TNF

Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to …

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it …

Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor …

Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective …

Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and …

Cepharanthine, a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation …

Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.

Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic …

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in …

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 …

Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated …

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.

Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark …

Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR …

Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.

De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects …

PP58 is an inhibitor of PDGFR, FGFR and Src family.

Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammatory …

Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may …

Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release …

CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 …

Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can …

Eburicoic acid exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage …

11-Hydroxytephrosin inhibits NF-kappaB activity.

Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, …

5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.

Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.

Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation …

Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis …

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced …

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen …

Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory …

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus …

Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a …

Hydrangenol 8-O-glucoside may have anti-inflammary activity.

EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can …

Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may …

Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, …

Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in …

Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a …

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to …

Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) …

(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. …

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also …

Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma …

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both …

Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly …

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. …

Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and …

Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide …

Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by …

2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB …

Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, …

Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against …

Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of …

Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be …

Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.

Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and …

Liguiritigenin-7-O-D-Apiosyl-4'-O-D-Glucoside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and …

Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and …

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen …

Methylnissolin is a natural product from A. membranaceus.

Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via …

Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic …

Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO …

Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity …

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively …

Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against …

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration …