CAS 78164-00-8

vineomicina A1

Descripción:

vineomicina A1 es un compuesto antibiótico de origen natural que pertenece a la clase de los antibióticos glicopéptidos. Se produce mediante la fermentación de ciertas cepas de la bacteria Streptomyces. Este compuesto exhibe una potente actividad antibacteriana, particularmente contra bacterias Gram-positivas, y se ha estudiado por su posible uso en la terapia del cáncer debido a sus propiedades citotóxicas. vineomicina A1 se caracteriza por su estructura compleja, que incluye una porción glicosilada que contribuye a su actividad biológica. El mecanismo de acción implica la interferencia con la síntesis de la pared celular bacteriana, lo que lleva a la lisis celular. Además, vineomicina A1 ha mostrado cierta eficacia en la inhibición del crecimiento de células tumorales, lo que lo convierte en un tema de interés en la investigación oncológica. Su estabilidad y solubilidad en varios disolventes son importantes para su aplicación tanto en entornos de laboratorio como clínicos. Sin embargo, al igual que muchos antibióticos, la aparición de resistencia y los posibles efectos secundarios requieren una cuidadosa consideración en su uso terapéutico.

Fórmula: C₄₉H₅₈O₁₈

InChI: InChI=1/C49H58O18/c1-22-30(50)9-13-37(60-22)64-33-11-15-39(62-24(33)3)66-46-26(5)59-35(19-32(46)52)27-7-8-28-41(43(27)54)44(55)29-17-18-48(57)21-47(6,20-36(53)49(48,58)42(29)45(28)56)67-40-16-12-34(25(4)63-40)65-38-14-10-31(51)23(2)61-38/h7-10,13-14,17-18,22-26,32-35,37-40,46,52,54,57-58H,11-12,15-16,19-21H2,1-6H3/t22-,23-,24-,25-,26+,32+,33-,34-,35+,37-,38-,39-,40-,46+,47-,48-,49-/m0/s1

Sinónimos:

• Antibiotic OS 4742 A(sub 1)
• Brn 5724539
• Os-4742 A1
• P 1894B
• Vineomycin A(sub 1)
• Benz(a)anthracene-1,7,12(2H)-trione, 9-(2,6-dideoxy-4-O-((2S-(2-alpha,5-beta(2S*,6R*),6-beta))-5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-beta-D-arabino-hexopyranosyl)-3-((5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, (3R-(3-alpha(2S*,5S*(2R*,6S*)6S*),4a-alpha,12a-alpha))-
• (1R)-1,5-anhydro-2,6-dideoxy-4-O-[(2S,5S,6S)-6-methyl-5-{[(2R,6S)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]-1-[(3R,4aR,12bS)-4a,8,12b-trihydroxy-3-methyl-3-{[(2S,5S,6S)-6-methyl-5-{[(2R,6S)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-1,7,12-trioxo-1,2,3,4,4a,7,12,12b-octahydrotetraphen-9-yl]-D-arabino-hexitol

Vineomycin A1; OS-4742-A1; P-1894-B

CAS: 78164-00-8

Fórmula: C₄₉H₅₈O₁₈

Pureza: 97.2%

Forma y color: Orange. Amorphous solid

Peso molecular: 935.0

Ref: 8R-CL0037

Vineomycin A1

CAS: 78164-00-8

Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.

Fórmula: C₄₉H₅₈O₁₈

Forma y color: Solid

Peso molecular: 934.974

Ref: TM-TN9044

Vineomycin A1

CAS: 78164-00-8

Vineomycin A1

Fórmula: C₄₉H₅₈O₁₈

Pureza: >80%

Forma y color: yellow solid

Peso molecular: 934.97g/mol

Ref: 54-BIBR1111

Vineomycin A1

CAS: 78164-00-8

Vineomycin A1 is a cytotoxic antibiotic, which is isolated from the fermentation broth of certain Streptomyces species. This compound is a member of the anthracycline class of antibiotics, known for their potent antitumor activity. Vineomycin A1 exerts its effects by intercalating into DNA, disrupting the DNA replication process and ultimately inducing apoptosis in rapidly dividing cells. This mode of action makes it a valuable tool in studying cellular responses to DNA damage and has potential implications in cancer research. Leveraging its ability to target malignant cells, Vineomycin A1 is primarily examined for its therapeutic potential in oncology, particularly in treating certain types of cancers that are resistant to standard therapies. As a research chemical, it enables scientists to gain insights into the mechanisms of drug resistance and DNA repair pathways, contributing to the development of novel cancer treatment strategies.

Fórmula: C₄₉H₅₈O₁₈

Pureza: Min. 95%

Peso molecular: 935.00 g/mol

Ref: 3D-DDA16400