CAS 90954-53-3

péptido relacionado con el gen de la calcitonina humano

Descripción:

El péptido relacionado con el gen de la calcitonina (CGRP) es un neuropeptido que desempeña un papel significativo en varios procesos fisiológicos, particularmente en el sistema nervioso y la regulación cardiovascular. Se deriva del gen de la calcitonina y está involucrado principalmente en la vasodilatación y la transmisión de señales de dolor. El CGRP está compuesto por una secuencia de aminoácidos, lo que lo convierte en un péptido, y existe en dos isoformas: alfa y beta, siendo la forma alfa predominante en los humanos. Se conoce que el péptido tiene potentes efectos vasodilatadores, que contribuyen a su papel en la fisiopatología de la migraña. El CGRP también está implicado en respuestas inflamatorias y se ha estudiado por sus posibles aplicaciones terapéuticas en condiciones como migrañas y otros trastornos del dolor. Su actividad biológica se media a través de receptores específicos, conocidos como receptores de CGRP, que son receptores acoplados a proteínas G. El número CAS 90954-53-3 identifica de manera única esta sustancia en bases de datos químicas, facilitando la investigación y el desarrollo en farmacología y bioquímica.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChI: InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Sinónimos:

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS: 90954-53-3

For cellular and molecular biology applications

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Peso molecular: 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS: 90954-53-3

Bachem ID: 4013281.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: 97.62%

Forma y color: White

Peso molecular: 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS: 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS: 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: Min. 95%

Peso molecular: 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS: 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: Min. 95%

Peso molecular: 3,789.3 g/mol

Ref: 3D-PCG-4160-V