CAS 911-77-3

Clorhidrato de N-α-benzoyl-DL-arginina-p-nitroanilida

Descripción:

Clorhidrato de N-α-benzoyl-DL-arginina-p-nitroanilida, comúnmente conocido como BAPNA, es un compuesto sintético utilizado principalmente como sustrato en ensayos bioquímicos para estudiar enzimas proteolíticas, particularmente proteasas de serina. Este compuesto presenta un grupo bencilo unido al aminoácido arginina, con un moiety de p-nitroanilida que sirve como indicador cromogénico. Tras la escisión enzimática por parte de las proteasas, BAPNA libera p-nitroanilina, que puede medirse cuantitativamente debido a su cambio de color distintivo, lo que lo convierte en una herramienta valiosa en estudios de cinética enzimática. BAPNA es típicamente un polvo cristalino blanco a blanco sucio, soluble en disolventes orgánicos y ligeramente soluble en agua. Su estructura molecular contribuye a su estabilidad y reactividad, permitiendo un monitoreo efectivo de la actividad enzimática. Además, como sal de clorhidrato, exhibe una solubilidad mejorada en soluciones acuosas, facilitando su uso en diversas aplicaciones de laboratorio. Las condiciones adecuadas de manejo y almacenamiento son esenciales para mantener su integridad y efectividad en entornos experimentales.

Fórmula: C₁₉H₂₂N₆O₄·ClH

InChI: InChI=1S/C19H22N6O4.ClH/c20-19(21)22-12-4-7-16(24-17(26)13-5-2-1-3-6-13)18(27)23-14-8-10-15(11-9-14)25(28)29;/h1-3,5-6,8-11,16H,4,7,12H2,(H,23,27)(H,24,26)(H4,20,21,22);1H

Clave InChI: InChIKey=DEOKFPFLXFNAON-UHFFFAOYSA-N

SMILES: N(C(C(NC(=O)C1=CC=CC=C1)CCCNC(=N)N)=O)C2=CC=C(N(=O)=O)C=C2.Cl

Sinónimos:

• Benzamide, N-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, hydrochloride (1:1)
• Benzamide, N-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, monohydrochloride
• N-Benzoyl-Dl-Arginine-4-Nitroanilide Hydrochloride
• N-α-Benzoyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-arginine-p-nitroanilide hydrochloride
• N^α-Benzoyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-arginine-p-nitroanilide hydrochloride
• NSC 83264
• Valeranilide, 2-benzamido-5-guanidino-4′-nitro-, monohydrochloride, <span class="text-smallcaps">DL</span>-
• Nα-Benzoyl-DL-arginine-p-nitroanilide hydrochloride
• Valeranilide, 2-benzamido-5-guanidino-4′-nitro-, monohydrochloride, DL-

Bz-DL-Arg-pNA · HCl

CAS: 911-77-3

Substrate for trypsin, papain, acrosin, plasmin, cathepsin B, and cathepsin H.

Fórmula: C₁₉H₂₂N₆O₄·HCl

Pureza: ≥ 99%

Forma y color: Light Yellow

Peso molecular: 434.88

Ref: 01-4001028

Benzamide, N-​[4-​[(aminoiminomethyl)​amino]​-​1-​[[(4-​nitrophenyl)​amino]​carbonyl]​butyl]​-​, hydrochloride (1:1)

CAS: 911-77-3

Fórmula: C₁₉H₂₃ClN₆O₄

Pureza: 97%

Forma y color: Solid

Peso molecular: 434.8767

Ref: IN-DA00IGHF

N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride

CAS: 911-77-3

N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride

Fórmula: C₁₉H₂₂N₆O₄·ClH

Forma y color: Pale Yellow Powder

Peso molecular: 434.88g/mol

Ref: 54-BIB1056

N-Benzoyl-DL-arginine 4-nitroanilide hydrochloride

CAS: 911-77-3

N-α-benzoyl-DL-arginine-4-nitroanilide hydrochloride is commonly used as a substrate in various enzymatic assays, particularly for studying proteases like trypsin and chymotrypsin. It serves as a synthetic substrate to measure the activity of these enzymes. For instance, it has been used to determine trypsin activity in different organisms and tissues. The substrate has also been employed in studying the enzymatic properties of various proteases, including those found in latex, snake venoms,  and plant seeds. Additionally, it has been utilized to assess the effects of different compounds on trypsin activity, such as condensed tannins and wine.

Fórmula: C₁₉H₂₂N₆O₄•HCl

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 434.88 g/mol

Ref: 3D-EB32011

N-a-Benzoyl-DL-Arginine-4-Nitroanilide Hydrochloride (BANI, L-BAPNA) extrapure, 98%

CAS: 911-77-3

Fórmula: C₁₉H₂₂N₆O₄·HCl

Pureza: min. 98%

Forma y color: Yellow, Powder

Peso molecular: 434.89

Ref: SR-96249

N-(5-Guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)benzamide hydrochloride

CAS: 911-77-3

Fórmula: C₁₉H₂₃ClN₆O₄

Pureza: 97%

Peso molecular: 434.88

Ref: 10-F544662

Bz-DL-Arg-pNA • HCl [DL-BAPA]

CAS: 911-77-3

Bz-DL-Arg-pNA • HCl [DL-BAPA] is a trypsin and trypsin-like protease substrate. It is used as a tool in biochemical studies to investigate the degradation of proteins by these enzymes. Bz-DL-Arg-pNA • HCl [DL-BAPA] is also used as an experimental model for diseases that affect enzyme activity, such as rheumatoid arthritis and multiple sclerosis.

Fórmula: C₁₉H₂₂N₆O₄•HCl

Pureza: Min. 95%

Peso molecular: 434.88 g/mol

Ref: 3D-SRN-3013