CAS 78919-13-8

Iloprost

Descripción:

Iloprost es un análogo sintético de la prostaciclina (PGI2), utilizado principalmente por sus propiedades vasodilatadoras y antiagregantes plaquetarios. Se caracteriza por su capacidad para imitar los efectos de la prostaciclina natural, lo que lleva a la relajación del músculo liso vascular y la inhibición de la activación plaquetaria. Iloprost se administra típicamente por inhalación o por vía intravenosa y se utiliza en el tratamiento de la hipertensión arterial pulmonar y otras condiciones que requieren vasodilatación. La sustancia tiene una vida media relativamente corta, lo que requiere infusión continua o múltiples dosis para efectos terapéuticos sostenidos. Su estructura química incluye un sistema de anillos bicíclicos, que contribuye a su actividad biológica. Iloprost es conocido por sus efectos secundarios, que pueden incluir dolor de cabeza, rubor y trastornos gastrointestinales. Debido a sus potentes efectos en el sistema cardiovascular, es esencial un monitoreo cuidadoso durante el tratamiento. En general, Iloprost representa una opción terapéutica significativa en el manejo de condiciones asociadas con el flujo sanguíneo comprometido y la disfunción vascular.

Fórmula: C₂₂H₃₂O₄

InChI: InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1

Clave InChI: InChIKey=HIFJCPQKFCZDDL-ACWOEMLNSA-N

SMILES: C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]

Sinónimos:

• (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane
• (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic acid
• (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• (5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• Ciloprost
• Endoprost
• Ilomedin
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-, (5E)-
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)-
• Zk 36374

Iloprost

CAS: 78919-13-8

Fórmula: C₂₂H₃₂O₄

Pureza: 98%

Forma y color: Liquid

Peso molecular: 360.4871

Ref: IN-DA0054KQ

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

CAS: 78919-13-8

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

Pureza: 98%

Peso molecular: 360.49g/mol

Ref: 54-OR1062959

Iloprost

CAS: 78919-13-8

Fórmula: C₂₂H₃₂O₄

Peso molecular: 360.49

Ref: 4Z-I-098001

Iloprost

CAS: 78919-13-8

Stability Light and Temperature Sensitive
Applications A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
References Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008); Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997); Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995);

Fórmula: C₂₂H₃₂O₄

Forma y color: Colourless To Light Yellow

Peso molecular: 360.49

Ref: TR-I267300

Iloprost

CAS: 78919-13-8

Iloprost is a cyclase inhibitor that is used to treat pulmonary hypertension. It relaxes the smooth muscle cells in the lungs, which causes an increase in blood flow and oxygen levels to the heart and other organs. Iloprost also decreases the production of PGE2 and lowers blood pressure. Iloprost has been shown to be effective in treating chronic viral hepatitis and pulmonary diseases such as primary pulmonary hypertension. This drug can cause hypotension, so it should not be taken by patients with low blood pressure or those who are taking other drugs that can cause hypotension.

Fórmula: C₂₂H₃₂O₄

Pureza: Min. 95%

Forma y color: Solidified Mass

Peso molecular: 360.49 g/mol

Ref: 3D-FH24541

Iloprost

CAS: 78919-13-8

Iloprost (Ciloprost) is an inhibitor of platelet aggregation and vasodilatation used in the study of cardiovascular disease.

Fórmula: C₂₂H₃₂O₄

Forma y color: Colorless Oil

Peso molecular: 360.49

Ref: TM-T15560