
p53
Los inhibidores de p53 se dirigen a la proteína p53, un supresor tumoral que desempeña un papel crucial en la regulación del ciclo celular, la reparación del ADN y la apoptosis. Aunque p53 a menudo está mutado o inactivado en células cancerosas, su inhibición a veces es necesaria para proteger a las células sanas de la apoptosis durante ciertos tratamientos. Por otro lado, restaurar la función de p53 en los tumores puede conducir a la apoptosis de las células cancerosas. La investigación sobre inhibidores de p53 es compleja y significativa tanto para comprender los mecanismos del cáncer como para desarrollar nuevas terapias. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de p53 de alta calidad para apoyar su investigación en biología del cáncer, apoptosis y desarrollo terapéutico.
Se han encontrado 63 productos para "p53".
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Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Fórmula:C33H48O6Pureza:97.10% - 99.04%Forma y color:SolidPeso molecular:540.73Ref: TM-T15735
1mg192,00€1mL*10mM (DMSO)268,00€2mg324,00€5mg587,00€10mg835,00€25mg1.251,00€50mg1.684,00€100mg2.277,00€BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02Ref: TM-T1959
2mg50,00€5mg67,00€10mg102,00€1mL*10mM (DMSO)105,00€25mg182,00€50mg259,00€100mg447,00€200mg607,00€Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.70Ref: TM-T5429
1mg87,00€5mg169,00€10mg268,00€1mL*10mM (DMSO)268,00€25mg462,00€50mg647,00€100mg873,00€200mg1.153,00€Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H30Cl2N4O4Pureza:95.62% - 99.71%Forma y color:SolidPeso molecular:581.49Ref: TM-T6023
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)128,00€10mg156,00€25mg254,00€50mg376,00€100mg557,00€YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFórmula:C19H21BO7Pureza:99.47%Forma y color:SolidPeso molecular:372.18NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Fórmula:C23H20N2OPureza:96.94%Forma y color:Orange SolidPeso molecular:340.42O6-Benzylguanine
CAS:O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.Fórmula:C12H11N5OPureza:98.90%Forma y color:SolidPeso molecular:241.25UNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Fórmula:C26H43N7O2Pureza:99.80%Forma y color:Yellow SolidPeso molecular:485.67NSC 146109 hydrochloride
CAS:NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.Fórmula:C17H17ClN2SPureza:99.28%Forma y color:SolidPeso molecular:316.85UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Fórmula:C27H45N7O3Pureza:99.80%Forma y color:White SolidPeso molecular:515.69BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Fórmula:C14H16N2OSPureza:99.84%Forma y color:SolidPeso molecular:260.35Ref: TM-T36964
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg160,00€50mg264,00€100mg462,00€500mg982,00€PDK4-IN-1 hydrochloride
CAS:PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).Fórmula:C22H20ClN3O2Pureza:99.67%Forma y color:SolidPeso molecular:393.87Ref: TM-T12412L
1mg70,00€5mg150,00€1mL*10mM (DMSO)165,00€10mg215,00€25mg358,00€50mg515,00€100mg707,00€200mg1.009,00€
