CAS 83150-76-9

Acetato de octreotida

Descripción:

Acetato de octreotida es un octapéptido sintético que imita la hormona natural somatostatina, que desempeña un papel crucial en la regulación de varios procesos fisiológicos, incluida la secreción de hormonas y la función gastrointestinal. Se utiliza principalmente en el campo médico para tratar condiciones como la acromegalia, ciertos tipos de tumores neuroendocrinos y la diarrea severa asociada con el síndrome carcinoide. La sustancia se caracteriza por su capacidad para inhibir la liberación de la hormona del crecimiento y otras hormonas, ayudando así a manejar los síntomas relacionados con la sobreproducción hormonal. Acetato de octreotida se administra típicamente por inyección subcutánea o intramuscular y tiene una vida media más larga en comparación con la somatostatina, lo que permite una dosificación menos frecuente. Su estructura química incluye una configuración cíclica que mejora su estabilidad y potencia. La forma de acetato mejora la solubilidad y la biodisponibilidad, lo que la hace adecuada para uso terapéutico. Al igual que con cualquier medicamento, los efectos secundarios potenciales pueden incluir trastornos gastrointestinales, reacciones en el sitio de inyección y alteraciones en el metabolismo de la glucosa, lo que requiere un monitoreo cuidadoso durante el tratamiento.

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂(C₂H₄O₂)

InChI: InChI=1/C49H66N10O10S2.C2H4O2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41;1-2(3)4/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64);1H3,(H,3,4)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+;/m1./s1

Sinónimos:

• L-cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl) propyl)-cyclic (2->7)-disulfide, (R-(R*,R*))
• OctreotideAcetate
• 10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (1:2)
• (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
• (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
• 1: PN: EP1118336 SEQID: 1 claimed protein
• 11: PN: US20030229017 PAGE: 13 claimed protein
• 14: PN: DE10147056 PAGE: 40 claimed protein
• 17: PN: US6268342 SEQID: 18 claimed protein
• 25: PN: WO2007081792 SEQID: 40 claimed protein
• L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide
• Longastatin
• Octreotide

Octreotide

CAS: 83150-76-9

A slow-release form of octreotide. Pamoate is the bivalent anion of pamoic acid (embonic acid, 4,4·-methylene-bis-(3-hydroxy-2-naphthoic acid)). CAS-number (octreotide pamoate): 135467-16-2.

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂

Pureza: > 98%

Peso molecular: 1019.26

Ref: 01-4076740

[R-(R*,R*)]-D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxy-methyl)propyl]-cysteinamide cyclic(2→7)-disulfide

CAS: 83150-76-9

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1019.2393

Ref: IN-DA003A7L

Octreotide-Phenylalanine-d8 Ditrifluoroacetate

CAS: 83150-76-9

Fórmula: C₄₉H₅₈D₈N₁₀O₁₀S₂·2C₂HF₃O₂

Peso molecular: 1027.30 2*114.02

Ref: 4Z-PO-036001

Octreotide

CAS: 83150-76-9

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂

Peso molecular: 1019.24

Ref: 7W-GP4986

Octreotide

CAS: 83150-76-9

Octreotide

Pureza: ≥98%

Peso molecular: 1019.24g/mol

Ref: 54-BUP00965

Octreotide

CAS: 83150-76-9

Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂

Pureza: 99.3% - 99.64%

Forma y color: White Powder

Peso molecular: 1019.24

Ref: TM-T2584

Octreotide-phenylalanine-d8 di-Trifluoroacetic Acid Salt

Producto controlado

CAS: 83150-76-9

Applications Labelled octapeptide analog of Somatostatin. A gastric antisecretory agent. Used in treatment of acromegaly.
References Bauer, W., et al.: Life Sci., 31, 1133 (1982), Plewe, G., et al.: Lancet, 2, 782 (1984), Kraenzlin, M.E., et al.: Experientia, 41, 738 (1985), del Pozo, E., et al.: Acta Endocrinol., 111, 433 (1986),

Fórmula: C₅₃H₆₀D₈F₆N₁₀O₁₄S₂

Forma y color: Neat

Peso molecular: 1255.34

Ref: TR-O239952

13C6-Lys Octreotide Trifluoroacetate

Producto controlado

CAS: 83150-76-9

Fórmula: C₄₃₁₃C₆H₆₆N₁₀O₁₀S₂•xC₂HF₃O₂

Forma y color: White To Off-White

Peso molecular: 1025.2011402

Ref: TR-O239958

Octreotide

CAS: 83150-76-9

Octreotide is a drug that belongs to the macrocycle class of polymers. It is used in the treatment of cancer, as well as for diseases such as diabetes mellitus and acromegaly. Octreotide has been shown to inhibit p-glycoprotein (P-gp) and other drug transporters, which leads to an increase in oral bioavailability. In addition, octreotide also inhibits cellular proliferation by interfering with intracellular signalling pathways and protein synthesis. This drug has been shown to have a wide range of biochemical properties and is being investigated as an investigational agent for the treatment of various cancers.

Fórmula: C₄₉H₆₆N₁₀O₁₀S₂

Pureza: Min. 95%

Peso molecular: 1,019.24 g/mol

Ref: 3D-OCT-3738-PI

Octreotide

CAS: 83150-76-9

Octreotide is a synthetic somatostatin analogue used for the treatment of acromegaly and neuroendocrine tumours. In clinical settings, Octreotide is used for the treatment of vasoactive intestinal peptide-secreting tumours, growth hormone producing tumours, and pituitary tumours. Octreotide also displays efficacy in the treatment of cluster headaches, acute haemorrhage from liver cirrhosis, malignant bowel obstruction, and idiopathic intracranial hypertension. Octreotide exerts its organ protective effects through several mechanisms, including its ability to decrease the levels of endotoxin and the proinflammatory cytokines TNF-alpha and IL-1β, and by inhibiting hepatocellular apoptosis. Octreotide also exerts a protective effect in hepatic ischemia-reperfusion (HIR) injury, which often occurs after complex liver surgeries such as major resection or transplantation.

Peso molecular: 1,018.4 g/mol

Ref: 3D-CRB1001491