Mdm2

MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) …

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer …

WAY-300374 inhibits the p53-MDM2 protein-protein interaction.

RDR03871 is an MDM2 inhibitor.

Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it …

MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor …

Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki …

RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, …

VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it …

SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).

Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.

Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and …

RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.

Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with …

MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.

NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds …

AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 …

Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which …

RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. …

Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of …

Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).

RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of …

NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).

Tenovin-6 is a p53 transcriptional activity agonist.

SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.

PhiKan 083 is a carbazole derivative

UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 …

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and …

Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).

MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy …

Milademetan is a specific and oral inhibitor of MDM2.

AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).