CAS 79794-75-5

Loratadina

Descripción:

Loratadina es un antihistamínico de segunda generación comúnmente utilizado para aliviar los síntomas de alergia como la nariz moquienta, los estornudos y los ojos irritados. Se caracteriza por su antagonismo selectivo de los receptores H1 periféricos, lo que ayuda a minimizar los efectos secundarios comunes asociados con los antihistamínicos de primera generación, como la sedación. Loratadina es un polvo cristalino blanco a casi blanco que es prácticamente insoluble en agua pero soluble en disolventes orgánicos como el etanol y el metanol. Su fórmula química es C22H23ClN2O2, y tiene un peso molecular de aproximadamente 382.88 g/mol. Loratadina se administra a menudo por vía oral y tiene una larga duración de acción, lo que permite una dosificación una vez al día. Se metaboliza en el hígado a su metabolito activo, desLoratadina, que contribuye a sus efectos antihistamínicos. Debido a su baja penetración de la barrera hematoencefálica, Loratadina es menos probable que cause somnolencia en comparación con los antihistamínicos más antiguos, lo que lo convierte en una opción preferida para las personas que necesitan alivio de los síntomas alérgicos sin sedación.

Fórmula: C₂₂H₂₃ClN₂O₂

InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

Clave InChI: InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(OCC)=O)CC4)=CC1

Sinónimos:

• 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
• 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 1-piperidinecarboxylic acid deriv.
• 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
• Alavert
• Anhissen
• Bonalerg
• Civeran
• Claratyne
• Claritin
• Claritine
• Clarityn
• Clarityne
• Clarotadin
• Cronopen
• Erolin
• Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
• Flonidan
• Fristamin
• Histaloran
• Klarifer
• Klaritin
• Lertamine
• Lisino
• Lomilan
• Loracert
• Loradex
• Loranox
• Lorastine
• Loratidine
• Loratyne
• Lorfast
• Lowadina
• Optimin
• Polaratyne
• Pylor
• Restamine
• Sch 29851
• Sensibit
• Sohotin
• Symphoral
• Tadine
• Velodan
• Zeos

Desloratadine EP Impurity C

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Peso molecular: 382.88

Ref: ST-EA-CP-D15003

Loratadine - Bio-X ™

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 382.88 g/mol

Ref: 3D-BL164637

Loratadine

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 98.5 To 101.0%

Forma y color: Powder

Peso molecular: 382.88 g/mol

Ref: 3D-FL24933

11-(N-Hydroxy) Loratadine 1-Oxide

Producto controlado

CAS: 79794-75-5

Fórmula: C₁₉H₁₉ClN₂O₂

Forma y color: Neat

Peso molecular: 342.819

Ref: TR-H947746