CAS 842133-18-0

Canagliflozina

Descripción:

Canagliflozina es un medicamento utilizado principalmente en el manejo de la diabetes mellitus tipo 2. Pertenece a una clase de fármacos conocidos como inhibidores del cotransportador de sodio-glucosa 2 (SGLT2), que funcionan al prevenir la reabsorción de glucosa en los riñones, promoviendo así su excreción en la orina y reduciendo los niveles de glucosa en sangre. La fórmula química de Canagliflozina es C21H25ClO5S, y presenta un grupo sulfonilo, un moiety de clorobenceno y una estructura similar a la glucosa, que contribuyen a su actividad farmacológica. Canagliflozina se administra típicamente por vía oral y es conocido por sus beneficios potenciales más allá del control glucémico, incluyendo la pérdida de peso y la protección cardiovascular. Los efectos secundarios comunes pueden incluir infecciones del tracto urinario y deshidratación. Al igual que con cualquier medicamento, es esencial que los pacientes consulten a profesionales de la salud para obtener asesoramiento personalizado y monitoreo mientras utilizan Canagliflozina.

Fórmula: C₂₄H₂₅FO₅S

InChI: InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1

Clave InChI: InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC=3SC(=CC3)C4=CC=C(F)C=C4)=C(C)C=C2

Sinónimos:

• (1S)-1,5-Anhydro-1-C-(3-((5-(4-Fluorophenyl)-2-Thienyl)Methyl)-4-Methylphenyl)-D-Glucitol
• (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-<span class="text-smallcaps">D</span>-glucitol
• 1-(β-<span class="text-smallcaps">D</span>-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
• 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• Canaglifozin
• Invokana
• Jnj 24831754Zae
• Jnj 28431754
• Jnj 28431754Aaa
• Ta 7284
• Canagliflozin
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl
• (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
• Canagliflozi
• Cango coluMn net
• Canagliflozin WS
• Canagliflozin, >=98%
• Canaglifozion
• Canagliflozin-D6
• Canagliflozin(TA-7284)

Canagliflozin

CAS: 842133-18-0

Fórmula: C₂₄H₂₅FO₅S

Pureza: ≥ 98.0%

Forma y color: White to yellow solid

Peso molecular: 444.52

Ref: 7W-GX8313

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Pureza: ≥98%

Peso molecular: 444.52g/mol

Ref: 54-BUP17778

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Pureza: 99%

Peso molecular: 444.52g/mol

Ref: 54-PC108773

Canagliflozin

CAS: 842133-18-0

Fórmula: C₂₄H₂₅FO₅S

Forma y color: Off-White Solid

Peso molecular: 444.52

Ref: 4Z-C-152002

CANAGLIFLOZIN

CAS: 842133-18-0

Pureza: 95%

Forma y color: Solid

Peso molecular: 444.519989013672

Ref: 10-F857122

Canagliflozin (Standard)

CAS: 842133-18-0

Canagliflozin (Standard) is the standard substance of Canagliflozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).

Fórmula: C₂₄H₂₅FO₅S

Peso molecular: 444.52

Ref: TM-TMSM-0636

Canagliflozin

CAS: 842133-18-0

Forma y color: Neat

Ref: 86-MM3870.00

Canagliflozin

CAS: 842133-18-0

Fórmula: C₂₄H₂₅FO₅S

Forma y color: Neat

Peso molecular: 444.52

Ref: 04-CA10945450

Canagliflozin-13C6

CAS: 842133-18-0

Fórmula: C₁₈₁₃C₆H₂₅FO₅S

Peso molecular: 450.47

Ref: 4Z-C-152049

Canagliflozin

CAS: 842133-18-0

Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.

Fórmula: C₂₄H₂₅FO₅S

Pureza: 98.01% - >99.99%

Forma y color: Solid

Peso molecular: 444.52

Ref: TM-T1782

Canagliflozin

Producto controlado

CAS: 842133-18-0

Applications Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);

Fórmula: C₂₄H₂₅FO₅S

Forma y color: Colourless

Peso molecular: 444.52

Ref: TR-C175190

1,5-Dihydroxy Canagliflozin

Producto controlado

CAS: 842133-18-0

Fórmula: C₂₄H₂₇FO₆S

Forma y color: Neat

Peso molecular: 462.531

Ref: TR-D450431

Canagliflozin

CAS: 842133-18-0

Canagliflozin is a drug that has been approved for the treatment of type 2 diabetes. It is an inhibitor of sodium glucose transporter 2 (SGLT2) and reduces blood glucose levels by increasing urinary glucose excretion. Canagliflozin has been shown to have cardiac effects, which may be due to its ability to increase serum natriuretic peptide levels and decrease heart rate. This drug has also been shown to reduce cardiovascular disease activity in patients with type 2 diabetes. Canagliflozin is not active against c. glabrata, but it does inhibit SGLT1 in this organism.

Fórmula: C₂₄H₂₅FO₅S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 444.52 g/mol

Ref: 3D-MC58356

2'-Deshydroxymethyl-2'-Chloromethyl-6'-methoxy-canagliflozin

Producto controlado

CAS: 842133-18-0

Fórmula: C₂₅H₂₆ClFO₅S

Forma y color: Neat

Peso molecular: 492.987

Ref: TR-D221670

2'-Deshydroxymethyl-2'-Chloromethyl-canagliflozin

Producto controlado

CAS: 842133-18-0

Fórmula: C₂₄H₂₄ClFO₄S

Forma y color: Neat

Peso molecular: 462.961

Ref: TR-D221665

(3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-2-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Producto controlado

CAS: 842133-18-0

Fórmula: C₂₅H₂₇FO₆S

Forma y color: Neat

Peso molecular: 474.542

Ref: TR-F953260

Canagliflozin Tetra-acetyloxy

Producto controlado

CAS: 842133-18-0

Fórmula: C₃₂H₃₃FO₉S

Forma y color: Neat

Peso molecular: 612.662

Ref: TR-C175204

(2R,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2,3,4,5,6-pentahydroxyhexan-1-one

Producto controlado

CAS: 842133-18-0

Fórmula: C₂₄H₂₅FO₆S

Forma y color: Neat

Peso molecular: 460.515

Ref: TR-F590211