CAS 90614-49-6

L-Valil-L-prolil-L-leucina

Descripción:

L-Valil-L-prolil-L-leucina, con el número CAS 90614-49-6, es un tripeptido compuesto por tres aminoácidos: valina, prolina y leucina. Este compuesto se caracteriza por su secuencia específica, que influye en sus propiedades estructurales y funcionales. Como un péptido, exhibe características típicas de los aminoácidos, incluida la capacidad de formar enlaces de hidrógeno y participar en diversas interacciones bioquímicas. La presencia de prolina, conocida por su estructura cíclica única, puede impartir rigidez a la cadena peptídica, afectando su conformación y estabilidad. L-Valil-L-prolil-L-leucina puede desempeñar un papel en procesos biológicos, influyendo potencialmente en el plegamiento de proteínas, la actividad enzimática o las vías de señalización celular. Además, péptidos como este a menudo se estudian por sus posibles aplicaciones terapéuticas, incluidos sus roles en el diseño y desarrollo de fármacos. Su solubilidad, estabilidad y reactividad pueden variar según las condiciones ambientales, como el pH y la temperatura, lo que lo convierte en un tema de interés tanto en la investigación bioquímica como en las formulaciones farmacéuticas.

Fórmula: C₁₆H₂₉N₃O₄

InChI: InChI=1/C16H29N3O4/c1-9(2)8-11(16(22)23)18-14(20)12-6-5-7-19(12)15(21)13(17)10(3)4/h9-13H,5-8,17H2,1-4H3,(H,18,20)(H,22,23)

Clave InChI: InChIKey=NHXZRXLFOBFMDM-AVGNSLFASA-N

SMILES: C([C@H](C(C)C)N)(=O)N1[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC1

Sinónimos:

• 468: PN: WO2005081628 SEQID: 470 claimed protein
• <span class="text-smallcaps">L</smallcap>-Leucine, <smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-(1-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl)-
• <span class="text-smallcaps">L</smallcap>-Valyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-leucine
• H-Val-Pro-Leu-OH
• L-valyl-L-prolyl-L-leucine
• Valylprolylleucine
• Diprotin B
• L-Leucine, L-valyl-L-prolyl-
• L-Leucine, N-(1-L-valyl-L-prolyl)-
• (-)-L-Val-L-Pro-L-Leu-OH
• L-VALYL-L-PROLYL LEUCINE
• VAL-PRO-LEU
• n-(1-l-valyl-l-prolyl)-l-leucin
• Val-Pro-Leu-OH
• 2-[[1-(2-amino-3-methylbutanoyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid

L-Leucine, L-valyl-L-prolyl-

CAS: 90614-49-6

Fórmula: C₁₆H₂₉N₃O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 327.4192

Ref: IN-DA00IG8H

Diprotin B

CAS: 90614-49-6

Diprotin B

Pureza: 98%

Peso molecular: 327.42g/mol

Ref: 54-OR1035879

Diprotin B

CAS: 90614-49-6

Fórmula: C₁₆H₂₉N₃O₄

Peso molecular: 327.40

Ref: 7W-GA4837

Diprotin B

CAS: 90614-49-6

Diprotin B is a colony-stimulating factor protein that has inhibitory properties in the colon. It has been shown to be effective in reducing symptoms of bowel disease and inflammatory bowel disease, as well as reducing the recurrence of colon cancer. Diprotin B inhibits the release of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The inhibition of these proinflammatory cytokines may contribute to the anti-inflammatory effects observed with Diprotin B treatment. Diprotin B also prevents cytosolic calcium accumulation, which can lead to cell lysis. This process is mediated by antimicrobial peptides called defensins that are expressed in Paneth cells found in the small intestine and colon. Defensins have also been shown to induce cell lysis through their ability to bind to bacterial membranes.

Fórmula: C₁₆H₂₉N₃O₄

Pureza: Min. 95%

Peso molecular: 327.43 g/mol

Ref: 3D-IDB-3982-PI

Diprotin B

CAS: 90614-49-6

Diprotin B is a dipeptidyl peptidase IV inhibitor.

Fórmula: C₁₆H₂₉N₃O₄

Pureza: 98%

Forma y color: White Lyophilized Powder

Peso molecular: 327.42

Ref: TM-T25341

Diprotin B

CAS: 90614-49-6

Diprotin B is a peptide that is the most potent inhibitor of serine proteases identified to date. It has been shown to inhibit both chymotrypsin and trypsin, with an IC50 value of 0.5 nM for chymotrypsin and 2 nM for trypsin. Diprotin B is able to inhibit the enzymatic activity by protonation at the catalytic residue, S2, in the active site of serine proteases. The efficiency of this inhibition can be increased by altering pH or adding proton donors such as HCl or NaOH. This peptide also hydrolyzes at a slower rate than the substrate (chymotrypsin). Diprotin B has a molecular weight of 906 Da and contains two amino acids: valine (Val) and leucine (Leu). It contains no functional groups that would be expected to affect its inhibitory properties.

Fórmula: C₁₆H₂₉N₃O₄

Pureza: Min. 95%

Peso molecular: 327.42 g/mol

Ref: 3D-FD109478