CAS 78113-36-7

Romurtide

Descripción:

Romurtide, con el número CAS 78113-36-7, es un péptido sintético que ha sido investigado por sus posibles aplicaciones terapéuticas, particularmente en el campo de la inmunología y la oncología. Se conoce por su capacidad para estimular el sistema inmunológico, específicamente mejorando la actividad de las células T y las células asesinas naturales, que desempeñan roles cruciales en la defensa del cuerpo contra tumores e infecciones. Romurtide a menudo se clasifica como un inmunomodulador y se ha estudiado por sus efectos en varios tipos de cáncer, así como por su potencial para mejorar las respuestas inmunitarias en pacientes que se someten a quimioterapia. La sustancia se administra típicamente por inyección y se ha evaluado en ensayos clínicos por su seguridad y eficacia. Al igual que muchos péptidos, su estabilidad y biodisponibilidad pueden verse influenciadas por factores como la formulación y el método de entrega. En general, Romurtide representa un área prometedora de investigación en el desarrollo de estrategias inmunoterapéuticas.

Fórmula: C₄₃H₇₈N₆O₁₃

InChI: InChI=1/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)/t28-,29+,31+,32+,33+,36+,37+,38+,43?/m0/s1

Clave InChI: InChIKey=IKSJCVFYCIKDTB-GZZWOGMVSA-N

SMILES: [C@H]([C@@H](NC(C)=O)C=O)(O[C@@H](C(N[C@H](C(N[C@H](CCC(N[C@@H](CCCCNC(CCCCCCCCCCCCCCCCC)=O)C(O)=O)=O)C(N)=O)=O)C)=O)C)[C@@H]([C@@H](CO)O)O

Sinónimos:

• (2R)-2-{[(4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-(acetylamino)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoyl]amino}-6-(octadecanoylamino)hexanoic acid (non-preferred name)
• 1: PN: WO2009033811 PAGE: 103 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysine, N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl-<smallcap>D</span>-α-glutaminyl-N⁶-(1-oxooctadecyl)-
• <span class="text-smallcaps">L</smallcap>-Lysine, N²-[N²-[N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl]-<smallcap>D</span>-α-glutaminyl]-N⁶-(1-oxooctadecyl)-
• Ac-Muramyl-Ala-D-Glu(Lys(Stearoyl)-Oh)-Nh2
• Dj 7041
• MDP-Lys(L 18)
• Muroctasin
• Muroctasine
• N-(N-Acetylmuramoyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-α-glutaminyl-N⁶-(1-oxooctadecyl)-<smallcap>L</span>-lysine
• N^α-Acetylmuramoyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-isoglutaminyl-N^ε-stearoyl-<smallcap>L</span>-lysine
• Nopia
• Romurtide
• N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-L-lysine
• L-Lysine, N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N6-(1-oxooctadecyl)-
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-
• Nα-Acetylmuramoyl-L-alanyl-D-isoglutaminyl-Nε-stearoyl-L-lysine
• C13187
• N2-[(N-Acetylmuramoyl)-L-Ala-D-γGln-]-N6-stearoyl-L-Lys-OH
• n(sup2)-((n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl)-n(sup6)-stearoyl-l-ly
• N-acetylmuramyl-ala-D-isoglutaminyl-*N-epsilon-st
• l-lysine,n(sup2),(n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutaminyl
• N^<2>^-[N^<2>^-[N-(N-Acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N^<6>^-(1-oxooctadecyl)-L-lysine
• n-acetylmuramyl-ala-d-isoglutaminyl-nε-stearoyl-lys
• Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH
• Ac-MuraMyl-Ala-D-Isogln-Lys(stearoyl)-OH, Muroctasin, RoMurtide, MDP-Lys(L 18)
• N-Acetylmuramyl-alanyl-D-isoglutaminyl-N'-stearoyl-lysine
• Na-Acetylmuramyl-L-alanyl-D-isoglutaminyl-Ne-stearoyl-L-lysine
• )-n(sup6)-(1-oxooctadecyl)-
• N2-[(R)-5-Amino-4-[[N-(N-acetylmuramoyl)-L-alanyl]amino]-1,5-dioxopentyl]-N6-stearoyl-L-lysine
• Muroetasin
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)- (9CI)
• N-ACETYLMURAMYL-ALA-D-ISOGLUTAMINYL-N-EP SILON-STEA
• Ac-muramyl-A
• Romurtide USP/EP/BP
• AC-MURAMYL-ALA-D-ISOGLN-LYS(STEAROYL)-OH

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH₂

CAS: 78113-36-7

The investigation of the adjuvant activity of this muramyl peptide on humoral and cellular immune responses showed that it augments the mitogenic responses of splenic lymphocytes to phytohemagglutinin and lipopolysaccharide and the formation of antibodies to sheep erythrocytes in mice. In addition, it potentiated polyclonal B cell activation in vivo and in vitro.

Fórmula: C₄₃H₇₈N₆O₁₃

Pureza: > 98%

Forma y color: White Powder

Peso molecular: 887.13

Ref: 01-4015937

Romurtide

CAS: 78113-36-7

Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.

Fórmula: C₄₃H₇₈N₆O₁₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 887.126

Ref: TM-TP2405

Romurtide

CAS: 78113-36-7

Fórmula: C₄₃H₇₈N₆O₁₃

Pureza: ≥ 98.0%

Forma y color: White powder

Peso molecular: 887.11

Ref: 7W-GP1044

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2

CAS: 78113-36-7

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 is a synthetic peptide that was designed to mimic the sequence of muramyl dipeptide (MDP), which is found in bacterial cell walls. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 binds to the protein albumin, which is an important component of human blood plasma and has been shown to be elevated in patients with autoimmune diseases. This peptide also inhibits the activity of metal hydroxides, such as aluminum hydroxide and calcium hydroxide, by binding to their surface, reducing their antimicrobial activity. The effect on locomotor activity has not been studied. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 may have effects on various cells types including macrophages and T

Fórmula: C₄₃H₇₈N₆O₁₃

Pureza: Min. 95%

Forma y color: Solid

Peso molecular: 887.11 g/mol

Ref: 3D-FA110464