CAS 79902-63-9
:Simvastatina
Descripción:
Simvastatina es un agente sintético reductor de lípidos que pertenece a la clase de las estatinas, utilizado principalmente para manejar la hiperlipidemia y reducir el riesgo de enfermedades cardiovasculares. Su estructura química presenta un anillo de lactona y un grupo ácido hidroxílico, que son cruciales para su actividad biológica. La sustancia actúa inhibiendo la HMG-CoA reductasa, una enzima involucrada en la biosíntesis de colesterol en el hígado, reduciendo así los niveles de colesterol de lipoproteínas de baja densidad (LDL) y triglicéridos, mientras que aumenta modestamente el colesterol de lipoproteínas de alta densidad (HDL). Simvastatina se administra típicamente por vía oral y es conocido por su relativamente alta biodisponibilidad, aunque sufre un extenso metabolismo de primer paso en el hígado. Los efectos secundarios comunes pueden incluir dolor muscular, anormalidades en las enzimas hepáticas y trastornos gastrointestinales. Es importante monitorear la función hepática y la salud muscular durante el tratamiento. Simvastatina a menudo se prescribe junto con modificaciones en el estilo de vida, como dieta y ejercicio, para mejorar sus efectos reductores de colesterol. Como con todos los medicamentos, es esencial usar Simvastatina bajo la guía de un profesional de la salud.
Fórmula:C25H38O5
InChI:InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21?,23?/m0/s1
Clave InChI:InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]
Sinónimos:- (+)-Simvastatin
- Apo-Simva
- Apo-Simvastatin
- Bestatin 20
- Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*,4S*),8aβ]]-
- Cholestat
- Co-Simvastatin
- Denan
- Egilipid
- Eucor
- Kolestevan
- L 644128-000U
- Lipex
- Lipinorm
- Liponorm
- Lipovas
- Lodales
- Lycostatin
- Mk 733
- Modutrol
- Nor-Vastina
- Novo-Simvastatin
- Pms-simvastatin
- Rechol
- Simastin 20
- Simcor
- Simcovas
- Simgal
- Simi 20
- Simlip
- Simlip 20
- Simlo 20
- Simlup 20
- Simovil
- Simratio
- Simvacard
- Simvachol
- Simvacor
- Simvahexal
- Simvas
- Simvastatin lactone
- Simvasterol
- Simvastol
- Simvofix
- Simvotin
- Sinvacor
- Sinvascor
- Sivastin
- Starstat 20
- Statin
- Synvinolin
- Valemia
- Vasilip
- Vastan
- Vazilip
- Velostatin
- Ximve
- Zocor
- Zocor Forte
- Zocord
- Zorced
- Zosta
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
- [(3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
- (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
- Simvastatin USP23,24
- SIMVASTATIN,USP
- mk-0733
- butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy
- 2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
- l644128-000u
- SimvastatineUsp25
- SIMVASTATIN USP24
- (1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
- Zocor, MK-733, Liponorm
- SimvastatinC25H3805
- 7-beta,8-beta(2s*,4s*),8a-beta))-alph
- 2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester
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Encontrado 19 productos.
Simvastatin
CAS:Fórmula:C25H38O5Pureza:>97.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:418.57Simvastatin
CAS:SimvastatinFórmula:C25H38O5Pureza:99.7%Forma y color:Off-WhitePeso molecular:418.27192SIMVASTATIN CRS
CAS:SIMVASTATIN CRSFórmula:C25H38O5Forma y color:Crystalline Powder. White. Powder., Crystalline Powder. White. Powder.Peso molecular:418.5662Simvastatin
CAS:Aromatic lactones used as drugsFórmula:C25H38O5Forma y color:PowderPeso molecular:418.56 g/mol(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
CAS:Fórmula:C25H38O5Pureza:98%Forma y color:SolidPeso molecular:418.5662Simvastatin
CAS:Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.Fórmula:C25H38O5Pureza:98.54% - 99.13%Forma y color:SolidPeso molecular:418.57Simvastatin
CAS:Fórmula:C25H38O5Pureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:418.57Simvastatin 100 µg/mL in Acetonitrile
CAS:Fórmula:C25H38O5Forma y color:Single SolutionPeso molecular:418.57Simvastatin
CAS:Producto controlado<p>Applications Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>Fórmula:C25H38O5Forma y color:White To Off-WhitePeso molecular:418.57Simvastatin - Bio-X ™
CAS:<p>Simvastatin is a lipid-lowering agent that belongs to the group of statins. It is prescribed for the treatment of hypercholesterolemia, coronary heart diseases, and other conditions related to high cholesterol levels. Simvastatin inhibits the production of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in the synthesis of cholesterol.<br>Simvastatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C25H38O5Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:418.57 g/molSimvastatin
CAS:<p>HMG-CoA reductase inhibitor</p>Fórmula:C25H38O5Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:418.57 g/molSimvastatin
CAS:<p>M03997 - Simvastatin</p>Fórmula:C25H38O5Pureza:98%Forma y color:SolidPeso molecular:418.574
![(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydr…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0032AJ.jpg&w=3840&q=75)
