Mdm2
Los inhibidores de Mdm2 se dirigen a la proteína Mdm2, una ligasa de ubiquitina E3 que regula negativamente al supresor tumoral p53. Mdm2 promueve la degradación de p53, evitando así la apoptosis en células que deberían morir. Inhibir Mdm2 estabiliza p53, mejorando su actividad supresora de tumores y promoviendo la apoptosis en células cancerosas. Los inhibidores de Mdm2 son cruciales en la investigación y terapia del cáncer, especialmente para cánceres con vías de p53 intactas. En CymitQuimica, ofrecemos inhibidores de Mdm2 de alta calidad para apoyar su investigación en biología del cáncer, apoptosis y desarrollo terapéutico.
Se han encontrado 12 productos de "Mdm2"
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Amifostine thiol
CAS:Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.Fórmula:C5H14N2SPureza:≥95.0%Forma y color:SolidPeso molecular:134.24CP-31398 dihydrochloride
CAS:CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.Fórmula:C22H28Cl2N4OPureza:98.23%Forma y color:SolidPeso molecular:435.4PK11007
CAS:PK11007 is an anti-p53 drug.Fórmula:C15H11ClFN5O3S2Pureza:97.55%Forma y color:SolidPeso molecular:427.86PhiKan 083
CAS:PhiKan 083 is a carbazole derivativeFórmula:C16H18N2Pureza:98.37%Forma y color:SolidPeso molecular:238.33Ref: TM-T16523L
1mg35,00€5mg70,00€10mg111,00€25mg235,00€50mg329,00€100mg464,00€500mg1.008,00€1mL*10mM (DMSO)75,00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:98.89% - >99.99%Forma y color:SolidPeso molecular:454.63Ref: TM-T1818
1mg43,00€2mg56,00€5mg77,00€10mg87,00€25mg157,00€50mg230,00€100mg393,00€500mg930,00€1mL*10mM (DMSO)79,00€NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Fórmula:C23H20N2OPureza:96.94%Forma y color:SolidPeso molecular:340.42Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Forma y color:SolidPeso molecular:369.48Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Forma y color:SolidPeso molecular:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Fórmula:C11H13N5O4Pureza:99.51%Forma y color:SolidPeso molecular:279.25Ref: TM-T6610
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)114,00€SP-141
CAS:SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.Fórmula:C22H16N2OPureza:98.01%Forma y color:SolidPeso molecular:324.38RDR03871
CAS:<p>RDR03871 is an MDM2 inhibitor.</p>Fórmula:C18H16ClF3N6Pureza:97.78%Forma y color:SolidPeso molecular:408.81MB710
CAS:MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Fórmula:C16H16IN3O3SPureza:99.02%Forma y color:SolidPeso molecular:457.29
