CAS 91224-37-2

(D-arg1,D-trp7,9,leu11)-sustancia P*acetato

Descripción:

(D-arg1,D-trp7,9,leu11)-sustancia P*acetato, con el número CAS 91224-37-2, es un análogo sintético de la sustancia P, un neuropeptido involucrado en varios procesos fisiológicos, incluida la percepción del dolor y la inflamación. Este compuesto se caracteriza por su secuencia de aminoácidos modificada, que incluye D-arginina en la posición 1, D-triptófano en las posiciones 7 y 9, y leucina en la posición 11, mejorando su estabilidad y afinidad de unión a los receptores en comparación con el péptido natural. El componente de acetato indica que el compuesto está en su forma de sal de acetato, lo que puede influir en su solubilidad y biodisponibilidad. Típicamente, tales análogos se estudian por sus posibles aplicaciones terapéuticas, particularmente en el manejo del dolor y la neurobiología, debido a su capacidad para interactuar con los receptores de neuroquinina. Las modificaciones estructurales tienen como objetivo mejorar las propiedades farmacológicas mientras se reduce la susceptibilidad a la degradación enzimática. En general, este compuesto representa un interés significativo en la química medicinal y la farmacología para el desarrollo de nuevos tratamientos dirigidos a las vías de neuropeptidos.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

InChI: InChI=1/C75H108N20O13/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83)/t49-,52?,53+,54+,55+,56?,57+,58-,59-,60?,61?/m1/s1

Sinónimos:

• (D-Arg1,D-Trp79,Leu11)-Substance P
• H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
• D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride

(D-Arg¹,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 91224-37-2

Spantide I, a high potency substance P antagonist with a weak spasmogenic and a poor histamine releasing effect.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: 95.2%

Forma y color: Beige Powder

Peso molecular: 1497.81

Ref: 01-4004691

[D-Arg1, D-Trp7,9, Leu11]-Substance P

CAS: 91224-37-2

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Peso molecular: 1497.79

Ref: 7W-GL0691

Spantide I

CAS: 91224-37-2

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 1497.79

Ref: TM-T20413

[D-Arg1,D-Trp7,9,Leu11]-Substance P

CAS: 91224-37-2

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: Min. 95%

Peso molecular: 1,497.8 g/mol

Ref: 3D-PSP-4173-V

(D-Arg1,D-Trp7·9,Leu11)-Substance P

CAS: 91224-37-2

Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: Min. 95%

Peso molecular: 1,497.79 g/mol

Ref: 3D-FA108555