PERK
Los inhibidores de PERK (quinasa del retículo endoplásmico similar a la proteína quinasa R (PKR)) se dirigen a la vía PERK, que está involucrada en la respuesta celular al estrés del retículo endoplásmico (ER) y en la regulación de la apoptosis. PERK juega un papel crucial en la respuesta a proteínas mal plegadas (UPR) al detener la traducción de proteínas y promover la supervivencia celular bajo condiciones de estrés. Sin embargo, la activación prolongada de PERK puede conducir a la apoptosis. Inhibir PERK puede modular estas respuestas al estrés, lo que convierte a estos inhibidores en herramientas valiosas en la investigación de enfermedades neurodegenerativas, cáncer y trastornos metabólicos. En CymitQuimica, ofrecemos una gama de inhibidores de PERK de alta calidad para apoyar su investigación en apoptosis, estrés del RE y homeostasis celular.
Se han encontrado 23 productos de "PERK"
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.96%Forma y color:SolidPeso molecular:811.05PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Fórmula:C23H22N6OPureza:99.62% - 99.92%Forma y color:SolidPeso molecular:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Forma y color:SolidPeso molecular:469.43Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Forma y color:SolidPeso molecular:490.31EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Fórmula:C21H20F6N2O2Pureza:98.86%Forma y color:SolidPeso molecular:446.39Ref: TM-T62637
1mg58,00€5mg124,00€1mL*10mM (DMSO)136,00€10mg192,00€25mg360,00€50mg527,00€100mg757,00€200mg1.036,00€2BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFórmula:C19H16ClF3N4O3Pureza:97.97% - 99.04%Forma y color:SolidPeso molecular:440.8Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Fórmula:C26H36O6Pureza:99.45% - 99.91%Forma y color:White To Off-White SolidPeso molecular:444.56Ref: TM-T5A2461
1mg46,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg137,00€25mg224,00€50mg331,00€100mg489,00€500mg1.044,00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Fórmula:C25H28N2O5S2Pureza:97.82%Forma y color:SolidPeso molecular:500.63GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Forma y color:SolidPeso molecular:489.91IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.27GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Fórmula:C24H20F3N5OPureza:98% - >99.99%Forma y color:SolidPeso molecular:451.44Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Forma y color:SolidPeso molecular:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€1mL*10mM (DMSO)243,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Forma y color:SolidPeso molecular:451.34GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Forma y color:SolidPeso molecular:416.45Ref: TM-T2654
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg135,00€50mg245,00€100mg442,00€200mg598,00€DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Fórmula:C20H19ClF3N3O4Pureza:99.96%Forma y color:SolidPeso molecular:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.
Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Forma y color:SolidPeso molecular:588.88GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98%Forma y color:SolidPeso molecular:485.29HR-19011
CAS:HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Fórmula:C25H19F6N3O3Pureza:99.89%Forma y color:SolidPeso molecular:523.43Ref: TM-T63665
2mg85,00€5mg130,00€1mL*10mM (DMSO)150,00€10mg207,00€25mg418,00€50mg666,00€100mg1.046,00€200mg1.420,00€eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Fórmula:C31H33N3O5Forma y color:SolidPeso molecular:527.61HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Fórmula:C20H15ClF2N6O4SPureza:99.84%Forma y color:SolidPeso molecular:508.89HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Fórmula:C28H28F2N4O7Forma y color:SolidPeso molecular:570.54eIF4E-IN-4
CAS:eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.Fórmula:C20H19ClN5O5PForma y color:SolidPeso molecular:475.822HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Fórmula:C24H24F2N4O3Pureza:99.33%Forma y color:SolidPeso molecular:454.47
