CAS 89-25-8

Edaravona

Descripción:

Edaravona, con el número CAS 89-25-8, es un compuesto sintético reconocido principalmente por sus propiedades neuroprotectoras. Se clasifica como un captador de radicales libres, lo que significa que puede neutralizar radicales libres dañinos en el cuerpo, reduciendo así el estrés oxidativo. Esta característica lo hace particularmente relevante en el tratamiento de enfermedades neurodegenerativas, como la esclerosis lateral amiotrófica (ELA) y el accidente cerebrovascular isquémico agudo. Edaravona se presenta típicamente como un líquido incoloro a amarillo pálido y es soluble en agua, lo que facilita su administración en entornos clínicos. El compuesto tiene un peso molecular relativamente bajo y exhibe un nivel moderado de lipofilia, lo que le permite penetrar eficazmente en las membranas biológicas. Su mecanismo de acción implica la inhibición de la peroxidación lipídica y la protección de las células neuronales del daño oxidativo. Edaravona ha sido estudiado extensamente por su potencial terapéutico, y aunque generalmente es bien tolerado, puede tener efectos secundarios que requieren monitoreo durante el tratamiento.

Fórmula: C₁₀H₁₀N₂O

InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

Clave InChI: InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

SMILES: O=C1N(N=C(C)C1)C2=CC=CC=C2

Sinónimos:

• 1,3,5-Pmp
• 1-Fenil-3-Metil-5-Pirazolona
• 1-Phenyl-3-Methyl-5-Prazalone
• 1-Phenyl-3-Methyl-5-Pyrazole
• 1-Phenyl-3-Methyl-5-Pyrazolone
• 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
• 1-Phenyl-3-methyl-2-pyrazolin-5-one
• 1-Phenyl-3-methyl-5-oxopyrazole
• 1-Phenyl-3-methyl-5-pyrazolinone
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-On
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-One
• 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazole-3-one
• 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
• 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
• 3-Methyl-1-phenyl-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-2-pyrazoline-5-one
• 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one
• 3-Methyl-1-phenyl-5-pyrazolon
• 3-Methyl-1-phenyl-5-pyrazolone
• 3-Methyl-1-phenylpyrazol-5(4H)-one
• 3-Methyl-1-phenylpyrazol-5-one
• 3-Methyl-1-phenylpyrazole-5-one
• 3-Methyl-1-phenylpyrazolin-5-one
• 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
• 4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one
• 5-Methyl-2-phenylpyrazol-3-one
• Developer Z
• Edarabone
• Edaravon
• Edaravone
• Edvaradone
• Mci-186
• Methylphenylpyrazolone
• Nci-C 03952
• Norantipyrine
• Norphenazone
• Nsc 12
• Nsc 26139
• Nsc 2629
• PMP
• Phenylmethyl pyrazolone
• Pyrazolin(2)-5-One, 3-Methyl-1-Phenyl-
• Radicava
• Radicut
• C.I. Developer 1

3-Methyl-1-phenyl-5-pyrazolone

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 174.20

Ref: 3B-M0687

3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%

CAS: 89-25-8

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original A

Fórmula: C₁₀H₁₀N₂O

Pureza: 98+%

Forma y color: Pale cream to cream to yellow to pale brown, Powder

Peso molecular: 174.20

Ref: 02-A11161

PHENAZONE IMPURITY A CRS

CAS: 89-25-8

PHENAZONE IMPURITY A CRS

Ref: 41-Y0001138

Antipyrine Related Compound A (3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one)

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Fórmula: C₁₀H₁₀N₂O

Forma y color: White Pale Yellow Powder

Peso molecular: 174.07931

Ref: 45-1040016

Edaravone

CAS: 89-25-8

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Fórmula: C₁₀H₁₀N₂O

Pureza: 99.44% - >99.99%

Forma y color: Pale Yellow Solid Solid Particulate/Powder

Peso molecular: 174.20

Ref: TM-T0407

Edaravone

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Pureza: 95%

Forma y color: Solid

Peso molecular: 174.1992

Ref: IN-DA0087X2

Edaravone

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Forma y color: White To Off-White Solid

Peso molecular: 174.20

Ref: 4Z-E-531

Edaravone

CAS: 89-25-8

Edaravone

Pureza: ≥98%

Peso molecular: 174.2g/mol

Ref: 54-BUP18301

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

1-Phenyl-3-methyl-5-pyrazolone

Fórmula: C₁₀H₁₀N₂O

Pureza: 98%

Forma y color: yellow crystalline powder

Peso molecular: 174.20g/mol

Ref: 54-BIP1205

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Pureza: ≥ 98.0%

Forma y color: White to yellow to brown powder or crystals

Peso molecular: 174.20

Ref: 7W-GK3502

5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone)

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Forma y color: Neat

Peso molecular: 174.20

Ref: 86-MM0036.01

Edaravone

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Forma y color: Neat

Peso molecular: 174.20

Ref: 04-C13105000

3-​Methyl-​1-​phenyl-​2-​pyrazolin-​5-​one(Edaravone)

Producto controlado

CAS: 89-25-8

Impurity Phenazone EP Impurity A
Applications Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
References Reeta KH et al. Eur J Neurosci. 2017 Feb 15Masuda T et al. Oxid Med Cell Longev. 2017;2017:9208489Zhang DY et al. J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):51-56Criswell LA et al. Am J Med. 2002 Apr 15;112(6):465-71.

Fórmula: C₁₀H₁₀N₂O

Forma y color: Neat

Peso molecular: 174.20

Ref: TR-E335000

Antipyrine USP Related Compound A

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Peso molecular: 174.2

Ref: ST-EA-CP-A104005

3-Methyl-1-phenyl-2-pyrazoline-5-one

CAS: 89-25-8

Fórmula: C₁₀H₁₀N₂O

Pureza: 95%

Forma y color: Solid

Peso molecular: 174.203

Ref: 10-F038216

Edaravone

CAS: 89-25-8

Edaravone is a drug that belongs to the class of radical scavengers and has been shown to be effective in reducing neuronal death by blocking the mitochondrial permeability transition pore. It also protects against oxidative injury by inhibiting lipid peroxidation, protein nitration, and DNA damage. Edaravone has been shown to be effective in treating bowel disease and possibly other inflammatory diseases such as sepsis. Edaravone is injected intravenously and can be used as an injection solution with dextran sulfate due to its low solubility in water. Edaravone binds reversibly to the toll-like receptor 4 (TLR4) and inhibits TLR4-mediated signaling pathways, which may lead to a reduction of inflammation.

Fórmula: C₁₀H₁₀N₂O

Pureza: Min. 98%

Forma y color: Powder

Peso molecular: 174.2 g/mol

Ref: 3D-FE22642

Edaravone

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Fórmula: C₁₀H₁₀N₂O

Peso molecular: 174.07931

Ref: 45-1231900