CAS 79952-44-6

Epilovastatina

Descripción:

Epilovastatina, con el número CAS 79952-44-6, es un compuesto sintético que pertenece a la clase de las estatinas, que se utilizan principalmente por sus propiedades para reducir el colesterol. Funciona inhibiendo la enzima HMG-CoA reductasa, un jugador clave en la biosíntesis de colesterol en el hígado. Esta acción ayuda a reducir los niveles de lipoproteína de baja densidad (LDL) y triglicéridos, mientras que potencialmente aumenta el colesterol de lipoproteína de alta densidad (HDL). Epilovastatina se caracteriza por su estructura química específica, que incluye un anillo de lactona y varios grupos funcionales que contribuyen a su actividad biológica. Se administra típicamente por vía oral y se ha estudiado por su eficacia en el manejo de la hiperlipidemia y la reducción del riesgo cardiovascular. Al igual que con otras estatinas, los efectos secundarios potenciales pueden incluir dolor muscular, alteraciones en las enzimas hepáticas y trastornos gastrointestinales. Su farmacocinética, que incluye absorción, metabolismo y excreción, es importante para determinar los regímenes de dosificación y comprender sus interacciones con otros medicamentos.

Fórmula: C₂₄H₃₆O₅

InChI: InChI=1/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14?,15?,16-,18+,19+,20-,21?,23-/m0/s1

Clave InChI: InChIKey=PCZOHLXUXFIOCF-YPQFMRJXSA-N

SMILES: O(C([C@@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Sinónimos:

• Epilovastatin
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2R)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(S*),3α,7β,8β(2S*,4S*),8aβ]]-
• Lovastatin epi-Isomer
• Simvastatin EP Impurity F/ Simvastatin Related Compound F (epi-Lovastatin/ Lovastatin epimer)
• Epilovastatin, 10 - 15% isoMers
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate
• Epi Lovastatin
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-H
• Simvastatin Impurity 6（EP-F）
• (R)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Simvastatin EP Impurity F (epi-Lovastatin)
• Epilovastatin, 95%, 10 - 15% isomers
• (2R)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
• Simvastatin EP Impurity
• Simvastatin EP Impurity F (epi-Lovastatin)/(2R)-2-Methylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl
• Simvastatin Impurity 6(Simvastatin EP Impurity F)

Epi Lovastatin ((1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate)

CAS: 79952-44-6

Lactones, nesoi

Fórmula: C₂₄H₃₆O₅

Forma y color: White Powder

Peso molecular: 404.25627

Ref: 45-1A10320

Simvastatin EP Impurity F (epi-Lovastatin)

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Forma y color: White To Off-White Solid

Peso molecular: 404.55

Ref: 4Z-S-128

(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-Methylbutanoate (Epilovastatin)

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Forma y color: Neat

Peso molecular: 404.54

Ref: 86-MM0158.06

Epi Lovastatin

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Peso molecular: 404.5

Ref: ST-EA-CP-L76020

Simvastatin EP Impurity F

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Peso molecular: 404.55

Ref: ST-EA-CP-S4006

Epi Lovastatin

Producto controlado

CAS: 79952-44-6

Impurity Simvastatin EP Impurity F
Applications Epi Lovastatin (Simvastatin EP Impurity F) is a Lovastatin impurity; an antihypercholesterolemic compound.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986),

Fórmula: C₂₄H₃₆O₅

Forma y color: Neat

Peso molecular: 404.54

Ref: TR-E588530

Epi lovastatin

CAS: 79952-44-6

Lovastatin is a cholesterol-lowering drug that acts by inhibiting the enzyme HMG-CoA reductase. It is also used to prevent organ rejection after a liver transplant, and has been shown to have anti-aging effects. Lovastatin has been shown to reduce serum cholesterol levels, which may be due to its ability to inhibit cellular proliferation in rat hepatocytes. This drug has been shown to have an effect on DNA damage and post-translational modification of proteins, as well as on health care foods. Lovastatin is a member of the statins family of drugs, which are all natural products isolated from fungi or bacteria. The active form of lovastatin is made in the laboratory by chemical synthesis, using recombinant DNA technology. The recombinant gene encoding lovastatin was cloned into an expression vector and expressed in Escherichia coli cells (E.M.).

Fórmula: C₂₄H₃₆O₅

Pureza: Min. 95%

Peso molecular: 404.54 g/mol

Ref: 3D-IE22709