CAS 89226-75-5

Dihidrocloruro de manidipino

Descripción:

Dihidrocloruro de manidipino es un bloqueador de canales de calcio utilizado principalmente en el tratamiento de la hipertensión y ciertas condiciones cardiovasculares. Pertenece a la clase de antagonistas del calcio dihidropiridínicos, que actúan inhibiendo la entrada de iones de calcio a través de los canales de calcio tipo L en el músculo liso vascular y el tejido cardíaco, lo que lleva a la vasodilatación y a una reducción de la presión arterial. La sustancia se caracteriza por su forma de sal dihidrocloruro, que mejora su solubilidad y biodisponibilidad. Manidipina presenta una larga vida media, lo que permite una dosificación una vez al día, mejorando la adherencia del paciente. Su perfil farmacológico incluye no solo efectos antihipertensivos, sino también beneficios potenciales en la reducción de la demanda de oxígeno miocárdico. El compuesto se administra típicamente por vía oral y puede estar asociado con efectos secundarios como edema periférico, dolor de cabeza y rubor. Al igual que con cualquier medicamento, es esencial considerar las contraindicaciones y las interacciones con otros fármacos. En general, Dihidrocloruro de manidipino es un agente terapéutico valioso en el manejo de la hipertensión y problemas cardiovasculares relacionados.

Fórmula: C₃₅H₄₀Cl₂N₄O₆

InChI: InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H

Clave InChI: InChIKey=JINNGBXKBDUGQT-UHFFFAOYSA-N

SMILES: C(OCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5.Cl

Sinónimos:

• 2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride
• 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester, Hydrochloride (1:2)
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
• Calslot
• Cv 4093
• Franidipine hydrochloride
• Manidipine hydrochloride
• (±)-Manidipine dihydrochloride
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
• CV-4093(2HCl)
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• franidipinehydrochloride
• cv-4093dihydrochlorde

Manidipine Dihydrochloride

CAS: 89226-50-6, 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 683.63

Ref: 3B-M2225

Manidipine dihydrochloride

CAS: 89226-75-5

Calcium channel blocker

Fórmula: C₃₅H₃₈N₄O₆•2HCl

Peso molecular: 683.63

Ref: 02-J60496

Manidipine DiHCl

CAS: 89226-75-5

Fórmula: C₃₅H₃₈Cl₂N₄O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 683.6213

Ref: IN-DA0043GI

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride (Manidipine 2HCl) is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).

Fórmula: C₃₅H₄₀Cl₂N₄O₆

Pureza: 99.76% - 99.86%

Forma y color: Solid

Peso molecular: 683.62

Ref: TM-T0193

Manidipine Dihydrochloride

CAS: 89226-75-5

Manidipine Dihydrochloride

Pureza: 99%

Peso molecular: 683.62g/mol

Ref: 54-OR1013718

Manidipine DiHCl

CAS: 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Forma y color: Off-White Solid

Peso molecular: 610.71 2*36.46

Ref: 4Z-M-2610

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride

Pureza: ≥98%

Peso molecular: 683.62g/mol

Ref: 54-BUP14828

Manidipine dihydrochloride

CAS: 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Pureza: ≥ 98.0%

Forma y color: White to pale yellow powder or crystals

Peso molecular: 683.63

Ref: 7W-GP1065

Manidipine Dihydrochloride

Producto controlado

CAS: 89226-75-5

Applications Manidipine Dihydrochloride is a metabolite of Manidipine (M164000), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992); Hosaka, S., et al.: Chem. Pharma. Bulletin., 55, 793 (2007);

Fórmula: C₃₅H₃₈N₄O₆·2ClH

Forma y color: Neat

Peso molecular: 683.6213

Ref: TR-M164015

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine is an antagonist of L-and T-type calcium channels that are present on smooth muscle cells. Manidipine is clinically used in hypertensive patients to achieve a significant peripheral vasodilation without an associated cardiodepression. In 2020, manidipine was identified as a potential drug in the treatment of COVID-19.

Fórmula: C₃₅H₃₈N₄O₆•(HCl)₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 683.62 g/mol

Ref: 3D-FM65072