CAS 87096-84-2

neuromedina B

Descripción:

neuromedina B es un neuropeptido que desempeña un papel significativo en varios procesos fisiológicos, incluida la regulación de la contracción del músculo liso y la modulación de las funciones neuroendocrinas. Está compuesto por una secuencia de aminoácidos y se clasifica como un miembro de la familia de neuromedinas, que están involucradas en la neurotransmisión y la señalización dentro del sistema nervioso central. neuromedina B actúa principalmente a través de receptores específicos, influyendo en procesos como la regulación del apetito, la respuesta al estrés y las funciones reproductivas. Se sabe que el péptido está involucrado en la fisiopatología de ciertas condiciones, incluidas la obesidad y los trastornos de ansiedad. Su estructura típicamente incluye una amidación en el extremo C-terminal, que es crucial para su actividad biológica. neuromedina B se sintetiza en varios tejidos, incluidos el cerebro y el tracto gastrointestinal, y sus efectos se median a través de interacciones con receptores acoplados a proteínas G. La investigación continúa explorando sus posibles aplicaciones terapéuticas, particularmente en el contexto de trastornos metabólicos y neuropsiquiátricos.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

InChI: InChI=1/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29+,35-,36-,37?,38-,39-,40-,44-/m0/s1

Sinónimos:

• H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
• (2S)-2-[(2-aminoacetyl)amino]-N-[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[2-[[(1S)-2-[[1-benzyl-2-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]amino]-2-oxo-ethyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]butanediamide

Neuromedin B

CAS: 87096-84-2

For cellular and molecular biology applications

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Forma y color: Lyophilized powder

Peso molecular: 1132.3

Ref: 02-J66286

Neuromedin B

CAS: 87096-84-2

NMB, a bombesin-linke peptide, binds to the bombesin receptors BRS1-4. NMB is expressed in the pituitary, brain, pancreas, adrenal and gastrointestinal tract. Its expression in adipose tissue appears to be regulated by changes in energy balance. NMB could inhibit food intake and modulates stress-related behavior.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: 97.4%

Forma y color: White Powder

Peso molecular: 1132.31

Ref: 01-4020211

Neuromedin B

CAS: 87096-84-2

Neuromedin B

Pureza: ≥98%

Peso molecular: 1132.29g/mol

Ref: 54-BUP01758

Neuromedin B

CAS: 87096-84-2

Neuromedin B, a mammalian peptide related to bombesin, is found in the CNS and GI tract, originally purified from pig spinal cords.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: 99.39%

Forma y color: Solid

Peso molecular: 1132.29

Ref: TM-TP1442

Neuromedin B (porcine)

CAS: 87096-84-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Peso molecular: 1,132.3 g/mol

Ref: 3D-PP50044

Neuromedin C (Human, Porcine, Canine)

CAS: 87096-84-2

Neuromedin C (NMC) is a peptide that belongs to the family of neuromedin and is a potent activator of ion channels. It has been shown to be a ligand for opioid receptors, which may be due to its ability to inhibit the release of neurotransmitters such as acetylcholine and noradrenaline. Neuromedin C has also been shown to inhibit the binding of morphine-6 beta-glucuronide in rat brain synaptosomes. In addition, NMC has been reported as an inhibitor of cell proliferation and induce apoptosis in various cancer cells including colon and prostate cancers.

Fórmula: C₅₀H₇₃N₁₇O₁₁S

Pureza: Min. 95%

Peso molecular: 1,120.3 g/mol

Ref: 3D-PNM-4153-V

Neuromedin B (Human, Porcine, Rat)

CAS: 87096-84-2

Neuromedin B is a neuropeptide that has been shown to activate the TRPC ion channels in mammalian cells. It also has been shown to bind to receptors and have a potent effect on cell biology, as well as being used as a research tool for studying protein interactions. Neuromedin B is found in humans, pigs, and rats, where it is expressed primarily in the brain and gastrointestinal tract. This peptide has been shown to be an inhibitor of some types of ion channels.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: Min. 95%

Peso molecular: 1,132.3 g/mol

Ref: 3D-PNM-4152-V

Neuromedin B trifluoroacetate salt

CAS: 87096-84-2

Neuromedin B is a peptide hormone that is produced by the hypothalamus and regulates many physiological processes such as energy metabolism, appetite, and sleep. Neuromedin B is a member of the family of guanine nucleotide-binding proteins (G proteins) that bind to G protein-coupled receptors on the surface of cells. It has been shown to stimulate calcium release from intracellular stores in response to an increase in cytosolic Ca2+. Neuromedin B has been shown to have anti-inflammatory effects on infectious diseases such as meningitis, sepsis, and tuberculosis, which may be due to its ability to inhibit neutrophil migration. Neuromedin B also stimulates hippocampal formation activity in rats during the rotarod test, which may be due to its effects on dopamine release.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: Min. 95%

Peso molecular: 1,132.3 g/mol

Ref: 3D-FN108954