CAS 863918-55-2

5H-Pirano[3,2-d]tiazol-6,7-diol, 3a,6,7,7a-tetrahidro-5-(hidroximetil)-2-propil-, (3aR,5R,6S,7R,7aR)-

Descripción:

5H-Pirano[3,2-d]tiazol-6,7-diol, 3a,6,7,7a-tetrahidro-5-(hidroximetil)-2-propilo-, con número CAS 863918-55-2, es un compuesto orgánico complejo caracterizado por su estructura bicíclica única que incorpora tanto un moiety de pirano como de tiazol. Este compuesto presenta múltiples grupos funcionales, incluyendo grupos hidroximetilo y dioles, que contribuyen a su potencial reactividad y solubilidad en varios disolventes. La estereoquímica indicada por la designación (3aR,5R,6S,7R,7aR) sugiere disposiciones espaciales específicas de sus átomos, que pueden influir en su actividad biológica e interacciones con otras moléculas. Tales compuestos pueden exhibir propiedades farmacológicas interesantes, lo que los hace de interés en la química medicinal. La presencia del grupo propilo mejora sus características hidrofóbicas, afectando potencialmente su biodisponibilidad e interacción con membranas biológicas. En general, la complejidad estructural y la diversidad funcional de este compuesto sugieren aplicaciones potenciales en el desarrollo de fármacos y otros campos de la investigación química.

Fórmula: C₁₀H₁₇NO₄S

Sinónimos:

• 5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, (3aR,5R,6S,7R,7aR)-

NButGT - Bio-X ™

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.  Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₇NO₄S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 247.31 g/mol

Ref: 3D-BN300156

NButGT

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.

Fórmula: C₁₀H₁₇NO₄S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 247.31 g/mol

Ref: 3D-NN180123