CAS 86408-36-8

clorhidrato de polimixina B nonapéptido

Descripción:

clorhidrato de polimixina B nonapéptido es un derivado sintético de la polimixina B, que es un antibiótico derivado de la bacteria Bacillus polymyxa. Este compuesto se caracteriza por su estructura, que consiste en un péptido cíclico con una cola hidrofóbica, lo que contribuye a su capacidad para interrumpir las membranas celulares bacterianas. Exhibe una potente actividad antimicrobiana, particularmente contra bacterias Gram-negativas, lo que lo hace valioso en entornos clínicos para tratar infecciones causadas por organismos multirresistentes. La forma de clorhidrato mejora su solubilidad en soluciones acuosas, facilitando su uso en diversas formulaciones farmacéuticas. clorhidrato de polimixina B nonapéptido también se destaca por su menor toxicidad en comparación con otras polimixinas, lo que es ventajoso para aplicaciones terapéuticas. Además, se ha estudiado su posible uso en terapias combinadas para mejorar la eficacia de otros antibióticos. Su mecanismo de acción implica principalmente la unión a los lipopolisacáridos en la membrana externa bacteriana, lo que conduce a la lisis celular. En general, este compuesto representa una herramienta significativa en la lucha contra infecciones resistentes a los antibióticos.

Fórmula: C₄₃H₇₄N₁₄O₁₁

InChI: InChI=1/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)/t23-,24-,26+,27+,28+,29+,30+,31+,32-,33+,34+/m1/s1

Sinónimos:

• Polymyxin B nonapeptide
• Pmbn
• Polymyxin B cyclononapeptide
• Polymyxin B1, 1-de(N2-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoic acid)-
• N-[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]-L-threoninamide

(2S,3R)-2-amino-N-[(1S)-3-amino-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-3-hydroxy-butanamide

CAS: 86408-36-8

Fórmula: C₄₃H₇₄N₁₄O₁₁

Pureza: 98%

Peso molecular: 963.1349

Ref: IN-DA004XCE

Polymyxin B nonapeptide

CAS: 86408-36-8

Polymyxin B nonapeptide boosts hydrophobic antibiotic uptake in Gram-negative bacteria by enhancing membrane permeability.

Fórmula: C₄₃H₇₄N₁₄O₁₁

Pureza: 98%

Forma y color: Solid

Peso molecular: 963.13

Ref: TM-TP1341

Polymyxin B nonapeptide hydrochloride

CAS: 86408-36-8

Polymyxin B nonapeptide hydrochloride is a potent antibiotic compound derived from the bacterium *Bacillus polymyxa*. As a cationic polypeptide, it exhibits its antibacterial activity by interacting with the lipopolysaccharides and phospholipids in the bacterial cell membrane, leading to increased permeability and ultimately causing cell lysis. The compound is specifically effective against a broad range of Gram-negative bacteria, making it crucial in studying antibiotic resistance mechanisms.

Fórmula: C₄₃H₇₄N₁₄O₁₁•(HCl)x

Pureza: Min. 95%

Peso molecular: 963.14 g/mol

Ref: 3D-AP182838

Polymyxin B Nonapeptide

Producto controlado

CAS: 86408-36-8

Fórmula: C₄₃H₇₄N₁₄O₁₁

Forma y color: Neat

Peso molecular: 963.135

Ref: TR-P689398

Polymyxin B nonapeptide

CAS: 86408-36-8

Polymyxin B nonapeptide is a polymyxin antibiotic that is effective against Gram-negative bacteria. It has been shown to inhibit the growth of wild-type strains of Escherichia coli and Salmonella enterica in laboratory tests, as well as cancer tissues. Polymyxin B nonapeptide binds to the il-2 receptor on human cells and inhibits the activation of interleukin 2, which is an important immune response regulator. The drug also has biocompatible properties and does not cause any significant physiological effects or alterations in redox potentials when injected into humans. This antibiotic has a phase transition temperature of 56°C and can be used for treating tissue infections caused by bacteria with a high resistance to antibiotics.

Fórmula: C₄₃H₇₄N₁₄O₁₁

Pureza: Min. 95%

Peso molecular: 963.1 g/mol

Ref: 3D-LDA40836