CAS 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Descripción:

Suc-Leu-Leu-Val-Tyr-AMC, también conocido como un sustrato peptídico, es un compuesto sintético que consiste en una secuencia de aminoácidos: leucina succinilada, leucina, valina, tirosina y 7-amido-4-metilcumarina (AMC). Este compuesto se utiliza principalmente en ensayos bioquímicos para estudiar enzimas proteolíticas, particularmente aquellas que rompen enlaces peptídicos. El grupo succinilo mejora la solubilidad y estabilidad del péptido, mientras que la parte AMC sirve como un reportero fluorescente, permitiendo la detección de la actividad enzimática a través de mediciones de fluorescencia. Las características de esta sustancia incluyen su capacidad para sufrir hidrólisis por proteasas específicas, lo que resulta en la liberación de AMC, que puede medirse cuantitativamente. Esta propiedad la hace valiosa en aplicaciones de investigación, particularmente en los campos de la enzimiología y el descubrimiento de fármacos. Además, la estructura de Suc-Leu-Leu-Val-Tyr-AMC contribuye a su especificidad para ciertas enzimas, lo que la convierte en una herramienta útil para estudiar la cinética enzimática y la inhibición.

Fórmula: C₄₀H₅₃N₅O₁₀

InChI: InChI=1/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29?,30?,31-,36-/m0/s1

SMILES: CC(C)CC(C(=NC(CC(C)C)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)O)N=C(CCC(=O)O)O

Sinónimos:

• N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma
• Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
• Llvy-mca
• N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin
• Sllvt-mca
• Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin
• Suc-leu-leu-val-tyr-mca
• Suc-llvy-mca
• L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: > 98%

Forma y color: White

Peso molecular: 763.89

Ref: 01-4011369

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: 95%

Forma y color: Solid

Peso molecular: 763.8763

Ref: IN-DA01E5Y8

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: 98%

Forma y color: Solid

Peso molecular: 763.88

Ref: TM-TP1308

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS: 94367-21-2

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: ≥ 95.0%

Forma y color: White to off-white powder

Peso molecular: 763.89

Ref: 7W-GL1880

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a peptide that is an activator of ion channels. It can be used to study the effects of ion channel activation on various cells and tissues. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to inhibit ligand binding to some receptors, such as the acetylcholine receptor. This peptide can also be used as a research tool for pharmacology, protein interactions, and antibody production.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: Min. 95%

Peso molecular: 763.88 g/mol

Ref: 3D-MLL-3120-V

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a cyclin D2 inhibitor that binds to the proteasome and inhibits its function. It has been shown to be useful for the treatment of cancerous tissues as it inhibits the production of prostaglandin J2, which is involved in the progression of cancer cells. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to have antioxidant properties and can inhibit oxidative injury. This drug may be used to prevent or treat various diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, diabetes mellitus type II, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and septic shock.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 763.88 g/mol

Ref: 3D-FS110535