CAS 9076-44-2

Quimostatina

Descripción:

Quimostatina es un inhibidor potente y selectivo de las serina proteasas, dirigido particularmente a la quimotripsina y enzimas relacionadas. Es un producto natural derivado de la fermentación de ciertos actinobacterias, específicamente especies de Streptomyces. Quimostatina exhibe una estructura única que le permite unirse de manera efectiva al sitio activo de las serina proteasas, evitando así el acceso del sustrato e inhibiendo la actividad enzimática. Esta característica lo convierte en una herramienta valiosa en la investigación bioquímica para estudiar las funciones y mecanismos de las proteasas. Además, se ha investigado Quimostatina por sus posibles aplicaciones terapéuticas, particularmente en la investigación del cáncer, debido a su capacidad para modular los procesos proteolíticos involucrados en la progresión tumoral y la metástasis. El compuesto se utiliza típicamente en entornos de laboratorio, y su efectividad puede variar según la proteasa específica que se esté estudiando. Al igual que con muchos inhibidores de proteasas, es esencial considerar cuidadosamente la concentración y las condiciones experimentales para obtener resultados óptimos en aplicaciones de investigación.

Fórmula: Unspecified

InChI: InChI=1/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC[C@H](C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC(C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O

Sinónimos:

• Chymostatin
• N-{[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}pentan-2-yl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S,2S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid

Chymostatin

CAS: 9076-44-2

For research use

Forma y color: White to off-white, Powder

Ref: 02-J63275

Chymostatin (microbial product)

CAS: 9076-44-2

The microbial product is a mixture of the chymostatins A, B, and C. It inhibits most cysteine proteases, especially chymotrypsin. Chymostatin is often applied for inhibiting chymase.

Forma y color: White Powder

Ref: 01-4030514

Chymostatin

CAS: 9076-44-2

Fórmula: C₃₁H₄₁N₇O₆

Peso molecular: 604.90

Ref: 7W-GP4687

Chymostatin

CAS: 9076-44-2

Chymostatin is a protein that inhibits the polymerase chain reaction (PCR) by binding to the DNA polymerase. It has been shown to have a hypoglycemic effect in mice with myocardial infarcts and can also induce apoptosis in inflammatory lesions. Chymostatin binds to intracellular targets, such as cell factor and pro-apoptotic protein, which are involved in energy metabolism and inflammatory lesion. The inhibition of these targets may be due to its chemical biology properties, which include the formation of disulfide bonds and basic proteins. Chymostatin is not active against bacterial cells but can inhibit enzyme activities in mammalian cells.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.71 g/mol

Ref: 3D-ICY-4063

Chymostatin

CAS: 9076-44-2

Inhibitor of chymotrypsin

Fórmula: C₃₁H₄₁N₇O₆

Forma y color: White To Yellowish Solid

Peso molecular: 607.7 g/mol

Ref: 3D-FC29634

Chymostatin (0.5 mg vial)

CAS: 9076-44-2

Chymostatin is a protein-based inhibitor that binds to the receptor site of amyloid beta peptides, preventing them from aggregating and thereby inhibiting the formation of amyloid plaques. It has been shown that chymostatin inhibits ion channels, ligand-gated channels, and voltage-gated channels. Chymostatin is a high purity product with an average purity of 99% by HPLC analysis. It is also available in a variety of concentrations (0.5 mg vial).

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.72 g/mol

Ref: 3D-ICY-4063-V

Chymostatin

CAS: 9076-44-2

Fórmula: C₃₁H₄₁N₇O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 607.7005400000002

Ref: IN-DA00ILR4