CAS 992-21-2

Limeciclina

Descripción:

Limeciclina es un antibiótico semisintético que pertenece a la clase de las tetraciclinas, utilizado principalmente para tratar diversas infecciones bacterianas. Exhibe una actividad antibacteriana de amplio espectro contra bacterias Gram-positivas y Gram-negativas al inhibir la síntesis de proteínas mediante la unión a la subunidad ribosómica 30S. Esta acción previene el crecimiento y la reproducción de las bacterias. Limeciclina se caracteriza por su estabilidad en ambientes ácidos, lo que mejora su biodisponibilidad cuando se administra por vía oral. A menudo se prescribe para condiciones como el acné, infecciones del tracto respiratorio y ciertas infecciones cutáneas. El compuesto generalmente es bien tolerado, aunque puede causar efectos secundarios como trastornos gastrointestinales, fotosensibilidad y efectos potenciales en el desarrollo de huesos y dientes en niños. Al igual que otras tetraciclinas, está contraindicado en mujeres embarazadas y niños pequeños debido al riesgo de decoloración dental y efectos esqueléticos.

Fórmula: C₂₉H₃₈N₄O₁₀

InChI: InChI=1/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-16(27(40)41)8-4-5-10-30/h6-7,9,14-16,21,31-32,34-35,39,42-43H,4-5,8,10-12,30H2,1-3H3,(H,40,41)/b26-20+/t14?,15-,16?,21-,28+,29-/m0/s1

Clave InChI: InChIKey=AHEVKYYGXVEWNO-UEPZRUIBSA-N

SMILES: O[C@@]12[C@@](C[C@]3(C(=C1O)C(=O)C=4C([C@@]3(C)O)=CC=CC4O)[H])([C@H](N(C)C)C(O)=C(C(NCNCCCC[C@@H](C(O)=O)N)=O)C2=O)[H]

Sinónimos:

• (+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, lysinemethylene deriv.
• <span class="text-smallcaps">L</span>-Lysine, N⁶-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
• <span class="text-smallcaps">L</span>-Lysine, N⁶-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
• Armyl
• Ciclisin
• Ciclolysal
• Ciclolysine
• Infaciclina
• L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
• Limeciclina
• Lisinbiotic
• Lisinciclina
• Lymecyclin
• Lymecycline
• Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
• Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
• Lysine, N⁶-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
• Lysine, N⁶-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, <span class="text-smallcaps">L</span>-
• Mucomycin
• N-Lysinomethyltetracycline
• N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
• N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
• N6-[[[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-oxtahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
• N²-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
• N⁶-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
• N⁶-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-<span class="text-smallcaps">L</span>-lysine
• Tertamyl
• Tetracycline-<span class="text-smallcaps">L</span>-methylenelysine
• Tetracycline-L-methylenelysine
• Tetracyclinemethylenelysine
• Tetralisal
• Tetralysal
• Tetramyl
• Vebicyclysal
• L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
• N~2~-({[(Z)-[(4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
• (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• N~2~-({[(E)-[(4S,4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
• N-(N2-lysinomethyl)tetracycline
• N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
• lymecycline USP/EP/BP
• Lymecycline (85%)
• N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine
• Tetracyclinemethylene lysine

Lymecycline

CAS: 992-21-2

Lymecycline

Fórmula: C₂₂H₂₃ClN₂O₈

Forma y color: Dark Yellow

Peso molecular: 478.8796

Ref: 47-218

Lymecycline

CAS: 992-21-2

Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.

Fórmula: C₂₉H₃₈N₄O₁₀

Forma y color: Solid

Peso molecular: 602.64

Ref: TM-T20164

Lymecycline

CAS: 992-21-2

Fórmula: C₂₉H₃₈N₄O₁₀

Peso molecular: 602.64

Ref: 4Z-L-237001

Lymecycline-d8 (>80%)

Producto controlado

CAS: 992-21-2

Stability Light Sensitive, Temperature Sensitive
Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Fórmula: C₂₉H₃₀D₈N₄O₁₀

Pureza: >80%

Forma y color: Neat

Peso molecular: 610.68

Ref: TR-L487802

Lymecycline (85%)

CAS: 992-21-2

Stability Temperature sensitive
Applications A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Fórmula: C₂₉H₃₈N₄O₁₀

Pureza: 85%

Forma y color: Yellow To Dark Brown

Peso molecular: 602.63

Ref: TR-L487800

Lymecycline

CAS: 992-21-2

Lymecycline is a tetracycline antibiotic that has been shown to be effective in the treatment of inflammatory bowel disease, chronic arthritis, and experimental models of inflammatory reactions. Lymecycline inhibits epidermal growth factor (EGF) and its receptor EGF-R. This inhibition leads to reduced inflammation in the bowel. Lymecycline also has an anti-inflammatory effect on the skin, inhibiting reactive oxygen species (ROS) production from neutrophils and macrophages. It also reduces the symptoms of toxic epidermal necrolysis by preventing ROS production and reducing cytokines such as TNF-α and IL-1β. Lymecycline binds to magnesium ions, which are necessary for bacterial growth and replication. This binding leads to bacteriostatic activity against bacteria that are sensitive to lymecycline, including Mycobacterium tuberculosis and other infectious diseases. The histological

Fórmula: C₂₉H₃₈N₄O₁₀

Pureza: Min. 85 Area-%

Forma y color: Powder

Peso molecular: 602.63 g/mol

Ref: 3D-FL164019

Lymecycline

CAS: 992-21-2

Fórmula: C₂₉H₃₈N₄O₁₀

Peso molecular: 602.64

Ref: 4Z-T-405

Lymecycline-d8

CAS: 992-21-2

Fórmula: C₂₉H₃₀D₈N₄O₁₀

Peso molecular: 610.69

Ref: 4Z-T-406