CAS 92921-24-9

Sulfo-SMCC sodio

Descripción:

Sulfo-SMCC sodio, con el número CAS 92921-24-9, es un compuesto químico comúnmente utilizado como agente de entrecruzamiento en bioconjugación y química de proteínas. Es un reactivo soluble en agua que facilita la formación de enlaces covalentes estables entre proteínas, péptidos y otras biomoléculas, lo que lo hace valioso en diversas aplicaciones como el desarrollo de fármacos, diagnósticos y la creación de conjugados de anticuerpos y fármacos. El compuesto presenta un grupo sulfonato, que mejora su solubilidad en soluciones acuosas, y una parte de maleimida que reacciona selectivamente con grupos tiol en residuos de cisteína de proteínas. Esta especificidad permite modificaciones precisas de biomoléculas, lo que permite a los investigadores estudiar interacciones, estabilidad y función de las proteínas. Además, Sulfo-SMCC sodio se caracteriza por sus condiciones de reacción suaves, lo que lo hace adecuado para su uso con moléculas biológicas sensibles. Se deben observar precauciones de seguridad al manipular este reactivo, como con cualquier químico, para minimizar la exposición y garantizar prácticas de laboratorio adecuadas.

Fórmula: C₁₆H₁₇N₂NaO₉S

InChI: InChI=1/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1/rC16H17N2NaO9S/c19-28-29(25,26)11-7-14(22)18(15(11)23)27-16(24)10-3-1-9(2-4-10)8-17-12(20)5-6-13(17)21/h5-6,9-11H,1-4,7-8H2

Clave InChI: InChIKey=VRMVBDHSLMDJAD-UHFFFAOYSA-N

SMILES: O(C(=O)C1CCC(CN2C(=O)C=CC2=O)CC1)N3C(=O)C(S(=O)(=O)O)CC3=O.[Na]

Sinónimos:

• 3-Pyrrolidinesulfonic acid, 1-[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]oxy]-2,5-dioxo-, sodium salt
• Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt (1:1)
• SMCC, Water-Soluble
• Sulfo-SMCC sodium
• Sulfo-Smcc
• Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• [1-[4-[(2,5-Dioxopyrrol-1-Yl)Methyl]Cyclohexanecarbonyl]Oxy-2,5-Dioxo-Pyrrolidin-3-Yl]Sulfonyloxysodium
• SULFO-SMCC SulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)cyclohexane-1-carboxylate
• Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate
• 3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-Cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1)
• 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester
• SULFOSUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
• Sulpho SMCC sodium salt
• SULFO SUCCINIMIDYL-4-(N-MALEIMIDO METHYL) CYCLOHEXANE-1-CARBOXYLATE
• Sulfo-SMCCSulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)
• Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate
• 3-Sulfo-N-succiniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate SodiuM Salt
• 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID 3-SULFO-N-HYDROXYSUCCINIMIDE ESTER SODIUM SALT
• Sulfo-N-Succinimidyl-4-(malemidonethyl)cyclohexane-1-carboxylate,sodium salt
• Sulfo-SMCC SodiuM Salt
• 4-(MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)Methyl]cyclohexanecarboxylic Acid 2,5-Dioxo-3-sulfo-1-pyrrolidinyl Ester, SodiuM Salt
• SULFO-N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE, SODIUM SALT
• Sulfo-SMCC Crosslinker
• SulfosucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate(Sulfo-SMCC)

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt, 97+%

CAS: 92921-24-9

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt is a cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second co

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 97+%

Forma y color: Off-white to white, Solid

Peso molecular: 436.37

Ref: 02-H54807

Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate, Sodium Salt

CAS: 92921-24-9

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 96%

Forma y color: Solid

Peso molecular: 436.3689

Ref: IN-DA006K94

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

CAS: 92921-24-9

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

Pureza: 95%

Peso molecular: 436.37g/mol

Ref: 54-OR1030515

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium

Pureza: ≥98%

Peso molecular: 436.37g/mol

Ref: 54-BUP11004

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

CAS: 92921-24-9

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

Fórmula: C₁₆H₁₇N₂O₉S·Na

Pureza: 98% (Typical Value in Batch COA)

Forma y color: white solid

Peso molecular: 436.37g/mol

Ref: 54-BICL207

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium: hetero-bifunctional ADC crosslinker with NHS ester and maleimide for amines and sulfhydryls.

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 98.07% - 99.9%

Forma y color: Solid

Peso molecular: 436.37

Ref: TM-T18728

Sulfo-SMCC sodium

CAS: 92921-24-9

Crosslinker reacting rapidly with primary amines.  It is used as a protein crosslinker where it reacts with cysteine to yield specific conjugates.  The cyclohexane bridge confers added stability to the maleimide group making it ideal for maleimide activation of proteins.  It is soluble in water and many other aqueous buffers although it is less stable then in DMSO or DMF.

Fórmula: C₁₆H₁₇N₂O₉SNa

Pureza: Min. 95 Area-%

Forma y color: White Off-White Powder

Peso molecular: 436.37 g/mol

Ref: 3D-FS27953

Sulfo-SMCC sodium

CAS: 92921-24-9

Pureza: 96%

Peso molecular: 436.3699951

Ref: 10-F869416

3-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt

CAS: 92921-24-9

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: >97.0%(qNMR)

Forma y color: White to Almost white powder to crystal

Peso molecular: 436.37

Ref: 3B-S0883