CAS 78432-77-6

10-Deacetiltaxol

Descripción:

10-Deacetiltaxol, con el número CAS 78432-77-6, es un derivado del producto natural taxol, conocido por sus propiedades anticancerígenas. Este compuesto se caracteriza por la ausencia de un grupo acetilo en la posición C10, lo que lo distingue del taxol. Presenta una estructura policíclica compleja típica de los taxanos, con un núcleo de taxano que contribuye a su actividad biológica. 10-Deacetiltaxol es reconocido principalmente por su capacidad para estabilizar microtúbulos, inhibiendo así la división celular, que es un mecanismo crucial en el tratamiento del cáncer. El compuesto se estudia a menudo por sus posibles aplicaciones terapéuticas y puede exhibir diferentes grados de citotoxicidad contra diferentes líneas celulares cancerosas. Además, su solubilidad y estabilidad en sistemas biológicos pueden influir en su eficacia como agente terapéutico. En general, 10-Deacetiltaxol representa un compuesto importante en el campo de la química medicinal, particularmente en el desarrollo de agentes quimioterapéuticos.

Fórmula: C₄₅H₄₉NO₁₃

InChI: InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

Clave InChI: InChIKey=TYLVGQKNNUHXIP-MHHARFCSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinónimos:

• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Deacetylpaclitaxel
• 10-Deacetyltaxol
• 10-Deacetyltaxol A
• 10-Desacetylpaclitaxel
• 10-Desacetyltaxol
• 10-O-Deacetyltaxol
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Epi-10-deacetyl paclitaxel
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Paclitaxel EP Impurity G (10-Desacetyl Paclitaxel)

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Forma y color: Pink Solid

Peso molecular: 811.88

Ref: 4Z-P-286

10-Deacetyltaxol

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 811.88

Ref: 7W-GY7900

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol

Pureza: ≥90%

Peso molecular: 811.87g/mol

Ref: 54-BUP00167

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Fórmula: C₄₅H₄₉NO₁₃

Pureza: 95%~99%

Peso molecular: 811.881

Ref: BP-BP0012

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.

Fórmula: C₄₅H₄₉NO₁₃

Pureza: 94.63% - 99.93%

Forma y color: Solid

Peso molecular: 811.87

Ref: TM-T5165

10-Deacetyltaxol

CAS: 78432-77-6

Peso molecular: 811.881

Ref: 10-F986787

10-Desacetyl Paclitaxel

CAS: 78432-77-6

Impurity Paclitaxel - impurity G
Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.

Fórmula: C₄₅H₄₉NO₁₃

Forma y color: White To Off-White

Peso molecular: 811.87

Ref: TR-D288710

10-Desacetyl paclitaxel

CAS: 78432-77-6

10-Desacetyl paclitaxel is a form of paclitaxel that has been modified chemically. It is soluble in water and can be injected intravenously. 10-Desacetyl paclitaxel is used to treat inflammatory diseases, such as rheumatoid arthritis and psoriasis. This drug binds to the hydroxyl groups on the surface of the bacterial cell wall and prevents the formation of covalent linkages with polysaccharides, which leads to its increased patency in bacterial cells. 10-Desacetyl paclitaxel has also been shown to inhibit the activity of certain enzymes that are involved in synthesis of DNA, RNA, and proteins. This inhibition results in cell death by apoptosis or necrosis. The increase in viability after treatment with 10-desacetyl paclitaxel was observed for both gram-positive bacteria (e.g., Bacillus subtilis) and gram-negative bacteria (e.g., Escher

Fórmula: C₄₅H₄₉NO₁₃

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 811.87 g/mol

Ref: 3D-FD21126

Paclitaxel EP Impurity G

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Peso molecular: 811.88

Ref: ST-EA-CP-P36007