CAS 79217-60-0

Ciclosporina

Descripción:

Ciclosporina, también conocido como Ciclosporinae A, es un polipéptido cíclico compuesto por 11 aminoácidos y es principalmente conocido por sus propiedades inmunosupresoras. Se produce por el hongo Tolypocladium inflatum y se utiliza ampliamente en entornos clínicos, particularmente en trasplantes de órganos y enfermedades autoinmunes, para prevenir el rechazo de órganos y manejar condiciones como la artritis reumatoide y la psoriasis. Ciclosporina funciona inhibiendo la actividad de los linfocitos T, suprimiendo así la respuesta inmune. Es lipofílico, lo que afecta su absorción y distribución en el cuerpo, y generalmente se administra por vía oral o intravenosa. El fármaco se metaboliza principalmente en el hígado por las enzimas del citocromo P450, lo que lleva a interacciones significativas con otros medicamentos. Los efectos secundarios comunes incluyen nefrotoxicidad, hipertensión y un mayor riesgo de infecciones. Debido a su estrecho índice terapéutico, es esencial un monitoreo cuidadoso de los niveles en sangre para asegurar la eficacia mientras se minimiza la toxicidad. En general, Ciclosporina sigue siendo un agente terapéutico crítico en la medicina moderna, particularmente en la inmunología de trasplantes.

Fórmula: Unspecified

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Sinónimos:

• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Antibiotic S 7481F1
• Cyclosporin
• Cyclosporina
• Cyclosporine
• Cyclosporins
• Restasis
• cyclosporin A
• MeSH ID: D003524

Cyclosporine

CAS: 79217-60-0

Cyclosporine

Pureza: ≥98%

Peso molecular: 1202.61g/mol

Ref: 54-BUP16995

Cyclosporine

CAS: 79217-60-0

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99.68%

Forma y color: White Powder

Peso molecular: 1202.61

Ref: TM-T6459

Cyclosporine

CAS: 79217-60-0

Cyclosporine is a drug that belongs to the group of non-steroidal anti-inflammatory drugs. It is used as an immunosuppressant, most commonly in organ transplantations. Cyclosporine has been shown to bind to human MDR1 and inhibit its activity. This binding prevents the efflux of cyclosporin from cells, thereby increasing its concentration in tissues, which leads to the suppression of immune responses. Cyclosporine has also been shown to have a protective effect on ischemic preconditioning, which occurs when a cell is briefly deprived of oxygen and then given an increased level of oxygen. This effect may be due to cyclosporine's ability to inhibit toll-like receptor 4 (TLR4) signaling, which can lead to inflammation and tissue injury. Cyclosporin binds with high specificity and affinity to DNA at the CpG sites found in promoters of genes such as interleukin 2 (IL2), IL

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: Min. 98 Area-%

Forma y color: White To Off-White Solid

Peso molecular: 1,202.61 g/mol

Ref: 3D-FC31886