CAS 775294-82-1

SBE13

CAS: 775294-82-1

SBE13 is a selective and potent inhibitor of Plk1 (IC50: 200 pM). SBE13 has a weak effect on Plk2 or Plk3 with IC50 values of >66 μM and 875 nM respectively.

Fórmula: C₂₄H₂₇ClN₂O₄

Forma y color: Solid

Peso molecular: 442.94

Ref: TM-T62591

SBE13

Producto controlado

CAS: 775294-82-1

SBE13 is a molecule that inhibits the activity of the proteasome. It has been shown to have anti-cancer effects in vitro and in vivo, with an effective dose for inhibiting cancer cell proliferation at 1 μM. SBE13 binds to the 5-membered heteroaryl ring of plk1 and inhibits its kinase activity. This inhibition leads to decreased phosphorylation of glycogen synthase kinase 3β (GSK3β) and increased phosphorylation of cyclin D1, leading to a decrease in the rate of cell cycle progression. SBE13 also inhibits caco-2 cells proliferation, cervical cancer cells proliferation, and mcf-7 cell growth by interfering with cell cycle progression.

Fórmula: C₂₄H₂₇ClN₂O₄

Pureza: Min. 95%

Peso molecular: 442.9 g/mol

Ref: 3D-AGB29482