CAS 88847-89-6

8-Hidroxi-2'-desoxiguanosina

Descripción:

8-Hidroxi-2'-desoxiguanosina (8-OHdG) es un nucleósido modificado que sirve como biomarcador para el estrés oxidativo y el daño en el ADN. Se forma cuando las especies reactivas de oxígeno (ROS) interactúan con la desoxiguanosina, lo que lleva a la oxidación de la base de guanina. Este compuesto se caracteriza por la presencia de un grupo hidroxilo en la posición 8 del anillo de guanina, lo que lo distingue de su contraparte no modificada. El 8-OHdG es soluble en agua y exhibe una tendencia a formar aductos estables con el ADN, lo que puede llevar a efectos mutagénicos si no se repara. Su presencia en muestras biológicas, como la orina y los tejidos, se mide a menudo para evaluar el daño oxidativo y tiene implicaciones en diversas enfermedades, incluyendo el cáncer y los trastornos neurodegenerativos. Se emplean comúnmente técnicas analíticas como la cromatografía líquida de alta resolución (HPLC) y la espectrometría de masas para cuantificar los niveles de 8-OHdG. En general, 8-Hidroxi-2'-desoxiguanosina es un marcador significativo en el estudio del estrés oxidativo y su papel en el daño celular y la progresión de enfermedades.

Fórmula: C₁₀H₁₃N₅O₅

InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1

Clave InChI: InChIKey=HCAJQHYUCKICQH-VPENINKCSA-N

SMILES: O=C1N(C2=C(N1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)C3

Sinónimos:

• 2'-Deoxy-8-Oxoguanosine
• 2′-Deoxy-7,8-dihydro-8-oxoguanosine
• 7,8-Dihydro-2'-deoxy-8-oxoguanosine
• 7,8-Dihydro-8-oxo-2′-deoxyguanosine
• 7,8-Dihydro-8-oxodeoxyguanosine
• 8-Hydroxydeoxyguanosine
• 8-Oxo-2'-deoxyguanine
• 8-Oxo-2′-deoxyguanosine
• 8-Oxo-7,8-dihydro-2'-deoxyguanosine
• 8-Oxo-7,8-dihydrodeoxyguanosine
• 8-Oxo-7-hydrodeoxyguanosine
• 8-Oxo-dG
• 8-Oxodeoxyguanosine
• Ccris 8239
• Guanosine, 2'-deoxy-7,8-dihydro-8-oxo-
• Guanosine, 7,8-dihydro-2'-deoxy-8-oxo-
• 8-Hydroxy-2'-deoxyguanosine

8-OXO-2'-DEOXYGUANOSINE

CAS: 88847-89-6

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 95%

Forma y color: Solid

Peso molecular: 283.2407

Ref: IN-DA003GJ0

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine

Pureza: ≥95%

Peso molecular: 283.24g/mol

Ref: 54-BUP04565

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine

Pureza: 95%

Peso molecular: 283.24g/mol

Ref: 54-OR1010294

2''-Deoxy-8-oxoguanosine

CAS: 88847-89-6

Fórmula: C₁₀H₁₃N₅O₅

Pureza: ≥ 95.0%

Forma y color: White to off-white powder or crystalline powder

Peso molecular: 283.24

Ref: 7W-GN0582

8-Hydroxy-2'-Deoxyguanosine

CAS: 88847-89-6

Fórmula: C₁₀H₁₃N₅O₅

Peso molecular: 283.24

Ref: 4Z-G-2432

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases.

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 99.10%

Forma y color: White Solid

Peso molecular: 283.24

Ref: TM-T8343

8-Oxo-2’-deoxyguanosine-13C,15N2

Producto controlado

CAS: 88847-89-6

Applications A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
References Ueda, T., et al.: Chem. Pharm. Bull., 26, 2122 (1978), Jiang, F., et al.: Nature, 183, 382 (1996),

Fórmula: C₉₁₃CH₁₃N₃₁₅N₂O₅

Forma y color: Neat

Peso molecular: 286.22

Ref: TR-O850252

8-Oxo-2’-deoxyguanosine

Producto controlado

CAS: 88847-89-6

Applications A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
References Ueda, T., et al.: Chem. Pharm. Bull., 26, 2122 (1978), Jiang, F., et al.: Nature, 183, 382 (1996),

Fórmula: C₁₀H₁₃N₅O₅

Forma y color: White To Beige

Peso molecular: 283.24

Ref: TR-O850250

8-Hydroxy-2′-deoxyguanosine

CAS: 88847-89-6

Fórmula: C₁₀H₁₃N₅O₅

Peso molecular: 283.24

Ref: ST-EA-CP-A88043

2'-Deoxy-8-oxoguanosine

CAS: 88847-89-6

2'-Deoxy-8-oxoguanosine (8-OHdG) is a product of oxidative DNA damage. The presence of 8-OHdG in urine has been used to detect and measure the degree of oxidative DNA damage in humans and animals, which may be linked to cancer and aging. When 8-OHdG is excreted into urine, it can react with other molecules such as protein or inorganic phosphorus, causing more oxidative DNA damage. 2'-Deoxy-8-oxoguanosine has also been shown to cause cell toxicity by damaging the cell's squamous epithelium, leading to cancer.For the 15N5 labelled version please check ND09970.

Fórmula: C₁₀H₁₃N₅O₅

Pureza: Min. 95 Area-%

Forma y color: White Powder

Peso molecular: 283.25 g/mol

Ref: 3D-ND06344

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione

CAS: 88847-89-6

Fórmula: C₁₀H₁₃N₅O₅

Pureza: 95%

Forma y color: Solid

Peso molecular: 283.244

Ref: 10-F460639