CAS 76801-85-9

9-Deoxo-9a-aza-9a-homoeritromicina A

Descripción:

9-Deoxo-9a-aza-9a-homoeritromicina A, con el número CAS 76801-85-9, es un derivado semisintético de la eritromicina, un antibiótico macrólido. Este compuesto se caracteriza por la presencia de un átomo de nitrógeno en la posición 9a, lo que altera sus propiedades farmacológicas en comparación con su compuesto original. Exhibe actividad antibacteriana principalmente contra bacterias Gram-positivas y algunas cepas Gram-negativas, lo que lo hace útil en el tratamiento de diversas infecciones bacterianas. Las modificaciones estructurales mejoran su estabilidad y biodisponibilidad, permitiendo una mayor eficacia. Al igual que otros macrólidos, funciona inhibiendo la síntesis de proteínas bacterianas mediante la unión a la subunidad ribosomal 50S. Además, puede exhibir un espectro de actividad más amplio y una menor susceptibilidad a ciertos mecanismos de resistencia bacteriana. La solubilidad, estabilidad y propiedades farmacocinéticas del compuesto están influenciadas por su estructura única, lo que puede afectar sus aplicaciones terapéuticas y regímenes de dosificación. En general, 9-Deoxo-9a-aza-9a-homoeritromicina A representa un desarrollo importante en el campo de la investigación y tratamiento de antibióticos.

Fórmula: C₃₇H₇₀N₂O₁₂

InChI: InChI=1S/C37H70N2O12/c1-14-26-37(10,45)30(41)23(6)38-18-19(2)16-35(8,44)32(51-34-28(40)25(39(11)12)15-20(3)47-34)21(4)29(22(5)33(43)49-26)50-27-17-36(9,46-13)31(42)24(7)48-27/h19-32,34,38,40-42,44-45H,14-18H2,1-13H3/t19-,20-,21+,22-,23-,24+,25+,26-,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

Clave InChI: InChIKey=HRKNNHYKWGYTEN-HOQMJRDDSA-N

SMILES: O([C@H]1[C@H](C)[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)[C@H]3C[C@](OC)(C)[C@@H](O)[C@H](C)O3

Sinónimos:

• (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-
• 2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methylhexopyranoside
• 9-Deoxo-9a-aza-9a-homoerythromycin A
• Aza-erythromycin
• Azaerythromycin A
• Azahomoerythromycin
• Desmethyl Azithromycin
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
• (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Azaerythromycin A (9-Deoxo-9a-aza-9a-homoerythromycin A)

CAS: 76801-85-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₃₇H₇₀N₂O₁₂

Forma y color: White Powder

Peso molecular: 734.49288

Ref: 45-1045600

9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: 95%

Forma y color: Solid

Peso molecular: 734.9579

Ref: IN-DA005I8G

Azathramycin

CAS: 76801-85-9

Azathramycin

Pureza: 97%

Peso molecular: 734.96g/mol

Ref: 54-OR1028380

Azathramycin

CAS: 76801-85-9

Azathramycin

Pureza: ≥98%

Peso molecular: 734.96g/mol

Ref: 54-BUP15770

Azithromycin EP Impurity A (Azathramycin, Desmethyl Azithromycin)

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Forma y color: White To Off-White Solid

Peso molecular: 734.97

Ref: 4Z-A-2620

6-Demethylazithromycin (Azaerythromycin A)

Producto controlado

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Forma y color: Neat

Peso molecular: 734.96

Ref: 86-MM1075.01

Azathramycin

CAS: 76801-85-9

Azathramycin (Desmethyl Azithromycin) is an antibiotic derived from erythromycin, binding to the 50S subunit of the bacterial ribosome, and thus inhibits

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: 99.71%

Forma y color: White To Grayish Solid Powder

Peso molecular: 734.96

Ref: TM-T3265

Azithromycin EP Impurity A

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Peso molecular: 734.96

Ref: ST-EA-CP-A37001

9-Deoxo-9a-aza-9a-homo Erythromycin A (Desmethyl Azithromycin)

Producto controlado

CAS: 76801-85-9

Impurity Azithromycin EP Impurity A
Applications 9-Deoxo-9a-aza-9a-homo Erythromycin A (Azithromycin EP Impurity A) is a novel intermediate of Azithromycin that acts as antibiotic.
References Krajacic, M.B., et al.: J. Antibiot., 58, 380 (2005),

Fórmula: C₃₇H₇₀N₂O₁₂

Forma y color: Neat

Peso molecular: 734.96

Ref: TR-D231500

9-Deoxo-9a-aza-9a-homo erythromycin A

CAS: 76801-85-9

9-Deoxo-9a-aza-9a-homo erythromycin A is a semi-synthetic macrolide antibiotic, which is derived from the naturally occurring antibiotic erythromycin. This compound is structurally modified to enhance its pharmacokinetic properties and antibacterial spectrum. By altering the erythromycin molecule, 9-Deoxo-9a-aza-9a-homo erythromycin A introduces a nitrogen atom into the lactone ring, thereby modifying its interaction with bacterial ribosomes.

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: (%) Min. 90%

Forma y color: White Powder

Peso molecular: 734.96 g/mol

Ref: 3D-AD21039

Azaerythromycin (AZAE)

CAS: 76801-85-9

Fórmula: C₃₇H₃₀N₂O₁₂

Forma y color: White, Crystalline powder

Peso molecular: 734.96

Ref: SR-59070

Azathramycin

CAS: 76801-85-9

Pureza: 98%

Peso molecular: 734.969

Ref: 10-F987657

Azithromycin impurity A

CAS: 76801-85-9

Azithromycin impurity A is an impurity of azithromycin that has been shown to have antibacterial activity in test organisms. It is a crystalline compound, which can be isolated from the antibiotic erythromycin by recrystallization. Impurity A has a molecular weight of 543.3 and can be identified by its X-ray powder diffraction pattern. The chemical formula for impurity A is C12H15N2O4S2 with an elemental composition of C, H, N, O, and S.

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: Min. 95 Area-%

Forma y color: Powder

Peso molecular: 735.00 g/mol

Ref: 3D-FA63629