CAS 872728-81-9

Mesilato de etexilato de dabigatrán

Descripción:

Mesilato de etexilato de dabigatrán es un medicamento anticoagulante oral que se utiliza principalmente para la prevención y el tratamiento de trastornos tromboembólicos, como la fibrilación auricular y la trombosis venosa profunda. Es un profármaco que se convierte en el cuerpo en su forma activa, dabigatrán, que inhibe directamente la trombina, una enzima clave en la cascada de coagulación. Esta inhibición previene la conversión de fibrinógeno a fibrina, reduciendo así la formación de coágulos. La sustancia se caracteriza por su alta biodisponibilidad y rápido inicio de acción, lo que la hace efectiva para el manejo agudo y crónico de trastornos de coagulación. Mesilato de etexilato de dabigatrán se administra típicamente en forma de cápsula y es conocida por su farmacocinética predecible, lo que permite una dosificación fija sin monitoreo rutinario de los parámetros de coagulación. Es importante señalar que, al igual que otros anticoagulantes, conlleva un riesgo de hemorragia, y su uso puede estar contraindicado en ciertas poblaciones, como aquellas con insuficiencia renal severa. En general, Mesilato de etexilato de dabigatrán representa un avance significativo en la terapia anticoagulante.

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

InChI: InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)

Clave InChI: InChIKey=XETBXHPXHHOLOE-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4.S(C)(=O)(=O)O

Sinónimos:

• Bibr 1048Ms
• Dabigatran Etexilate Mesilate
• Dabigatran Etexilate Methanesulfonate
• Dabigatran etexilate mesylate
• N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat
• Pradaxa
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, monomethanesulfonate

DABIGATRAN ETEXILATE MESILATE CRS

CAS: 872728-81-9

DABIGATRAN ETEXILATE MESILATE CRS

Ref: 41-Y0002393

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

Forma y color: White Off-White Yellow Powder

Peso molecular: 723.30503

Ref: 45-1162239

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Fórmula: C₃₅H₄₅N₇O₈S

Pureza: 98%

Forma y color: Solid

Peso molecular: 723.8389

Ref: IN-DA00391G

Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate Methanesulfonate

CAS: 872728-81-9

Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate Methanesulfonate

Pureza: 98%

Peso molecular: 723.84g/mol

Ref: 54-OR1029511

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Dabigatran Etexilate Mesylate

Pureza: ≥98%

Peso molecular: 723.84g/mol

Ref: 54-BUP17140

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 723.85

Ref: 3B-D6198

Dabigatran Etexilate Mesilate

Producto controlado

CAS: 872728-81-9

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

Forma y color: Neat

Peso molecular: 723.84

Ref: 86-MM3522.00

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

Pureza: 99.91%

Forma y color: Solid

Peso molecular: 723.84

Ref: TM-T5133

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Fórmula: C₃₄H₄₁N₇O₅CH₄O₃S

Peso molecular: 627.7 : 96.1

Ref: ST-EA-CP-D5074

Dabigatran Etexilate Mesylate

Producto controlado

CAS: 872728-81-9

Applications Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Fórmula: C₃₄H₄₁N₇O₅·CH₄O₃S

Forma y color: Light Yellow

Peso molecular: 723.84

Ref: TR-D100150

Dabigatran etexilate mesylate

CAS: 872728-81-9

Dabigatran etexilate mesylate is an anticoagulant that is a prodrug of dabigatran, which is not active in the body. It is a synthetic molecule that has been designed to be rapidly converted into dabigatran by esterases in the blood plasma. Dabigatran etexilate mesylate has been shown to have a high bioavailability and low clearance rate, as well as good oral absorption and stability. The drug can be used for people with impaired liver function who are being treated with warfarin or heparin, without any change in dosage requirements. The antidote for dabigatran etexilate mesylate is idarucizumab, which binds to dabigatran in the bloodstream and prevents its binding to thrombin receptors on the surface of blood cells.

Fórmula: C₃₅H₄₅N₇O₈S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 723.84 g/mol

Ref: 3D-FD20773