CAS 83651-90-5

péptido relacionado con el gen de la calcitonina

Descripción:

El péptido relacionado con el gen de la calcitonina (CGRP) es un neuropeptido que desempeña un papel significativo en varios procesos fisiológicos, particularmente en el sistema nervioso y la regulación cardiovascular. Se deriva del gen de la calcitonina y es conocido por sus potentes efectos vasodilatadores, que contribuyen a la regulación del flujo sanguíneo y la presión arterial. El CGRP está compuesto por 37 aminoácidos y se encuentra principalmente en los sistemas nervioso central y periférico. Está involucrado en la transmisión del dolor y se ha implicado en la fisiopatología de la migraña, lo que lo convierte en un objetivo para los tratamientos de migraña. Además, el CGRP tiene roles en la inflamación y los procesos neurogénicos. El péptido existe en dos isoformas, alfa y beta, que difieren ligeramente en sus secuencias de aminoácidos pero comparten funciones biológicas similares. Debido a sus diversos roles, el CGRP es de gran interés en farmacología, particularmente en el desarrollo de terapias para la migraña y otras condiciones relacionadas con el dolor. Su número CAS, 83651-90-5, se utiliza para la identificación en bases de datos químicas y contextos regulatorios.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Sinónimos:

• .alpha.-CGRP (rat)
• H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bond)

α-CGRP (mouse, rat)

CAS: 83651-90-5

Induces elevation of cAMP and cGMP in rat aorta.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: 96.8%

Forma y color: White

Peso molecular: 3806.3

Ref: 01-4025897

α-CGRP, rat

CAS: 83651-90-5

Endogenous neuropeptide, potent vasodilator

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 3806.25

Ref: TM-TP2233

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.1 mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: Min. 95%

Peso molecular: 3,806.2 g/mol

Ref: 3D-PCG-4163-S

α-CGRP (mouse, rat)

CAS: 83651-90-5

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.  It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 3,806.25 g/mol

Ref: 3D-CRB1000889

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.5mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Pureza: Min. 95%

Ref: 3D-PCG-4163-V