CAS 84625-61-6
:Itraconazol
Descripción:
Itraconazol es un agente antifúngico triazólico que se utiliza principalmente para tratar diversas infecciones fúngicas, incluidas las causadas por dermatofitos, levaduras y ciertos mohos. Funciona inhibiendo la síntesis de ergosterol, un componente esencial de las membranas celulares fúngicas, interrumpiendo así su integridad y función. Itraconazol se caracteriza por su relativamente baja solubilidad en agua, pero es más soluble en disolventes orgánicos, lo que influye en su biodisponibilidad. El compuesto tiene una fórmula molecular de C35H38Cl2N8O4S y presenta una estructura compleja que incluye un anillo triazólico. Se administra típicamente por vía oral o intravenosa, con su farmacocinética influenciada por factores como la ingesta de alimentos y los niveles de pH. Itraconazol es conocido por su amplio espectro de actividad contra varios hongos, pero también puede interactuar con otros medicamentos debido a sus efectos sobre las enzimas hepáticas. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, elevaciones de las enzimas hepáticas y posibles efectos cardiovasculares, lo que requiere un monitoreo durante el tratamiento.
Fórmula:C35H38Cl2N8O4
InChI:InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2
Clave InChI:InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N
SMILES:C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7
Sinónimos:- 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
- Candistat
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- Orungal
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- R 51211
- SUBA Itraconazole
- Sempera
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- Spherazole IR
- Sporal
- Sporamelt
- Sporanox
- Sporanox IV
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- Traconal
- Triasporin
- cis-Itraconazole
- rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
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Encontrado 24 productos.
Itraconazole, 98%
CAS:Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine
Fórmula:C35H38Cl2N8O4Pureza:98%Forma y color:White to cream, Powder or crystalline powderPeso molecular:705.64ITRACONAZOLE CRS
CAS:ITRACONAZOLE CRSFórmula:C35H38Cl2N8O4Forma y color:White. Powder.Peso molecular:705.6334Itraconazole
CAS:ItraconazoleFórmula:C35H38CI2N8O4Pureza:99.7%Forma y color:White To Off-WhitePeso molecular:900.11055Itraconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C35H38ClN8O4Forma y color:White PowderPeso molecular:669.27045Ref: IN-DA003R60
1g30,00€5g50,00€10g77,00€1kgA consultar25g133,00€50g161,00€100g297,00€25mg24,00€500g503,00€100mg25,00€250mg25,00€Itraconazole
CAS:Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.Fórmula:C35H38Cl2N8O4Pureza:98% - 99.90%Forma y color:Off-White Crystalline SolidPeso molecular:705.63Itraconazole Impurity 5
CAS:Fórmula:C34H35Cl2N8O4·ClForma y color:Yellow SolidPeso molecular:690.61 35.45Itraconazole N-Oxide
CAS:Fórmula:C35H38Cl2N8O5Forma y color:White To Off-White SolidPeso molecular:721.64Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:99.0 - 101.0 % (dried basis)Forma y color:White or almost white powderPeso molecular:705.63Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:705.64Itraconazole-d9
CAS:Producto controladoApplications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),Fórmula:C35H29D9Cl2N8O4Forma y color:Off-White To BeigePeso molecular:714.69Itraconazole
CAS:Producto controladoApplications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);Fórmula:C35H38Cl2N8O4Forma y color:White To Off-WhitePeso molecular:705.63Itraconazole - Bio-X ™
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia.Fórmula:C35H38Cl2N8O4Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:705.63 g/molItraconazole
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.Fórmula:C35H38Cl2N8O4Pureza:Min. 98.5 Area-%Forma y color:White PowderPeso molecular:705.63 g/mol
