sustituyentes trifluorometilo y trifluorofenilo. Este compuesto exhibe una actividad biológica significativa, a menudo investigada por su potencial como agente farmacéutico. La presencia del grupo amino sugiere que puede participar en enlaces de hidrógeno, influyendo en su solubilidad y reactividad. Los grupos trifluorometilo mejoran la lipofilia y pueden contribuir a las propiedades farmacocinéticas del compuesto. Además, el sistema conjugado formado por la parte de butenona puede proporcionar reactividad en diversas transformaciones químicas. Su estructura molecular indica interacciones potenciales con objetivos biológicos, convirtiéndolo en un tema de interés en la química medicinal. En general, este compuesto ejemplifica la intrincada relación entre la estructura molecular y la actividad biológica, destacando la importancia de los compuestos fluorados en el diseño de fármacos.

Fórmula: C₁₆H₁₃F₆N₅O

InChI: InChI=1/C16H13F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4-6H,1-3,7,23H2/b9-5-

Clave InChI: InChIKey=RLSFDUAUKXKPCZ-UITAMQMPSA-N

SMILES: C(F)(F)(F)C=1N2C(CN(C(/C=C(/CC3=C(F)C=C(F)C(F)=C3)\N)=O)CC2)=NN1

Sinónimos:

• (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• (Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(2Z)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
• 2-Buten-1-one, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)-
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• （2Z）-2-amine-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro][1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en (2-4)
• (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]

Sitagliptin Enamine ((Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one)

CAS: 767340-03-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₆H₁₃F₆N₅O

Forma y color: Off-White Solid

Peso molecular: 405.10243

Ref: 45-1A02650

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Pureza: 98%

Forma y color: Solid

Peso molecular: 405.2977

Ref: IN-DA0036IO

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

Pureza: 95%

Peso molecular: 405.3g/mol

Ref: 54-PC1004071

Sitagliptin Impurity 34

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Forma y color: White To Off-White Solid

Peso molecular: 405.30

Ref: 4Z-S-2011

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Forma y color: Neat

Ref: 86-MM3378.20

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifl

Producto controlado

CAS: 767340-03-4

Applications Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.
References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)

Fórmula: C₁₆H₁₃F₆N₅O

Forma y color: White

Peso molecular: 405.30

Ref: TR-O865000

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a drug that has been studied in hemodialysis patients and found to reduce the mutation rate. It is also thought to be beneficial for hematocrit levels and x-ray parameters. The mechanism of action of this drug is not yet fully understood. Low doses are thought to have a protective effect on germ cells, whereas high doses are thought to have an adverse effect on them. Iron supplementation may help with the adverse effects of high doses.

Fórmula: C₁₆H₁₃F₆N₅O

Pureza: Min. 95%

Forma y color: White Off-White Powder

Peso molecular: 405.3 g/mol

Ref: 3D-FO155533

Sitagliptin Enamine Impurity

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Peso molecular: 405.30

Ref: ST-EA-CP-S3016

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66986 and the CAS number is 767340-03-4.

Fórmula: C₁₆H₁₃F₆N₅O

Forma y color: Solid

Peso molecular: 405.304

Ref: TM-T66986