CAS 850140-72-6

Afatinib

Descripción:

Afatinib es un inhibidor de la tirosina quinasa de moléculas pequeñas utilizado principalmente en el tratamiento del cáncer de pulmón de células no pequeñas (CPCNP) que presenta mutaciones específicas en el gen del receptor del factor de crecimiento epidérmico (EGFR). Se caracteriza por su capacidad para unirse de forma irreversible al EGFR y a otros miembros de la familia de receptores ErbB, inhibiendo así sus vías de señalización que promueven la proliferación y supervivencia celular. La fórmula química de Afatinib es C24H25ClFN5O3, y presenta una estructura compleja que incluye un anillo fenílico sustituido por cloro y un moiety de piperazina. Afatinib se administra por vía oral y es conocido por sus posibles efectos secundarios, que pueden incluir diarrea, erupción cutánea y estomatitis. Su farmacocinética indica que tiene una vida media relativamente larga, lo que permite una dosificación una vez al día. El fármaco se clasifica como un agente antineoplásico y forma parte de la terapia dirigida, representando un avance significativo en la medicina personalizada para pacientes con perfiles genéticos específicos en sus tumores.

Fórmula: C₂₄H₂₅ClFN₅O₃

InChI: InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+

Clave InChI: InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Sinónimos:

• (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
• (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
• (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
• 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
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Afatinib

CAS: 850140-72-6

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: >97.0%(HPLC)(N)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 485.94

Ref: 3B-A2870

Afatinib (BIBW 2992)

CAS: 850140-72-6

Fórmula: C₂₄H₂₅ClFN₅O₃

Forma y color: White To Off-White Solid

Peso molecular: 485.95

Ref: 4Z-A-111001

Afatinib

CAS: 850140-72-6

Afatinib

Pureza: ≥95%

Peso molecular: 485.94g/mol

Ref: 54-BUP15589

Afatinib

CAS: 850140-72-6

Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: 98.56% - 99.9%

Forma y color: Off-White Solid

Peso molecular: 485.94

Ref: TM-T21312

Afatinib-d4

CAS: 850140-72-6

Fórmula: C₂₄H₂₁ClFN₅O₃D₄

Peso molecular: 489.97

Ref: 4Z-A-111002

Afatinib

CAS: 850140-72-6

Afatinib

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: By hplc: >99% (Typical Value in Batch COA)

Forma y color: white to off-white solid

Peso molecular: 485.94g/mol

Ref: 54-BIFK0010

Afatinib, Free Base

CAS: 850140-72-6

Pureza: 99.0%

Forma y color: Solid, No data available.

Peso molecular: 485.94000244140625

Ref: 10-F050665

Afatinib

CAS: 850140-72-6

Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)

Fórmula: C₂₄H₂₅ClFN₅O₃

Forma y color: Neat

Peso molecular: 485.94

Ref: TR-A355300

Afatinib

CAS: 850140-72-6

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 485.94 g/mol

Ref: 3D-FC17230

Afatinib - Bio-X ™

CAS: 850140-72-6

Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 485.94 g/mol

Ref: 3D-BA164141

Afatinib-d4

Producto controlado

CAS: 850140-72-6

Fórmula: C₂₄D₄H₂₁ClFN₅O₃

Forma y color: Neat

Peso molecular: 489.963

Ref: TR-A355302