CAS 936563-96-1

1-((3r)-3-(4-amino-3-(4-fenoxifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-ona

Descripción:

La sustancia química conocida como 1-((3r)-3-(4-amino-3-(4-fenoxifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-ona, con el número CAS 936563-96-1, es un compuesto orgánico complejo caracterizado por su estructura multifuncional. Presenta un núcleo de pirazolo-pirimidina, conocido por su actividad biológica, particularmente en química medicinal. La presencia de un grupo amino y un moiety de fenoxifenilo sugiere interacciones potenciales con objetivos biológicos, lo que lo convierte en un candidato para aplicaciones farmacéuticas. El anillo de piperidina contribuye a su basicidad y puede influir en sus propiedades farmacocinéticas. Además, el grupo carbonilo α,β-insaturado (2-propen-1-ona) es significativo para la reactividad, permitiendo potencialmente modificaciones químicas adicionales. En general, la estructura intrincada de este compuesto indica un potencial para diversas actividades biológicas, lo que justifica una mayor investigación en el desarrollo de fármacos y aplicaciones terapéuticas.

Fórmula: C₂₅H₂₄N₆O₂

InChI: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1

Clave InChI: InChIKey=XYFPWWZEPKGCCK-GOSISDBHSA-N

SMILES: NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1

Sinónimos:

• (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-propenone
• 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-
• Cra 032765
• Ibrutinib
• Imbruvica
• Jnj 02
• Pci 32765-00
• Pci-32765
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• PCI-32765 (Ibrutinib)
• Ibrutinib (PCI-32765)
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one

1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 440.4971

Ref: IN-DA003620

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Pureza: 98%

Peso molecular: 440.5g/mol

Ref: 54-OR1029554

Ibrutinib (PCI-32765)

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Forma y color: White To Off-White Solid

Peso molecular: 440.51

Ref: 4Z-I-061003

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Pureza: ≥98%

Peso molecular: 440.5g/mol

Ref: 54-BUP15079

Ibrutinib

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Pureza: ≥ 98.0%

Forma y color: White or almost white powder

Peso molecular: 440.50

Ref: 7W-GP8742

Ibrutinib

Producto controlado

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Forma y color: Neat

Peso molecular: 440.50

Ref: 86-MM3746.00

Ibrutinib

CAS: 936563-96-1

Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.

Fórmula: C₂₅H₂₄N₆O₂

Pureza: 98% - 99.93%

Forma y color: Solid

Peso molecular: 440.5

Ref: TM-T1835

Ibrutinib

Producto controlado

CAS: 936563-96-1

Applications Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Fórmula: C₂₅H₂₄N₆O₂

Forma y color: Off-White

Peso molecular: 440.50

Ref: TR-I124970

Ibrutinib-d4 (Major)

Producto controlado

CAS: 936563-96-1

Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Fórmula: C₂₅H₂₀D₄N₆O₂

Forma y color: Neat

Peso molecular: 444.52

Ref: TR-I124971

Ibrutinib

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Fórmula: C₂₅H₂₄O₂N₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 440.5 g/mol

Ref: 3D-FA34130

Ibrutinib - Bio-X ™

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Fórmula: C₂₅H₂₄O₂N₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 440.5 g/mol

Ref: 3D-BI164531

Ibrutinib

CAS: 936563-96-1

Pureza: 99%

Peso molecular: 440.51

Ref: 10-F799864