CAS 873857-62-6

Fidaxomicina

Descripción:

Fidaxomicina es un antibiótico macrólido utilizado principalmente para el tratamiento de infecciones por Clostridium difficile. Se caracteriza por su mecanismo de acción único, que implica la inhibición de la ARN polimerasa bacteriana, evitando así la síntesis de proteínas bacterianas. Esta inhibición selectiva permite que Fidaxomicina apunte eficazmente a C. difficile mientras preserva la flora intestinal normal, que es crucial para mantener la salud intestinal. El compuesto se absorbe mal de forma sistémica, lo que lleva a altas concentraciones en el tracto gastrointestinal, lo que mejora su eficacia contra infecciones intestinales. Fidaxomicina se administra típicamente por vía oral y es conocido por su perfil de seguridad favorable, con menos efectos secundarios gastrointestinales en comparación con otros antibióticos. Su estructura química presenta un complejo anillo de lactona macrocíclica, que contribuye a sus propiedades antibacterianas. El fármaco se prefiere a menudo en casos de infecciones recurrentes por C. difficile debido a su capacidad para reducir las tasas de recurrencia. En general, Fidaxomicina representa un avance significativo en el tratamiento de la diarrea asociada a antibióticos causada por C. difficile, ofreciendo un enfoque dirigido con una mínima interrupción del microbioma intestinal.

Fórmula: C₅₂H₇₄Cl₂O₁₈

InChI: InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1

Clave InChI: InChIKey=ZVGNESXIJDCBKN-UUEYKCAUSA-N

SMILES: C(O[C@H]1[C@H](O)[C@H](OC)[C@H](OC\C=2\C(=O)O[C@]([C@@H](C)O)(C/C=C(\C)/C=C(\C)/[C@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)[C@@H](CC)/C=C(\C)/[C@@H](O)C\C=C\C2)[H])O[C@@H]1C)(=O)C4=C(CC)C(Cl)=C(O)C(Cl)=C4O

Sinónimos:

• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
• Clostomicin B₁
• Dificid
• Dificlir
• Fidaxomycin
• Lipiarmicin
• Lipiarmycin
• Lipiarmycin A 3
• Opt-80
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
• Par 01
• Par-101
• R-Tiacumicin B
• Tiacumicin B
• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 1,058.05

Ref: 3B-F1216

Fidaxomycin; Lipiarmycin A3; Tiacumicin B; Chlostomicin B1;

CAS: 873857-62-6

Fórmula: C₅₂H₇₄CL₂O₁₈

Pureza: 98.89%

Forma y color: Off white. Powder

Peso molecular: 1056.0

Ref: 8R-CL0228

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Fórmula: C₅₂H₇₄Cl₂O₁₇

Pureza: By hplc: 98.48% (Typical Value in Batch COA)

Forma y color: white to off-white powder

Peso molecular: 1,042.04g/mol

Ref: 54-BIW4203

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Pureza: ≥98%

Peso molecular: 1058.04g/mol

Ref: 54-BUP15040

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: ≥ 97.0%

Forma y color: White to off-white powder

Peso molecular: 1058.0

Ref: 7W-GA3227

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Forma y color: White To Off-White Solid

Peso molecular: 1058.05

Ref: 4Z-F-076001

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults.

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: 99.76% - 99.82%

Forma y color: Solid

Peso molecular: 1058.04

Ref: TM-T6194

Fidaxomicin

CAS: 873857-62-6

Applications Fidaxomicin is a nonabsorbed macrocyclic antibiotic, and is the first antimicrobial to be approved by the FDA for the treatment of Clostridium difficile infection (CDI) in 20 years. Fidaxomicin works by inhibiting sporulation by CDI, sustaining clinical response and reducing recurrences of this pathogen.
References Babakhani, F., et al.: Clin. Infect. Dis., 55, S162 (2012); Venugopal, A., et al.: Clin. Infect. Dis., 54, 568 (2012)

Fórmula: C₅₂H₇₄Cl₂O₁₈

Forma y color: Neat

Peso molecular: 1058.04

Ref: TR-F335400

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin is a macrocyclic antibiotic with action on bacterial RNA polymerase and is used for treating Clostridium difficile infections.

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 1,058.04 g/mol

Ref: 3D-AF31015