CAS 789-61-7

2'-Desoxi-6-tioguanosina

Descripción:

2'-Desoxi-6-tioguanosina es un análogo de nucleósido que presenta un grupo tiol en la posición 6 de la base de guanina, reemplazando el oxígeno típico que se encuentra en los nucleósidos estándar. Esta modificación otorga propiedades bioquímicas únicas, lo que lo hace de interés en varios campos, incluida la química medicinal y la biología molecular. El compuesto consiste en un azúcar desoxirribosa unido a una base de guanina modificada, que puede participar en la síntesis de ácidos nucleicos y potencialmente interferir con los procesos celulares normales. Su estructura le permite ser incorporado en el ADN, donde puede afectar la replicación y la transcripción. 2'-Desoxi-6-tioguanosina ha sido estudiado por sus posibles aplicaciones terapéuticas, particularmente en el contexto de tratamientos antivirales y anticancerígenos, ya que puede imitar nucleósidos naturales y alterar la función de los ácidos nucleicos en patógenos o células cancerosas. Además, su único grupo tiol puede participar en reacciones redox, influyendo en las vías de señalización celular. En general, este compuesto representa un área significativa de investigación debido a su potencial para modular sistemas biológicos.

Fórmula: C₁₀H₁₃N₅O₃S

InChI: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1

Clave InChI: InChIKey=SCVJRXQHFJXZFZ-KVQBGUIXSA-N

SMILES: S=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Sinónimos:

• 2′-Deoxythioguanosine
• Thioguanine deoxyriboside
• Guanosine, 2′-deoxy-6-thio-
• 2′-Deoxy-6-thioguanosine
• 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: 98%

Forma y color: Solid

Peso molecular: 283.3069

Ref: IN-DA00G38M

2''-Deoxy-6-thioguanosine

CAS: 789-61-7

Ref: 7W-GN2065

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine

Pureza: ≥95%

Peso molecular: 283.31g/mol

Ref: 54-BUP06562

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: 97.52%

Forma y color: Solid

Peso molecular: 283.31

Ref: TM-T6746

2′-Deoxy-6-Thio-Guanosine

CAS: 789-61-7

Fórmula: C₁₀H₁₃N₅O₃S

Peso molecular: 283.31

Ref: 4Z-G-2462

2'-Deoxy-6-thio Guanosine

Producto controlado

CAS: 789-61-7

Applications Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);

Fórmula: C₁₀H₁₃N₅O₃S

Forma y color: Neat

Peso molecular: 283.31

Ref: TR-D281650

2'-Deoxy-6-thioguanosine

CAS: 789-61-7

2'-Deoxy-6-thioguanosine is a purine nucleoside analog that inhibits the activation of transcription factors such as nuclear factor kappa-B (NF-κB) and activator protein 1 (AP-1). It also inhibits the synthesis of proinflammatory cytokines, such as IL-1β, IL-6, and TNFα. The matrix effect is an important factor in the prevention of tumor progression. 2'-Deoxy-6-thioguanosine has been shown to inhibit cell proliferation and induce apoptosis in squamous cell carcinoma cells by modulating the expression of HLA class II molecules on tumors. It also prevents invasion by blocking matrix metalloproteinase activity. 2'-Deoxy-6-thioguanosine has been found to be effective against bowel diseases such as ulcerative colitis and Crohn's disease, as well as infectious diseases such as HIV/AIDS.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: Min. 97 Area-%

Forma y color: Powder

Peso molecular: 283.31 g/mol

Ref: 3D-ND08563

2'-Deoxy-6-thioguanosine - Bio-X ™

CAS: 789-61-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 283.31 g/mol

Ref: 3D-BD300155

6-Thio-2′-deoxyguanosine

CAS: 789-61-7

Pureza: 98%

Peso molecular: 283.310

Ref: 10-F980551

2'-Deoxy-6-thio Guanosine-13C, 15N2

Producto controlado

CAS: 789-61-7

Applications 2'-Deoxy-6-thio Guanosine-13C, 15N2 is labelled 2'-Deoxy-6-thio Guanosine (D281650) which is a Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999)

Fórmula: CC₉H₁₃₁₅N₂N₃O₃S

Forma y color: Neat

Peso molecular: 286.286

Ref: TR-D281652