CAS 7770-78-7

(-)-Arctigenina

Descripción:

(-)-Arctigenina es un compuesto lignano que se encuentra de forma natural, principalmente en varias plantas, incluida la raíz de bardana (Arctium lappa). Se caracteriza por su estructura fenólica, que contribuye a sus actividades biológicas. El compuesto exhibe una variedad de propiedades farmacológicas, incluidas efectos antiinflamatorios, antioxidantes y potenciales efectos anticancerígenos. Se ha estudiado (-)-Arctigenina por su capacidad para modular diversas vías de señalización, lo que puede influir en la proliferación celular y la apoptosis. Además, ha mostrado promesas en la protección contra enfermedades neurodegenerativas debido a sus propiedades neuroprotectoras. La sustancia es típicamente soluble en disolventes orgánicos y tiene una solubilidad limitada en agua, lo que puede afectar su biodisponibilidad. Su fórmula molecular refleja una disposición compleja de átomos de carbono, hidrógeno y oxígeno, lo que contribuye a sus diversas actividades biológicas. En general, (-)-Arctigenina es de gran interés en la química medicinal y la farmacología por sus posibles aplicaciones terapéuticas.

Fórmula: C₂₁H₂₄O₆

InChI: InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3

Clave InChI: InChIKey=NQWVSMVXKMHKTF-JKSUJKDBSA-N

SMILES: C([C@@H]1[C@@H](CC2=CC(OC)=C(OC)C=C2)COC1=O)C3=CC(OC)=C(O)C=C3

Sinónimos:

• (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-
• 4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• Arctidine
• (-)-Arctigenin
• (-)-Arctigenin
• Arctigenin
• dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)-
• (3R,4R)-3-(3-Methoxy-4-hydroxybenzyl)-4-(3,4-dimethoxybenzyl)tetrahydrofuran-2-one
• 2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]
• 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl]
• ARCTIGENIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R)
• ARCTIGENIN(P)
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran-2-one
• (3R)-3α-(3-Methoxy-4-hydroxybenzyl)-4β-(3,4-dimethoxybenzyl)-4,5-dihydrofuran-2(3H)-one

ARCTIGENIN

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 372.4117

Ref: IN-DA005GJC

Arctigenin

CAS: 7770-78-7

Arctigenin

Pureza: ≥95%

Peso molecular: 372.41g/mol

Ref: 54-BUP00018

(-)-Arctigenin

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Pureza: >95.0%(GC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 372.42

Ref: 3B-A3117

Arctigenin

CAS: 7770-78-7

Arctigenin, naturally occurring in Bardanae fructus, Saussurea medusa, Arctium lappa L., Torreya nucifera and Ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities, it can potently inhibit the activity of MKK1 in vitro with the IC(50) value of 1 nM, and inhibit activation of MAP kinases including ERK1/2, p38 kinase and JNK through the inhibition of MKK activities, leading to AP-1 inactivation, which might, at least in part, contribute to the inhibition of TNF-α production, inhibits expression via suppressing JAK-pathway in macrophages.[1,2]

Fórmula: C₂₁H₂₄O₆

Pureza: 95%~99%

Forma y color: Powder

Peso molecular: 372.417

Ref: BP-BP0186

Arctigenin

CAS: 7770-78-7

(-)-Arctigenin ((-)-Arctigenin) is found in burdock.

Fórmula: C₂₁H₂₄O₆

Pureza: 98% - 99.51%

Forma y color: Solid

Peso molecular: 372.41

Ref: TM-T2957

Arctigenin

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Peso molecular: 372.42

Ref: 7W-GY3454

Arctigenin

CAS: 7770-78-7

Lactone

Fórmula: C₂₁H₂₄O₆

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 372.42

Ref: 5G-80354

Arctigenin

Producto controlado

CAS: 7770-78-7

Applications Arctigenin is a plant ligan associated with anticancer and antioxidant properties.
References Heinonen, S., et al.: J. Agric. Food Chem., 49, 3178-3186 (2001); Cai, Y., et al.: Life Sci., 78, 2877-2888 (2006)

Fórmula: C₂₁H₂₄O₆

Forma y color: Neat

Peso molecular: 372.41

Ref: TR-A766580

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a lignan compound, which is naturally derived from certain plant species, primarily found in the seeds of Arctium lappa, commonly known as burdock. The compound exhibits a diverse mode of action, primarily noted for its ability to inhibit the proliferation of cancer cells through apoptosis induction, cell cycle arrest, and modulation of various signaling pathways. Additionally, it exerts antiviral effects by targeting viral replication processes and exhibits anti-inflammatory properties by downregulating pro-inflammatory cytokines.

Fórmula: C₂₁H₂₄O₆

Pureza: Min. 94.0 Area-%

Peso molecular: 372.41 g/mol

Ref: 3D-Q-100825

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a natural lignan, which is an active compound isolated from plants such as Arctium lappa (greater burdock) and other members of the Asteraceae family. It acts via several biochemical pathways, notably by inhibiting cellular proliferation and inducing apoptosis in certain cancer cell lines. Additionally, (-)-Arctigenin can modulate immune responses and possesses anti-inflammatory and antiviral properties by interfering with viral replication processes.

Fórmula: C₂₁H₂₄O₆

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 372.41 g/mol

Ref: 3D-FA41645