CAS 88937-61-5

Z-Arg-Arg-AMC

Descripción:

Z-Arg-Arg-AMC, también conocido por su número CAS 88937-61-5, es un sustrato peptídico sintético comúnmente utilizado en investigaciones bioquímicas, particularmente en estudios que involucran proteasas y actividad enzimática. Este compuesto presenta un grupo protector Z (benzyloxycarbonilo) en el residuo de arginina N-terminal, lo que mejora su estabilidad y solubilidad. La presencia de dos residuos de arginina en su estructura lo convierte en un sustrato para varias enzimas, particularmente aquellas que escinden en aminoácidos básicos. El moiety AMC (7-amino-4-metilcumarina) sirve como un reportero fluorescente, permitiendo la cuantificación de la actividad enzimática a través de mediciones de fluorescencia. Z-Arg-Arg-AMC se utiliza a menudo en ensayos para estudiar la actividad proteolítica, proporcionando información sobre la cinética enzimática y la especificidad del sustrato. Sus características incluyen alta solubilidad en soluciones acuosas, estabilidad bajo condiciones fisiológicas y la capacidad de producir una señal fluorescente medible tras la escisión, lo que lo convierte en una herramienta valiosa en la investigación de biología molecular y bioquímica.

Fórmula: C₃₀H₃₉N₉O₆

InChI: InChI=1/C30H39N9O6/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-22(9-5-13-35-28(31)32)26(41)39-27(42)23(10-6-14-36-29(33)34)38-30(43)44-17-19-7-3-2-4-8-19/h2-4,7-8,11-12,15-16,22-23,37H,5-6,9-10,13-14,17H2,1H3,(H,38,43)(H4,31,32,35)(H4,33,34,36)(H,39,41,42)/t22-,23-/m0/s1

Clave InChI: InChIKey=DLELKZFCVLJXKZ-GOTSBHOMSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(OCC3=CC=CC=C3)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1

Sinónimos:

• Z-Arg-Arg-AMC
• Benzyloxycarbonyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
• 386: PN: US20220178935 SEQID: 1064 claimed sequence
• N2-[(Phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
• L-Argininamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-Arg-Arg-NHMec
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-ARG-ARG-MCA HYDROCHLORIDE
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]carbamate
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-RR-AMC, an excellent, specific substrate for cathepsin B, an enzyme found in secretory vesicles. Cathepsin B has been identified as a β-secretase, as such it is involved in β-amyloid production. Z-RR-AMC is a convenient fluorogenic substrate for stem bromelain, as it is scarcely affected by fruit bromelain.

Fórmula: C₃₀H₃₉N₉O₆

Pureza: > 98%

Forma y color: White Powder

Peso molecular: 621.7

Ref: 01-4004789

Z-Arg-Arg-AMC hydrochloride salt

CAS: 88937-61-5

Z-Arg-Arg-AMC hydrochloride salt is a versatile compound that acts as a catalyst and forms strong hydrogen bonds. It exhibits proteolytic activity and has been found to be effective in breaking down proteins. In addition, Z-Arg-Arg-AMC hydrochloride salt has been shown to possess neuroprotective properties, making it a potential candidate for the treatment of neurological disorders. It also demonstrates anthelmintic activity, which means it can be used to combat parasitic worm infections. Furthermore, this compound has antioxidant activity and can help reduce lipid peroxidation, protecting cells from oxidative damage. With its diverse range of characteristics, Z-Arg-Arg-AMC hydrochloride salt holds great promise in various research fields such as biochemistry and medicine.

Fórmula: C₃₀H₃₉N₉O₆·xHCl

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 621.69 g/mol

Ref: 3D-FA110491

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.

Fórmula: C₃₀H₃₉N₉O₆

Pureza: Min. 95%

Peso molecular: 621.69 g/mol

Ref: 3D-MRR-3123-V