Caspasa
Los inhibidores de caspasas son compuestos que bloquean la actividad de las caspasas, una familia de proteasas que son ejecutores centrales de la apoptosis. Las caspasas escinden sustratos específicos dentro de la célula para desencadenar el proceso apoptótico, lo que conduce a la muerte celular programada. Los inhibidores de caspasas se utilizan para estudiar los mecanismos de la apoptosis, así como para prevenir la muerte celular no deseada en varios modelos de investigación. Estos inhibidores también se exploran en contextos terapéuticos para proteger las células de la apoptosis en enfermedades como la neurodegeneración. En CymitQuimica, ofrecemos una amplia gama de inhibidores de caspasas de alta calidad para apoyar su investigación en apoptosis, muerte celular y campos relacionados.
Se han encontrado 144 productos de "Caspasa"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ac-DEVD-CHO acetate
Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.Fórmula:C22H34N4O13Pureza:98.54%Forma y color:SolidPeso molecular:562.52BC-1471
CAS:BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.Fórmula:C27H32N4O4SPureza:99.98%Forma y color:SolidPeso molecular:508.63Dehydrocorydaline nitrate
CAS:DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Forma y color:SolidPeso molecular:428.44Dehydrotrametenolic acid
CAS:Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation inFórmula:C31H48O3Pureza:98%Forma y color:SolidPeso molecular:468.71Limonin glucoside
CAS:Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.Fórmula:C32H42O14Forma y color:SolidPeso molecular:650.674VRT-043198
CAS:VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.Fórmula:C22H29ClN4O6Forma y color:SolidPeso molecular:480.94Tigilanol tiglate
CAS:Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.Fórmula:C30H42O10Pureza:98%Forma y color:SolidPeso molecular:562.65QM31
CAS:QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).Fórmula:C39H38Cl4N4O4Pureza:98%Forma y color:SolidPeso molecular:768.56N1,N11-Diethylnorspermine
CAS:DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.Fórmula:C13H32N4Forma y color:SolidPeso molecular:244.42ZYZ-488
CAS:ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.Fórmula:C20H29N3O11Pureza:99.04%Forma y color:SolidPeso molecular:487.46SDZ 224-015
CAS:SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.Fórmula:C30H35Cl2N3O9Pureza:95.49% - 95.49%Forma y color:SolidPeso molecular:652.52GRI977143
CAS:GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.Fórmula:C22H17NO4SPureza:99.08%Forma y color:SolidPeso molecular:391.44p-nitro-Pifithrin-α
CAS:p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.Fórmula:C15H16BrN3O3SForma y color:SolidPeso molecular:398.27Caspase-9 Inhibitor III
CAS:Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.Fórmula:C24H35ClN6O9Forma y color:SolidPeso molecular:587.02OT-82
CAS:OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.Fórmula:C26H21FN4OPureza:98.91% - 99.315%Forma y color:SolidPeso molecular:424.47Anisperimus
CAS:<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Fórmula:C18H39N7O3Pureza:98.10%Forma y color:SolidPeso molecular:401.55S1QEL1.1
CAS:S1QEL1.1 (S1QEL) is an electron leakage inhibitor that inhibits O2-induced ROS generation and prevents O2-induced DA closure.Fórmula:C23H24N4O3SPureza:99.93%Forma y color:SolidPeso molecular:436.53ML132
CAS:ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).Fórmula:C22H28ClN5O5Forma y color:SolidPeso molecular:477.94Caspase-3-IN-1
CAS:Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).Fórmula:C26H25N3O6SForma y color:SolidPeso molecular:507.562-chloro Palmitic Acid
CAS:2-chloro Palmitic acid triggers NETosis, elevates COX-2, adhesion molecules in HCAECs, and induces apoptosis and caspase-3 in THP-1 cells/monocytes.Fórmula:C16H31ClO2Forma y color:SolidPeso molecular:290.87CAY10406
CAS:CAY10406, a trifluoromethyl isatin sulfonamide, selectively targets and inhibits caspase-3 and -7, key in apoptosis, with no data on its inhibition potency.Fórmula:C27H23F3N2O5SForma y color:SolidPeso molecular:544.54AD-2646
CAS:AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.Fórmula:C23H40N2O4Forma y color:SolidPeso molecular:408.57CZL55
CAS:CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).Fórmula:C20H22N2O6Pureza:98.19%Forma y color:SolidPeso molecular:386.4GDC-2394
CAS:GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.Fórmula:C20H25N5O4SForma y color:SolidPeso molecular:431.51Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Fórmula:C14H23N3O6Pureza:98%Forma y color:SolidPeso molecular:329.35Ac-YVAD-pNA
CAS:Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].Fórmula:C29H36N6O10Forma y color:SolidPeso molecular:628.639Z-YVAD-CMK
CAS:Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].Fórmula:C30H37ClN4O9Pureza:98%Forma y color:SolidPeso molecular:633.09M190S
CAS:M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.Fórmula:C21H21N5O2Pureza:98%Forma y color:SolidPeso molecular:375.42CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Fórmula:C23H26O5Pureza:97.07%Forma y color:SolidPeso molecular:382.45NLRP3 agonist 1
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Fórmula:C15H16N6Pureza:99.01%Forma y color:SolidPeso molecular:280.33EP1013
CAS:EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.Fórmula:C18H23FN2O6Pureza:98%Forma y color:SolidPeso molecular:382.38M867
CAS:M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Fórmula:C27H43N7O6Pureza:98%Forma y color:SolidPeso molecular:561.67N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS:N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.Fórmula:C14H22Cl2N2O3SPeso molecular:369.31NLRP3-IN-81
CAS:NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.Fórmula:C16H15F3N2O3SForma y color:SolidPeso molecular:372.36Z-VA-DL-D-FMK
CAS:Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Fórmula:C21H28FN3O7Forma y color:SolidPeso molecular:453.46Neuroprotective agent 11
CAS:Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Fórmula:C32H30O12Forma y color:SolidPeso molecular:606.57M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7DeFer-2
CAS:DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Fórmula:C44H69N5O5SForma y color:SolidPeso molecular:780.11Z-VAD-AMC
CAS:Z-VAD-AMC acts as a substrate specifically for caspase-9.Fórmula:C30H34N4O9Peso molecular:594.61Ac-DMLD-CMK
CAS:Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.Fórmula:C22H35ClN4O9SForma y color:SolidPeso molecular:567.053Caspase-3-IN-2
CAS:Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Fórmula:C10H6ClNO5Forma y color:SolidPeso molecular:255.611ZIF-8
CAS:ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.Fórmula:C4H6N2ZnForma y color:SolidPeso molecular:147.513Ac-Asp-Glu-Val-Asp-pNA
CAS:Ac-Asp-Glu-Val-Asp-pNA is a peptide substrate for caspase-3/7.Fórmula:C26H34N6O13Peso molecular:638.58GlcNAc-MurNAc
CAS:GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.Fórmula:C19H32N2O13Forma y color:SolidPeso molecular:496.46
