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Mdm2

Mdm2

Los inhibidores de Mdm2 se dirigen a la proteína Mdm2, una ligasa de ubiquitina E3 que regula negativamente al supresor tumoral p53. Mdm2 promueve la degradación de p53, evitando así la apoptosis en células que deberían morir. Inhibir Mdm2 estabiliza p53, mejorando su actividad supresora de tumores y promoviendo la apoptosis en células cancerosas. Los inhibidores de Mdm2 son cruciales en la investigación y terapia del cáncer, especialmente para cánceres con vías de p53 intactas. En CymitQuimica, ofrecemos inhibidores de Mdm2 de alta calidad para apoyar su investigación en biología del cáncer, apoptosis y desarrollo terapéutico.

Se han encontrado 12 productos de "Mdm2"

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  • Amifostine thiol
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    Amifostine thiol

    CAS:
    <p>Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.</p>
    Fórmula:C5H14N2S
    Pureza:≥95.0%
    Forma y color:Solid
    Peso molecular:134.24

    Ref: TM-T37538

  • CP-31398 dihydrochloride
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    CP-31398 dihydrochloride

    CAS:
    <p>CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.</p>
    Fórmula:C22H28Cl2N4O
    Pureza:98.23%
    Forma y color:Solid
    Peso molecular:435.4

    Ref: TM-T21648

  • PK11007
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    PK11007

    CAS:
    <p>PK11007 is an anti-p53 drug.</p>
    Fórmula:C15H11ClFN5O3S2
    Pureza:97.55%
    Forma y color:Solid
    Peso molecular:427.86

    Ref: TM-T7703

  • PhiKan 083
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    PhiKan 083

    CAS:
    <p>PhiKan 083 is a carbazole derivative</p>
    Fórmula:C16H18N2
    Pureza:98.37%
    Forma y color:Solid
    Peso molecular:238.33

    Ref: TM-T16523L

  • Tenovin-6
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    Tenovin-6

    CAS:
    <p>Tenovin-6 is a p53 transcriptional activity agonist.</p>
    Fórmula:C25H34N4O2S
    Pureza:97.71% - >99.99%
    Forma y color:Solid
    Peso molecular:454.63

    Ref: TM-T1818

  • NSC 66811
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    NSC 66811

    CAS:
    <p>NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.</p>
    Fórmula:C23H20N2O
    Pureza:96.94%
    Forma y color:Solid
    Peso molecular:340.42

    Ref: TM-T21578

  • Tenovin-1
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    Tenovin-1

    CAS:
    <p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>
    Fórmula:C20H23N3O2S
    Pureza:99.33%
    Forma y color:Solid
    Peso molecular:369.48

    Ref: TM-T1919

  • Tenovin-6 Hydrochloride
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    Tenovin-6 Hydrochloride

    CAS:
    <p>Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.</p>
    Fórmula:C25H35ClN4O2S
    Pureza:99.36%
    Forma y color:Solid
    Peso molecular:491.09

    Ref: TM-T8480

  • XI-006
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    XI-006

    CAS:
    <p>NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.</p>
    Fórmula:C11H13N5O4
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:279.25

    Ref: TM-T6610

  • SP-141
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    SP-141

    CAS:
    <p>SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.</p>
    Fórmula:C22H16N2O
    Pureza:98.01%
    Forma y color:Solid
    Peso molecular:324.38

    Ref: TM-T21773

  • RDR03871
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    RDR03871

    CAS:
    <p>RDR03871 is an MDM2 inhibitor.</p>
    Fórmula:C18H16ClF3N6
    Pureza:97.78%
    Forma y color:Solid
    Peso molecular:408.81

    Ref: TM-T28509

  • MB710
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    MB710

    CAS:
    <p>MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.</p>
    Fórmula:C16H16IN3O3S
    Pureza:99.02%
    Forma y color:Solid
    Peso molecular:457.29

    Ref: TM-T9661