CAS 964-21-6

O6-Metil-2'-desoxiguanosina

Descripción:

O6-Metil-2'-desoxiguanosina es un nucleósido modificado que surge de la metilación de la base de guanina en la posición O6. Esta modificación puede ocurrir como resultado de la exposición a ciertos agentes alquilantes, lo que puede llevar a daños en el ADN y potencialmente contribuir a la mutagénesis y carcinogénesis. La estructura de O6-Metil-2'-desoxiguanosina consiste en un azúcar desoxirribosa unido a una base de guanina metilada, lo que altera las propiedades de emparejamiento de bases durante la replicación del ADN. Este compuesto es de gran interés en biología molecular e investigación del cáncer, ya que sirve como un biomarcador para el daño del ADN y está involucrado en el estudio de los mecanismos de mutagénesis. Además, O6-Metil-2'-desoxiguanosina puede influir en la actividad de las enzimas de reparación del ADN, particularmente aquellas involucradas en la vía de reparación por escisión de bases. Su presencia en el ADN puede llevar a emparejamientos incorrectos durante la replicación, resultando en transiciones de G:C a A:T, que son mutaciones comunes observadas en varios cánceres. Comprender sus características es crucial para desarrollar estrategias que mitiguen los efectos del daño en el ADN en las células.

Fórmula: C₁₁H₁₅N₅O₄

InChI: InChI=1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+/m0/s1

Clave InChI: InChIKey=BCKDNMPYCIOBTA-RRKCRQDMSA-N

SMILES: O(C)C1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)=NC(N)=N1

Sinónimos:

• 2'-Deoxy-O(6)-methylguanosine
• 2-Amino-6-methoxy-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)purine
• 2′-Deoxy-6-O-methylguanosine
• 2′-Deoxy-6-methylguanosine
• 6-O-Methyl-2′-deoxyguanosine
• 6-O-Methyldeoxyguanosine
• 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methoxy-9H-purin-2-amine
• 9H-Purine, 2-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-6-methoxy-
• 9H-Purine, 2-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-6-methoxy-
• Guanosine, 2'-deoxy-6-O-methyl-
• O(6)-Methyl-2'-deoxyguanosine
• O(6)-Methyldeoxyguanosine
• O⁶-Methyl-2′-deoxyguanosine
• O⁶-Methyldeoxyguanosine
• 9H-Purine, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxy-
• 9H-Purine, 2-amino-9-(2-deoxy-β-D-ribofuranosyl)-6-methoxy-

O6-Methyl-deoxyguanosine

CAS: 964-21-6

Fórmula: C₁₁H₁₅N₅O₄

Pureza: 90%

Forma y color: Solid

Peso molecular: 281.2679

Ref: IN-DA00VRT6

6-O-Methyldeoxyguanosine

CAS: 964-21-6

6-O-Methyldeoxyguanosine

Pureza: 95%

Peso molecular: 281.27g/mol

Ref: 54-OR1005533

(2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

CAS: 964-21-6

Pureza: 98%

Peso molecular: 281.2720031738281

Ref: 10-F778196

O6-Methyl-2’-deoxyguanosine(>85%)

Producto controlado

CAS: 964-21-6

Applications O6-Methyl-2’-deoxyguanosine is a ubiquitous DNA lesion formed by xenobiotic carcinogens and endogenous methylating agent, S-adenosyl-L-methionine. A mutagenic adducts formed by a potent tobacco carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
References Patra, A., et al.: J. Biol. Chem., 291, 24304-24313 (2016); Gowda, A. S., et al.: Chem. Res. Toxicol., 29, 1894-1900 (2016)

Fórmula: C₁₁H₁₅N₅O₄

Pureza: >85%

Forma y color: Neat

Peso molecular: 281.27

Ref: TR-M293040

O6-Methyldeoxy guanosine

CAS: 964-21-6

O6-Methyldeoxy guanosine, a deoxypurine nucleoside, is a weak inhibitor of the removal of O6-methylguanine from methylated DNA by rat liver enzymes in vitro.

Fórmula: C₁₁H₁₅N₅O₄

Pureza: 99.57%

Forma y color: Solid

Peso molecular: 281.27

Ref: TM-TNU1537

2'-Deoxy-6-O-methyl-guanosine

CAS: 964-21-6

2'-Deoxy-6-O-methyl-guanosine is a methylated nucleoside that has been shown to inhibit protein synthesis in cancer cells. It does so by inhibiting the synthesis of DNA, which is required for the production of proteins. This compound also inhibits monoclonal antibody production, which may be due to its ability to methylate DNA and prevent dna duplexes from being repaired. 2'-Deoxy-6-O-methyl-guanosine is used as a probe in the detection of human proteins by fluorescence spectroscopy. The sensitivity of this probe has been shown to be greater than 10 ng/mL, making it ideal for use in clinical settings where small quantities of proteins are present.

Fórmula: C₁₁H₁₅N₅O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 281.27 g/mol

Ref: 3D-ND157121