Caspasa
Los inhibidores de caspasas son compuestos que bloquean la actividad de las caspasas, una familia de proteasas que son ejecutores centrales de la apoptosis. Las caspasas escinden sustratos específicos dentro de la célula para desencadenar el proceso apoptótico, lo que conduce a la muerte celular programada. Los inhibidores de caspasas se utilizan para estudiar los mecanismos de la apoptosis, así como para prevenir la muerte celular no deseada en varios modelos de investigación. Estos inhibidores también se exploran en contextos terapéuticos para proteger las células de la apoptosis en enfermedades como la neurodegeneración. En CymitQuimica, ofrecemos una amplia gama de inhibidores de caspasas de alta calidad para apoyar su investigación en apoptosis, muerte celular y campos relacionados.
Se han encontrado 125 productos de "Caspasa"
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p-nitro-Pifithrin-α
CAS:<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Fórmula:C15H16BrN3O3SForma y color:SolidPeso molecular:398.27SDZ 224-015
CAS:<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Fórmula:C30H35Cl2N3O9Pureza:95.49% - 95.49%Forma y color:SolidPeso molecular:652.52VRT-043198
CAS:<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Fórmula:C22H29ClN4O6Forma y color:SolidPeso molecular:480.94QM31
CAS:<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Fórmula:C39H38Cl4N4O4Pureza:98%Forma y color:SolidPeso molecular:768.56N1,N11-Diethylnorspermine
CAS:<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Fórmula:C13H32N4Forma y color:SolidPeso molecular:244.42GRI977143
CAS:<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Fórmula:C22H17NO4SPureza:98.07%Forma y color:SolidPeso molecular:391.44OT-82
CAS:<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Fórmula:C26H21FN4OPureza:98.91% - 99.315%Forma y color:SolidPeso molecular:424.47ML132
CAS:<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Fórmula:C22H28ClN5O5Forma y color:SolidPeso molecular:477.94CZL55
CAS:<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Fórmula:C20H22N2O6Pureza:98.19%Forma y color:SolidPeso molecular:386.4NLRP3 agonist 1
CAS:<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Fórmula:C15H16N6Pureza:99.01%Forma y color:SolidPeso molecular:280.33M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Fórmula:C21H21N5O2Pureza:98%Forma y color:SolidPeso molecular:375.42Ac-YVAD-pNA
CAS:<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Fórmula:C29H36N6O10Forma y color:SolidPeso molecular:628.639GDC-2394
CAS:<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Fórmula:C20H25N5O4SForma y color:SolidPeso molecular:431.51CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Fórmula:C23H26O5Pureza:97.07%Forma y color:SolidPeso molecular:382.45EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Fórmula:C18H23FN2O6Pureza:98%Forma y color:SolidPeso molecular:382.38M867
CAS:<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Fórmula:C27H43N7O6Pureza:98%Forma y color:SolidPeso molecular:561.67Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Fórmula:C14H23N3O6Pureza:98%Forma y color:SolidPeso molecular:329.35Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Fórmula:C30H37ClN4O9Pureza:98%Forma y color:SolidPeso molecular:633.09ZIF-8
CAS:<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Fórmula:C4H6N2ZnForma y color:SolidPeso molecular:147.513Caspase-3-IN-2
CAS:<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Fórmula:C10H6ClNO5Forma y color:SolidPeso molecular:255.611
