CAS 817204-32-3

Citosina, N-benzoil-2'-desoxi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)-

Descripción:

Citosina, N-benzoil-2'-desoxi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)- es un derivado de nucleósido sintético caracterizado por la presencia de un grupo bencilo y dos funcionalidades de éster benzoato. Este compuesto presenta un azúcar ribosa modificado, específicamente una configuración de 2′-desoxi-2′-fluoro-2′-metilo, que mejora su estabilidad y bioactividad en comparación con los nucleósidos naturales. La estereoquímica (2′R) indica una disposición espacial específica de los sustituyentes alrededor de la parte azucarada, lo cual es crucial para su interacción con los objetivos biológicos. La presencia de flúor en la parte azucarada puede influir en las propiedades farmacocinéticas del compuesto, mejorando potencialmente su resistencia a las nucleasas. Este compuesto puede exhibir propiedades antivirales o anticancerígenas, lo que lo hace de interés en la química medicinal y el desarrollo de fármacos. Sus características estructurales únicas contribuyen a sus posibles aplicaciones en contextos terapéuticos, particularmente en el diseño de análogos de nucleósidos para el tratamiento de diversas enfermedades.

Fórmula: C₃₁H₂₆FN₃O₇

InChI: InChI=1S/C31H26FN3O7/c1-31(32)25(42-28(38)22-15-9-4-10-16-22)23(19-40-27(37)21-13-7-3-8-14-21)41-29(31)35-18-17-24(34-30(35)39)33-26(36)20-11-5-2-6-12-20/h2-18,23,25,29H,19H2,1H3,(H,33,34,36,39)/t23-,25-,29-,31-/m1/s1

Clave InChI: InChIKey=MXEQSUUFNWPUJH-RDWHIKKYSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](COC(=O)C2=CC=CC=C2)[C@H]1OC(=O)C3=CC=CC=C3)N4C(=O)N=C(NC(=O)C5=CC=CC=C5)C=C4

Sinónimos:

• ((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• (2R,3R,4R,5R)-5-4-benzamide-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• 2'-Deoxy-2'-Fluoro-2'-Methyl-N-(Phenylcarbonyl) Cytidine
• 3',5'-O-4-Tribenzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine
• Cytidine, N-benzoyl-2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-
• N-benzoyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-2-methylcytidine
• PSI-6130 derivative
• Sofosbuvir N-3
• [(2R,3R,4R,5R)-5-(4-benzamido-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4-fluoro-4-methyloxolan-2-yl]methyl benzoate
• Cytidine,N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-,3',5'-dibenzoate,(2'R)
• Cytidine, N-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-3',5'-Dibenzoate, (2'R)-
• Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, 3',5'-dibenzoate, (2'R)
• Sofosbuvir Intermediates1
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d
• Sofibute 12
• 2'-Defluro-2'-methylene Sofosbuvir
• Sofosbuvir INT 2
• Sofosbuvir Tri benzoyl fluoro cytidine
• N4,3',5'-tri-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-Methylcytidine
• SF-3
• R)-N-benzoyl-2&rsquo
• PSI-6130 derivative ISO 9001：2015 REACH
• Sofosbuvir int. N-3
• -dibenzoateCytidine
• Sofosbuvir Intermediate 2
• InterMediate of Sofosbuir
• (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)
• (2'R)-N-Bz-2'-deoxy-2'-F-2'-Methylcytidine 3',5'-dibenzoate
• -methyl-3&rsquo
• N-BENZOYL-2'-DEOXY-2'-FLUORO-2METHYL-3'5'-DIBENZOATE(2R)
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methyl-3',5'-dibenzoate Cytidine
• 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcarbonyl) cytidine　(N-3)
• Sofosbuvir Impurity 69
• (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• Sofosbuvir imp-5

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate,(2'R)-

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Pureza: 97%

Forma y color: Solid

Peso molecular: 571.5524

Ref: IN-DA00ID7G

Sofosbuvir Impurity 56

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Forma y color: White To Off-White Solid

Peso molecular: 571.56

Ref: 4Z-S-055063

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

CAS: 817204-32-3

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

Pureza: 98%

Peso molecular: 571.55g/mol

Ref: 54-PC104929

(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

CAS: 817204-32-3

Pureza: 97%

Peso molecular: 571.5609741210938

Ref: 10-F790039

Sofosbuvir Impurity 5

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Peso molecular: 571.6

Ref: ST-EA-CP-S45027

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d

CAS: 817204-32-3

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate) is a modified nucleoside that is an antiviral, anticancer, and activator of DNA synthesis. It has been shown to be the first synthetic nucleotide analogue to have significant activity against HIV in vitro. The synthesis of this compound starts with the diphosphate or monophosphate form of cytidine. The phosphate group is removed and replaced with a 2'R benzoyl group. This process is followed by fluorination and methylation steps. Finally, the 5' hydroxyl group is cleaved to give 2'R -N benzoyl 2'-deoxy-2'-fluoro-2'-

Fórmula: C₃₁H₂₆FN₃O₇

Pureza: Min. 95%

Peso molecular: 571.55 g/mol

Ref: 3D-NB98842